| Full name: bridging integrator 1 | Alias Symbol: SH3P9|AMPH2 | ||
| Type: protein-coding gene | Cytoband: 2q14.3 | ||
| Entrez ID: 274 | HGNC ID: HGNC:1052 | Ensembl Gene: ENSG00000136717 | OMIM ID: 601248 |
| Drug and gene relationship at DGIdb | |||
BIN1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04666 | Fc gamma R-mediated phagocytosis |
Expression of BIN1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BIN1 | 274 | 214439_x_at | 0.1974 | 0.7854 | |
| GSE20347 | BIN1 | 274 | 214439_x_at | 0.4450 | 0.0342 | |
| GSE23400 | BIN1 | 274 | 210201_x_at | -0.0813 | 0.4235 | |
| GSE26886 | BIN1 | 274 | 210201_x_at | 0.5507 | 0.1188 | |
| GSE29001 | BIN1 | 274 | 214439_x_at | 0.2486 | 0.3169 | |
| GSE38129 | BIN1 | 274 | 214439_x_at | -0.1107 | 0.7282 | |
| GSE45670 | BIN1 | 274 | 210201_x_at | -0.2689 | 0.2777 | |
| GSE53622 | BIN1 | 274 | 70373 | -0.1534 | 0.0737 | |
| GSE53624 | BIN1 | 274 | 70373 | -0.0100 | 0.9013 | |
| GSE63941 | BIN1 | 274 | 214439_x_at | -1.2045 | 0.0871 | |
| GSE77861 | BIN1 | 274 | 210202_s_at | 0.0686 | 0.7417 | |
| GSE97050 | BIN1 | 274 | A_23_P165333 | -0.2112 | 0.4329 | |
| SRP007169 | BIN1 | 274 | RNAseq | 0.5470 | 0.2271 | |
| SRP008496 | BIN1 | 274 | RNAseq | 0.5326 | 0.1918 | |
| SRP064894 | BIN1 | 274 | RNAseq | -0.1050 | 0.7642 | |
| SRP133303 | BIN1 | 274 | RNAseq | -0.3964 | 0.1301 | |
| SRP159526 | BIN1 | 274 | RNAseq | -0.0844 | 0.8402 | |
| SRP193095 | BIN1 | 274 | RNAseq | 0.8202 | 0.0090 | |
| SRP219564 | BIN1 | 274 | RNAseq | -0.2442 | 0.6379 | |
| TCGA | BIN1 | 274 | RNAseq | -0.3849 | 0.0003 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by BIN1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BIN1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BIN1 | 274 | 3 | 3 | 24 | |
| GSE20123 | BIN1 | 274 | 3 | 3 | 24 | |
| GSE43470 | BIN1 | 274 | 2 | 1 | 40 | |
| GSE46452 | BIN1 | 274 | 1 | 3 | 55 | |
| GSE47630 | BIN1 | 274 | 6 | 0 | 34 | |
| GSE54993 | BIN1 | 274 | 0 | 6 | 64 | |
| GSE54994 | BIN1 | 274 | 11 | 0 | 42 | |
| GSE60625 | BIN1 | 274 | 0 | 3 | 8 | |
| GSE74703 | BIN1 | 274 | 2 | 1 | 33 | |
| GSE74704 | BIN1 | 274 | 2 | 1 | 17 | |
| TCGA | BIN1 | 274 | 22 | 8 | 66 |
Total number of gains: 52; Total number of losses: 29; Total Number of normals: 407.
Somatic mutations of BIN1:
Generating mutation plots.
Highly correlated genes for BIN1:
Showing top 20/379 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BIN1 | TLN2 | 0.687918 | 3 | 0 | 3 |
| BIN1 | OAZ2 | 0.680832 | 3 | 0 | 3 |
| BIN1 | CDO1 | 0.666041 | 3 | 0 | 3 |
| BIN1 | PFKM | 0.664954 | 4 | 0 | 4 |
| BIN1 | C1RL | 0.659577 | 4 | 0 | 4 |
| BIN1 | PPP1R18 | 0.644666 | 4 | 0 | 4 |
| BIN1 | NLGN4X | 0.637514 | 4 | 0 | 3 |
| BIN1 | DYNLL2 | 0.633129 | 3 | 0 | 3 |
| BIN1 | FRZB | 0.632371 | 4 | 0 | 3 |
| BIN1 | EID3 | 0.629677 | 3 | 0 | 3 |
| BIN1 | FEZ1 | 0.628873 | 7 | 0 | 5 |
| BIN1 | DNAJC8 | 0.627875 | 4 | 0 | 3 |
| BIN1 | BCL9 | 0.622438 | 3 | 0 | 3 |
| BIN1 | SLC16A4 | 0.622417 | 5 | 0 | 3 |
| BIN1 | ARHGAP24 | 0.622234 | 3 | 0 | 3 |
| BIN1 | SH3GL2 | 0.622038 | 4 | 0 | 3 |
| BIN1 | FAM20C | 0.621077 | 3 | 0 | 3 |
| BIN1 | LIFR | 0.612845 | 4 | 0 | 3 |
| BIN1 | MAN1C1 | 0.612492 | 4 | 0 | 3 |
| BIN1 | SLC22A17 | 0.611949 | 5 | 0 | 3 |
For details and further investigation, click here
