| Full name: dickkopf WNT signaling pathway inhibitor 3 | Alias Symbol: REIC|RIG | ||
| Type: protein-coding gene | Cytoband: 11p15.3 | ||
| Entrez ID: 27122 | HGNC ID: HGNC:2893 | Ensembl Gene: ENSG00000050165 | OMIM ID: 605416 |
| Drug and gene relationship at DGIdb | |||
Expression of DKK3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DKK3 | 27122 | 214247_s_at | 0.0239 | 0.9857 | |
| GSE20347 | DKK3 | 27122 | 214247_s_at | 0.3490 | 0.2466 | |
| GSE23400 | DKK3 | 27122 | 214247_s_at | 0.5550 | 0.0002 | |
| GSE26886 | DKK3 | 27122 | 214247_s_at | 2.0125 | 0.0000 | |
| GSE29001 | DKK3 | 27122 | 214247_s_at | 0.3363 | 0.4304 | |
| GSE38129 | DKK3 | 27122 | 214247_s_at | 0.2364 | 0.4331 | |
| GSE45670 | DKK3 | 27122 | 214247_s_at | 0.0265 | 0.9585 | |
| GSE53622 | DKK3 | 27122 | 7826 | 0.8810 | 0.0000 | |
| GSE53624 | DKK3 | 27122 | 7826 | 0.9173 | 0.0000 | |
| GSE63941 | DKK3 | 27122 | 214247_s_at | -4.5013 | 0.0330 | |
| GSE77861 | DKK3 | 27122 | 214247_s_at | 0.4741 | 0.3566 | |
| GSE97050 | DKK3 | 27122 | A_24_P261417 | 0.2213 | 0.6565 | |
| SRP007169 | DKK3 | 27122 | RNAseq | 1.3906 | 0.0001 | |
| SRP008496 | DKK3 | 27122 | RNAseq | 1.8584 | 0.0000 | |
| SRP064894 | DKK3 | 27122 | RNAseq | 0.6254 | 0.0004 | |
| SRP133303 | DKK3 | 27122 | RNAseq | 1.1710 | 0.0007 | |
| SRP159526 | DKK3 | 27122 | RNAseq | 0.5582 | 0.1047 | |
| SRP193095 | DKK3 | 27122 | RNAseq | 1.3466 | 0.0000 | |
| SRP219564 | DKK3 | 27122 | RNAseq | 0.7988 | 0.2150 | |
| TCGA | DKK3 | 27122 | RNAseq | 0.1577 | 0.0951 |
Upregulated datasets: 5; Downregulated datasets: 1.
Survival by DKK3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DKK3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DKK3 | 27122 | 0 | 9 | 21 | |
| GSE20123 | DKK3 | 27122 | 0 | 9 | 21 | |
| GSE43470 | DKK3 | 27122 | 1 | 5 | 37 | |
| GSE46452 | DKK3 | 27122 | 7 | 5 | 47 | |
| GSE47630 | DKK3 | 27122 | 3 | 11 | 26 | |
| GSE54993 | DKK3 | 27122 | 3 | 1 | 66 | |
| GSE54994 | DKK3 | 27122 | 4 | 12 | 37 | |
| GSE60625 | DKK3 | 27122 | 0 | 0 | 11 | |
| GSE74703 | DKK3 | 27122 | 1 | 3 | 32 | |
| GSE74704 | DKK3 | 27122 | 0 | 7 | 13 | |
| TCGA | DKK3 | 27122 | 11 | 33 | 52 |
Total number of gains: 30; Total number of losses: 95; Total Number of normals: 363.
Somatic mutations of DKK3:
Generating mutation plots.
Highly correlated genes for DKK3:
Showing top 20/601 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DKK3 | ANTXR1 | 0.716111 | 9 | 0 | 8 |
| DKK3 | CBX2 | 0.714736 | 3 | 0 | 3 |
| DKK3 | COL12A1 | 0.709259 | 9 | 0 | 9 |
| DKK3 | KREMEN2 | 0.681877 | 3 | 0 | 3 |
| DKK3 | B3GNT9 | 0.660383 | 7 | 0 | 7 |
| DKK3 | HTRA1 | 0.659558 | 13 | 0 | 10 |
| DKK3 | CDH11 | 0.656178 | 12 | 0 | 11 |
| DKK3 | GPX8 | 0.654385 | 8 | 0 | 7 |
| DKK3 | LGALS1 | 0.648074 | 12 | 0 | 10 |
| DKK3 | SLC39A13 | 0.646631 | 7 | 0 | 6 |
| DKK3 | FSTL1 | 0.64544 | 12 | 0 | 10 |
| DKK3 | COL8A1 | 0.644764 | 11 | 0 | 9 |
| DKK3 | COL6A1 | 0.644133 | 13 | 0 | 11 |
| DKK3 | FNDC1 | 0.641676 | 8 | 0 | 6 |
| DKK3 | E2F6 | 0.639729 | 3 | 0 | 3 |
| DKK3 | GALNT18 | 0.639246 | 6 | 0 | 5 |
| DKK3 | GAS1 | 0.638705 | 11 | 0 | 10 |
| DKK3 | LAMC1 | 0.638611 | 13 | 0 | 11 |
| DKK3 | RPN2 | 0.638607 | 4 | 0 | 4 |
| DKK3 | IGFBP7 | 0.638497 | 12 | 0 | 10 |
For details and further investigation, click here
