| Full name: mitochondrial ribosomal protein L49 | Alias Symbol: NOF|NOF1|L49mt | ||
| Type: protein-coding gene | Cytoband: 11q13.1 | ||
| Entrez ID: 740 | HGNC ID: HGNC:1176 | Ensembl Gene: ENSG00000149792 | OMIM ID: 606866 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of MRPL49:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MRPL49 | 740 | 201717_at | 0.0155 | 0.9786 | |
| GSE20347 | MRPL49 | 740 | 201717_at | 0.0403 | 0.8017 | |
| GSE23400 | MRPL49 | 740 | 201717_at | 0.0623 | 0.2170 | |
| GSE26886 | MRPL49 | 740 | 201717_at | -0.0688 | 0.6673 | |
| GSE29001 | MRPL49 | 740 | 201717_at | 0.1574 | 0.3579 | |
| GSE38129 | MRPL49 | 740 | 201717_at | -0.0593 | 0.6447 | |
| GSE45670 | MRPL49 | 740 | 201717_at | 0.0891 | 0.5558 | |
| GSE53622 | MRPL49 | 740 | 91880 | 0.4339 | 0.0000 | |
| GSE53624 | MRPL49 | 740 | 91880 | 0.3611 | 0.0000 | |
| GSE63941 | MRPL49 | 740 | 201717_at | 1.2002 | 0.0197 | |
| GSE77861 | MRPL49 | 740 | 201717_at | -0.0182 | 0.9302 | |
| GSE97050 | MRPL49 | 740 | A_24_P201491 | 0.3379 | 0.2816 | |
| SRP007169 | MRPL49 | 740 | RNAseq | -0.5144 | 0.1456 | |
| SRP008496 | MRPL49 | 740 | RNAseq | -0.5333 | 0.0029 | |
| SRP064894 | MRPL49 | 740 | RNAseq | -0.2353 | 0.0752 | |
| SRP133303 | MRPL49 | 740 | RNAseq | 0.2243 | 0.3238 | |
| SRP159526 | MRPL49 | 740 | RNAseq | -0.2620 | 0.0706 | |
| SRP193095 | MRPL49 | 740 | RNAseq | -0.2315 | 0.0484 | |
| SRP219564 | MRPL49 | 740 | RNAseq | -0.4523 | 0.2499 | |
| TCGA | MRPL49 | 740 | RNAseq | 0.0201 | 0.6754 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by MRPL49 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MRPL49:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MRPL49 | 740 | 7 | 6 | 17 | |
| GSE20123 | MRPL49 | 740 | 7 | 6 | 17 | |
| GSE43470 | MRPL49 | 740 | 2 | 3 | 38 | |
| GSE46452 | MRPL49 | 740 | 11 | 3 | 45 | |
| GSE47630 | MRPL49 | 740 | 5 | 6 | 29 | |
| GSE54993 | MRPL49 | 740 | 3 | 0 | 67 | |
| GSE54994 | MRPL49 | 740 | 6 | 5 | 42 | |
| GSE60625 | MRPL49 | 740 | 0 | 3 | 8 | |
| GSE74703 | MRPL49 | 740 | 2 | 1 | 33 | |
| GSE74704 | MRPL49 | 740 | 5 | 4 | 11 | |
| TCGA | MRPL49 | 740 | 23 | 7 | 66 |
Total number of gains: 71; Total number of losses: 44; Total Number of normals: 373.
Somatic mutations of MRPL49:
Generating mutation plots.
Highly correlated genes for MRPL49:
Showing top 20/214 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MRPL49 | DOCK5 | 0.795484 | 3 | 0 | 3 |
| MRPL49 | SLC16A5 | 0.736463 | 3 | 0 | 3 |
| MRPL49 | BAG6 | 0.728118 | 3 | 0 | 3 |
| MRPL49 | TUFM | 0.71242 | 3 | 0 | 3 |
| MRPL49 | PNKD | 0.709681 | 3 | 0 | 3 |
| MRPL49 | LCMT2 | 0.697587 | 3 | 0 | 3 |
| MRPL49 | GHDC | 0.692495 | 3 | 0 | 3 |
| MRPL49 | RBM4 | 0.68411 | 3 | 0 | 3 |
| MRPL49 | ZNF174 | 0.683291 | 5 | 0 | 4 |
| MRPL49 | PKP2 | 0.682646 | 3 | 0 | 3 |
| MRPL49 | MTA2 | 0.680427 | 3 | 0 | 3 |
| MRPL49 | RNF26 | 0.678261 | 4 | 0 | 3 |
| MRPL49 | SDR39U1 | 0.673857 | 3 | 0 | 3 |
| MRPL49 | MRPL38 | 0.670799 | 3 | 0 | 3 |
| MRPL49 | TMEM138 | 0.670597 | 3 | 0 | 3 |
| MRPL49 | PPP1R8 | 0.668122 | 4 | 0 | 3 |
| MRPL49 | KLHL7 | 0.666239 | 4 | 0 | 3 |
| MRPL49 | TMEM60 | 0.664002 | 4 | 0 | 3 |
| MRPL49 | ZMAT5 | 0.66208 | 3 | 0 | 3 |
| MRPL49 | MKS1 | 0.661168 | 5 | 0 | 5 |
For details and further investigation, click here
