| Full name: docking protein 3 | Alias Symbol: FLJ22570 | ||
| Type: protein-coding gene | Cytoband: 5q35.3 | ||
| Entrez ID: 79930 | HGNC ID: HGNC:24583 | Ensembl Gene: ENSG00000146094 | OMIM ID: 611435 |
| Drug and gene relationship at DGIdb | |||
Expression of DOK3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DOK3 | 79930 | 220320_at | -0.1462 | 0.5655 | |
| GSE20347 | DOK3 | 79930 | 220320_at | -0.1480 | 0.0896 | |
| GSE23400 | DOK3 | 79930 | 220320_at | -0.2531 | 0.0000 | |
| GSE26886 | DOK3 | 79930 | 220320_at | -0.1463 | 0.3871 | |
| GSE29001 | DOK3 | 79930 | 220320_at | -0.2945 | 0.0715 | |
| GSE38129 | DOK3 | 79930 | 220320_at | -0.1755 | 0.0090 | |
| GSE45670 | DOK3 | 79930 | 220320_at | 0.0639 | 0.5264 | |
| GSE53622 | DOK3 | 79930 | 81657 | 0.3935 | 0.0012 | |
| GSE53624 | DOK3 | 79930 | 46842 | 0.3676 | 0.0145 | |
| GSE63941 | DOK3 | 79930 | 220320_at | 0.3483 | 0.0429 | |
| GSE77861 | DOK3 | 79930 | 220320_at | -0.1355 | 0.2084 | |
| GSE97050 | DOK3 | 79930 | A_33_P3228564 | 0.7129 | 0.1958 | |
| SRP064894 | DOK3 | 79930 | RNAseq | 1.3835 | 0.0000 | |
| SRP133303 | DOK3 | 79930 | RNAseq | 0.5928 | 0.0274 | |
| SRP159526 | DOK3 | 79930 | RNAseq | -0.1181 | 0.8415 | |
| SRP193095 | DOK3 | 79930 | RNAseq | 1.1063 | 0.0005 | |
| SRP219564 | DOK3 | 79930 | RNAseq | 0.9888 | 0.0252 | |
| TCGA | DOK3 | 79930 | RNAseq | 0.1948 | 0.1227 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by DOK3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DOK3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DOK3 | 79930 | 2 | 13 | 15 | |
| GSE20123 | DOK3 | 79930 | 2 | 13 | 15 | |
| GSE43470 | DOK3 | 79930 | 1 | 11 | 31 | |
| GSE46452 | DOK3 | 79930 | 0 | 27 | 32 | |
| GSE47630 | DOK3 | 79930 | 1 | 20 | 19 | |
| GSE54993 | DOK3 | 79930 | 10 | 2 | 58 | |
| GSE54994 | DOK3 | 79930 | 2 | 17 | 34 | |
| GSE60625 | DOK3 | 79930 | 1 | 0 | 10 | |
| GSE74703 | DOK3 | 79930 | 1 | 7 | 28 | |
| GSE74704 | DOK3 | 79930 | 1 | 6 | 13 | |
| TCGA | DOK3 | 79930 | 8 | 34 | 54 |
Total number of gains: 29; Total number of losses: 150; Total Number of normals: 309.
Somatic mutations of DOK3:
Generating mutation plots.
Highly correlated genes for DOK3:
Showing top 20/741 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DOK3 | CSF2RB | 0.773359 | 4 | 0 | 4 |
| DOK3 | CPA2 | 0.696364 | 3 | 0 | 3 |
| DOK3 | RBP4 | 0.679751 | 3 | 0 | 3 |
| DOK3 | ALOX5AP | 0.678127 | 4 | 0 | 4 |
| DOK3 | GP9 | 0.673826 | 8 | 0 | 7 |
| DOK3 | DRP2 | 0.667008 | 7 | 0 | 7 |
| DOK3 | NPY | 0.666939 | 3 | 0 | 3 |
| DOK3 | LEMD1-AS1 | 0.662938 | 4 | 0 | 4 |
| DOK3 | LRRC25 | 0.659064 | 4 | 0 | 3 |
| DOK3 | AIRE | 0.658987 | 5 | 0 | 4 |
| DOK3 | KIAA1614 | 0.658403 | 6 | 0 | 5 |
| DOK3 | CASQ1 | 0.657685 | 3 | 0 | 3 |
| DOK3 | SLC2A4 | 0.65759 | 4 | 0 | 4 |
| DOK3 | BFSP2 | 0.656246 | 7 | 0 | 6 |
| DOK3 | CHRD | 0.656095 | 4 | 0 | 4 |
| DOK3 | TSC22D4 | 0.655599 | 3 | 0 | 3 |
| DOK3 | SPI1 | 0.654978 | 4 | 0 | 3 |
| DOK3 | FMNL1 | 0.654077 | 4 | 0 | 3 |
| DOK3 | RHAG | 0.653569 | 3 | 0 | 3 |
| DOK3 | HCLS1 | 0.649116 | 3 | 0 | 3 |
For details and further investigation, click here
