| Full name: delta like canonical Notch ligand 3 | Alias Symbol: SCDO1 | ||
| Type: protein-coding gene | Cytoband: 19q13.2 | ||
| Entrez ID: 10683 | HGNC ID: HGNC:2909 | Ensembl Gene: ENSG00000090932 | OMIM ID: 602768 |
| Drug and gene relationship at DGIdb | |||
DLL3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04330 | Notch signaling pathway |
Expression of DLL3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DLL3 | 10683 | 229755_x_at | 0.0434 | 0.8687 | |
| GSE20347 | DLL3 | 10683 | 219537_x_at | 0.0670 | 0.5665 | |
| GSE23400 | DLL3 | 10683 | 219537_x_at | -0.0161 | 0.6930 | |
| GSE26886 | DLL3 | 10683 | 230568_x_at | 0.1958 | 0.1330 | |
| GSE29001 | DLL3 | 10683 | 219537_x_at | 0.1580 | 0.3555 | |
| GSE38129 | DLL3 | 10683 | 219537_x_at | 0.3290 | 0.0699 | |
| GSE45670 | DLL3 | 10683 | 222898_s_at | 0.0354 | 0.7408 | |
| GSE63941 | DLL3 | 10683 | 219537_x_at | 0.2466 | 0.5397 | |
| GSE77861 | DLL3 | 10683 | 230568_x_at | -0.0387 | 0.7210 | |
| GSE97050 | DLL3 | 10683 | A_24_P57047 | 0.2747 | 0.2204 | |
| TCGA | DLL3 | 10683 | RNAseq | 3.5674 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by DLL3 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of DLL3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DLL3 | 10683 | 7 | 4 | 19 | |
| GSE20123 | DLL3 | 10683 | 7 | 3 | 20 | |
| GSE43470 | DLL3 | 10683 | 3 | 11 | 29 | |
| GSE46452 | DLL3 | 10683 | 48 | 1 | 10 | |
| GSE47630 | DLL3 | 10683 | 9 | 5 | 26 | |
| GSE54993 | DLL3 | 10683 | 17 | 3 | 50 | |
| GSE54994 | DLL3 | 10683 | 7 | 9 | 37 | |
| GSE60625 | DLL3 | 10683 | 9 | 0 | 2 | |
| GSE74703 | DLL3 | 10683 | 3 | 7 | 26 | |
| GSE74704 | DLL3 | 10683 | 7 | 1 | 12 | |
| TCGA | DLL3 | 10683 | 14 | 16 | 66 |
Total number of gains: 131; Total number of losses: 60; Total Number of normals: 297.
Somatic mutations of DLL3:
Generating mutation plots.
Highly correlated genes for DLL3:
Showing top 20/95 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DLL3 | CAGE1 | 0.67555 | 4 | 0 | 3 |
| DLL3 | TMEM214 | 0.663347 | 3 | 0 | 3 |
| DLL3 | SLC6A12 | 0.63102 | 3 | 0 | 3 |
| DLL3 | AMZ1 | 0.61664 | 3 | 0 | 3 |
| DLL3 | ADAMTSL2 | 0.60911 | 4 | 0 | 3 |
| DLL3 | EFCAB13 | 0.595404 | 4 | 0 | 4 |
| DLL3 | FRMD5 | 0.59536 | 4 | 0 | 3 |
| DLL3 | HOXC8 | 0.593448 | 6 | 0 | 5 |
| DLL3 | C2CD4C | 0.592325 | 3 | 0 | 3 |
| DLL3 | C3orf33 | 0.591688 | 3 | 0 | 3 |
| DLL3 | DOC2A | 0.591562 | 4 | 0 | 4 |
| DLL3 | STRADA | 0.591151 | 3 | 0 | 3 |
| DLL3 | CD180 | 0.590816 | 4 | 0 | 3 |
| DLL3 | CCNA1 | 0.590726 | 3 | 0 | 3 |
| DLL3 | SYP | 0.5896 | 3 | 0 | 3 |
| DLL3 | BIN1 | 0.589123 | 4 | 0 | 3 |
| DLL3 | A4GALT | 0.586673 | 4 | 0 | 4 |
| DLL3 | SLC10A2 | 0.585084 | 3 | 0 | 3 |
| DLL3 | LAMC3 | 0.578283 | 4 | 0 | 4 |
| DLL3 | LINC00965 | 0.577497 | 3 | 0 | 3 |
For details and further investigation, click here
