| Full name: NLR family pyrin domain containing 1 | Alias Symbol: KIAA0926|DKFZp586O1822|CARD7|NAC|CLR17.1|DEFCAP|VAMAS1 | ||
| Type: protein-coding gene | Cytoband: 17p13 | ||
| Entrez ID: 22861 | HGNC ID: HGNC:14374 | Ensembl Gene: ENSG00000091592 | OMIM ID: 606636 |
| Drug and gene relationship at DGIdb | |||
NLRP1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04621 | NOD-like receptor signaling pathway |
Expression of NLRP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NLRP1 | 22861 | 210113_s_at | -0.1131 | 0.8888 | |
| GSE20347 | NLRP1 | 22861 | 210113_s_at | 0.1932 | 0.4137 | |
| GSE23400 | NLRP1 | 22861 | 210113_s_at | 0.1648 | 0.0858 | |
| GSE26886 | NLRP1 | 22861 | 210113_s_at | 0.3535 | 0.0374 | |
| GSE29001 | NLRP1 | 22861 | 210113_s_at | -0.1566 | 0.5948 | |
| GSE38129 | NLRP1 | 22861 | 210113_s_at | -0.0358 | 0.8670 | |
| GSE45670 | NLRP1 | 22861 | 210113_s_at | 0.1025 | 0.7249 | |
| GSE53622 | NLRP1 | 22861 | 87357 | 0.3085 | 0.0220 | |
| GSE53624 | NLRP1 | 22861 | 3259 | 0.1549 | 0.0984 | |
| GSE63941 | NLRP1 | 22861 | 210113_s_at | -0.8129 | 0.1567 | |
| GSE77861 | NLRP1 | 22861 | 1562256_at | 0.0542 | 0.8215 | |
| GSE97050 | NLRP1 | 22861 | A_24_P83615 | 0.5770 | 0.2584 | |
| SRP007169 | NLRP1 | 22861 | RNAseq | 0.1132 | 0.8459 | |
| SRP008496 | NLRP1 | 22861 | RNAseq | 0.1754 | 0.6754 | |
| SRP064894 | NLRP1 | 22861 | RNAseq | 0.1482 | 0.6547 | |
| SRP133303 | NLRP1 | 22861 | RNAseq | -0.2426 | 0.3303 | |
| SRP159526 | NLRP1 | 22861 | RNAseq | 0.1715 | 0.7265 | |
| SRP193095 | NLRP1 | 22861 | RNAseq | 0.6374 | 0.0056 | |
| SRP219564 | NLRP1 | 22861 | RNAseq | -0.2356 | 0.6739 | |
| TCGA | NLRP1 | 22861 | RNAseq | 0.2750 | 0.0226 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by NLRP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NLRP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NLRP1 | 22861 | 5 | 2 | 23 | |
| GSE20123 | NLRP1 | 22861 | 5 | 3 | 22 | |
| GSE43470 | NLRP1 | 22861 | 1 | 6 | 36 | |
| GSE46452 | NLRP1 | 22861 | 34 | 1 | 24 | |
| GSE47630 | NLRP1 | 22861 | 7 | 1 | 32 | |
| GSE54993 | NLRP1 | 22861 | 4 | 3 | 63 | |
| GSE54994 | NLRP1 | 22861 | 5 | 8 | 40 | |
| GSE60625 | NLRP1 | 22861 | 4 | 0 | 7 | |
| GSE74703 | NLRP1 | 22861 | 1 | 3 | 32 | |
| GSE74704 | NLRP1 | 22861 | 3 | 1 | 16 | |
| TCGA | NLRP1 | 22861 | 18 | 20 | 58 |
Total number of gains: 87; Total number of losses: 48; Total Number of normals: 353.
Somatic mutations of NLRP1:
Generating mutation plots.
Highly correlated genes for NLRP1:
Showing top 20/96 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NLRP1 | DLL1 | 0.738206 | 3 | 0 | 3 |
| NLRP1 | GXYLT2 | 0.687974 | 4 | 0 | 4 |
| NLRP1 | SUPT7L | 0.681895 | 3 | 0 | 3 |
| NLRP1 | CD44 | 0.681849 | 4 | 0 | 3 |
| NLRP1 | CD82 | 0.670405 | 4 | 0 | 3 |
| NLRP1 | KPNA5 | 0.666882 | 3 | 0 | 3 |
| NLRP1 | MB21D2 | 0.661739 | 3 | 0 | 3 |
| NLRP1 | FLT1 | 0.651056 | 3 | 0 | 3 |
| NLRP1 | C8orf37 | 0.647086 | 3 | 0 | 3 |
| NLRP1 | GOPC | 0.641712 | 5 | 0 | 3 |
| NLRP1 | ATP6V1E2 | 0.641139 | 3 | 0 | 3 |
| NLRP1 | AJUBA | 0.639244 | 4 | 0 | 3 |
| NLRP1 | SREK1IP1 | 0.635529 | 3 | 0 | 3 |
| NLRP1 | UBTD2 | 0.634671 | 3 | 0 | 3 |
| NLRP1 | CD109 | 0.629091 | 3 | 0 | 3 |
| NLRP1 | TBP | 0.627549 | 3 | 0 | 3 |
| NLRP1 | FEZ1 | 0.625388 | 4 | 0 | 3 |
| NLRP1 | PTPN12 | 0.624197 | 4 | 0 | 3 |
| NLRP1 | CEBPD | 0.622742 | 3 | 0 | 3 |
| NLRP1 | CHST11 | 0.621033 | 5 | 0 | 3 |
For details and further investigation, click here
