| Full name: cyclin A1 | Alias Symbol: CT146 | ||
| Type: protein-coding gene | Cytoband: 13q13.3 | ||
| Entrez ID: 8900 | HGNC ID: HGNC:1577 | Ensembl Gene: ENSG00000133101 | OMIM ID: 604036 |
| Drug and gene relationship at DGIdb | |||
CCNA1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04110 | Cell cycle | |
| hsa04152 | AMPK signaling pathway | |
| hsa05169 | Epstein-Barr virus infection | |
| hsa05200 | Pathways in cancer | |
| hsa05221 | Acute myeloid leukemia |
Expression of CCNA1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CCNA1 | 8900 | 205899_at | 1.0795 | 0.4763 | |
| GSE20347 | CCNA1 | 8900 | 205899_at | 1.5174 | 0.0073 | |
| GSE23400 | CCNA1 | 8900 | 205899_at | 0.3345 | 0.0149 | |
| GSE26886 | CCNA1 | 8900 | 205899_at | 1.9935 | 0.0001 | |
| GSE29001 | CCNA1 | 8900 | 205899_at | 0.7420 | 0.0937 | |
| GSE38129 | CCNA1 | 8900 | 205899_at | 1.8132 | 0.0001 | |
| GSE45670 | CCNA1 | 8900 | 205899_at | 1.2890 | 0.0710 | |
| GSE53622 | CCNA1 | 8900 | 129720 | 3.4061 | 0.0000 | |
| GSE53624 | CCNA1 | 8900 | 129720 | 4.1611 | 0.0000 | |
| GSE63941 | CCNA1 | 8900 | 205899_at | 2.1644 | 0.2817 | |
| GSE77861 | CCNA1 | 8900 | 205899_at | 1.2388 | 0.1147 | |
| GSE97050 | CCNA1 | 8900 | A_23_P48414 | 1.3226 | 0.2045 | |
| SRP007169 | CCNA1 | 8900 | RNAseq | 9.7796 | 0.0000 | |
| SRP159526 | CCNA1 | 8900 | RNAseq | 6.7540 | 0.0000 | |
| TCGA | CCNA1 | 8900 | RNAseq | 3.0785 | 0.0000 |
Upregulated datasets: 8; Downregulated datasets: 0.
Survival by CCNA1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CCNA1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CCNA1 | 8900 | 0 | 16 | 14 | |
| GSE20123 | CCNA1 | 8900 | 0 | 15 | 15 | |
| GSE43470 | CCNA1 | 8900 | 2 | 13 | 28 | |
| GSE46452 | CCNA1 | 8900 | 0 | 33 | 26 | |
| GSE47630 | CCNA1 | 8900 | 2 | 27 | 11 | |
| GSE54993 | CCNA1 | 8900 | 12 | 2 | 56 | |
| GSE54994 | CCNA1 | 8900 | 1 | 17 | 35 | |
| GSE60625 | CCNA1 | 8900 | 0 | 3 | 8 | |
| GSE74703 | CCNA1 | 8900 | 2 | 10 | 24 | |
| GSE74704 | CCNA1 | 8900 | 0 | 12 | 8 | |
| TCGA | CCNA1 | 8900 | 7 | 40 | 49 |
Total number of gains: 26; Total number of losses: 188; Total Number of normals: 274.
Somatic mutations of CCNA1:
Generating mutation plots.
Highly correlated genes for CCNA1:
Showing top 20/1234 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CCNA1 | PLEKHG3 | 0.728138 | 3 | 0 | 3 |
| CCNA1 | WDR54 | 0.724314 | 7 | 0 | 7 |
| CCNA1 | RMI2 | 0.720083 | 3 | 0 | 3 |
| CCNA1 | DOCK11 | 0.712876 | 3 | 0 | 3 |
| CCNA1 | FABP4 | 0.70845 | 3 | 0 | 3 |
| CCNA1 | KCNE4 | 0.707912 | 3 | 0 | 3 |
| CCNA1 | CPT1C | 0.699972 | 4 | 0 | 4 |
| CCNA1 | CDSN | 0.698664 | 5 | 0 | 5 |
| CCNA1 | STEAP1B | 0.691573 | 6 | 0 | 6 |
| CCNA1 | ZNF114 | 0.6865 | 3 | 0 | 3 |
| CCNA1 | FITM2 | 0.684298 | 3 | 0 | 3 |
| CCNA1 | LINC00540 | 0.682516 | 3 | 0 | 3 |
| CCNA1 | VPS35 | 0.679182 | 3 | 0 | 3 |
| CCNA1 | INHBA | 0.677949 | 10 | 0 | 9 |
| CCNA1 | CRTC2 | 0.673159 | 3 | 0 | 3 |
| CCNA1 | PEAR1 | 0.672913 | 3 | 0 | 3 |
| CCNA1 | MAP1B | 0.672636 | 3 | 0 | 3 |
| CCNA1 | MSANTD3 | 0.672006 | 6 | 0 | 6 |
| CCNA1 | RCN3 | 0.667471 | 4 | 0 | 4 |
| CCNA1 | CLSTN2 | 0.667204 | 3 | 0 | 3 |
For details and further investigation, click here
