| Full name: arachidonate 5-lipoxygenase activating protein | Alias Symbol: FLAP | ||
| Type: protein-coding gene | Cytoband: 13q12.3 | ||
| Entrez ID: 241 | HGNC ID: HGNC:436 | Ensembl Gene: ENSG00000132965 | OMIM ID: 603700 |
| Drug and gene relationship at DGIdb | |||
Expression of ALOX5AP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ALOX5AP | 241 | 204174_at | 0.4256 | 0.8411 | |
| GSE20347 | ALOX5AP | 241 | 204174_at | -0.3331 | 0.0261 | |
| GSE23400 | ALOX5AP | 241 | 204174_at | 0.1696 | 0.1054 | |
| GSE26886 | ALOX5AP | 241 | 204174_at | -0.4433 | 0.1238 | |
| GSE29001 | ALOX5AP | 241 | 204174_at | -0.1924 | 0.2063 | |
| GSE38129 | ALOX5AP | 241 | 204174_at | -0.1633 | 0.6159 | |
| GSE45670 | ALOX5AP | 241 | 204174_at | -0.4944 | 0.1260 | |
| GSE53622 | ALOX5AP | 241 | 76526 | 0.1857 | 0.1484 | |
| GSE53624 | ALOX5AP | 241 | 76526 | -0.1401 | 0.4548 | |
| GSE63941 | ALOX5AP | 241 | 204174_at | -0.0646 | 0.8674 | |
| GSE77861 | ALOX5AP | 241 | 204174_at | -0.5113 | 0.2182 | |
| GSE97050 | ALOX5AP | 241 | A_24_P347378 | 0.6635 | 0.1456 | |
| SRP007169 | ALOX5AP | 241 | RNAseq | 0.3201 | 0.5509 | |
| SRP008496 | ALOX5AP | 241 | RNAseq | 0.1723 | 0.6299 | |
| SRP064894 | ALOX5AP | 241 | RNAseq | 0.7580 | 0.0020 | |
| SRP133303 | ALOX5AP | 241 | RNAseq | 0.6475 | 0.0156 | |
| SRP159526 | ALOX5AP | 241 | RNAseq | -0.5429 | 0.4570 | |
| SRP193095 | ALOX5AP | 241 | RNAseq | 0.1623 | 0.4675 | |
| SRP219564 | ALOX5AP | 241 | RNAseq | 0.4948 | 0.3726 | |
| TCGA | ALOX5AP | 241 | RNAseq | 0.1400 | 0.2404 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ALOX5AP expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ALOX5AP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ALOX5AP | 241 | 1 | 14 | 15 | |
| GSE20123 | ALOX5AP | 241 | 1 | 13 | 16 | |
| GSE43470 | ALOX5AP | 241 | 2 | 12 | 29 | |
| GSE46452 | ALOX5AP | 241 | 0 | 33 | 26 | |
| GSE47630 | ALOX5AP | 241 | 2 | 27 | 11 | |
| GSE54993 | ALOX5AP | 241 | 12 | 2 | 56 | |
| GSE54994 | ALOX5AP | 241 | 2 | 15 | 36 | |
| GSE60625 | ALOX5AP | 241 | 0 | 3 | 8 | |
| GSE74703 | ALOX5AP | 241 | 2 | 9 | 25 | |
| GSE74704 | ALOX5AP | 241 | 0 | 11 | 9 | |
| TCGA | ALOX5AP | 241 | 8 | 37 | 51 |
Total number of gains: 30; Total number of losses: 176; Total Number of normals: 282.
Somatic mutations of ALOX5AP:
Generating mutation plots.
Highly correlated genes for ALOX5AP:
Showing top 20/373 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ALOX5AP | HLA-DRA | 0.716041 | 10 | 0 | 9 |
| ALOX5AP | CD86 | 0.707965 | 5 | 0 | 5 |
| ALOX5AP | PIK3CG | 0.694463 | 6 | 0 | 5 |
| ALOX5AP | PIK3AP1 | 0.690355 | 4 | 0 | 4 |
| ALOX5AP | ALOX5 | 0.682779 | 7 | 0 | 7 |
| ALOX5AP | DOK3 | 0.678127 | 4 | 0 | 4 |
| ALOX5AP | SNX12 | 0.674255 | 3 | 0 | 3 |
| ALOX5AP | PHACTR1 | 0.673947 | 4 | 0 | 3 |
| ALOX5AP | GPR65 | 0.671887 | 8 | 0 | 7 |
| ALOX5AP | LAPTM5 | 0.668263 | 12 | 0 | 9 |
| ALOX5AP | C19orf38 | 0.665001 | 3 | 0 | 3 |
| ALOX5AP | IKZF1 | 0.66091 | 7 | 0 | 7 |
| ALOX5AP | EVI2B | 0.656799 | 12 | 0 | 9 |
| ALOX5AP | SYS1 | 0.656611 | 3 | 0 | 3 |
| ALOX5AP | TNFRSF1B | 0.654138 | 9 | 0 | 7 |
| ALOX5AP | ITGAM | 0.651626 | 7 | 0 | 5 |
| ALOX5AP | TMEM176A | 0.650817 | 8 | 0 | 6 |
| ALOX5AP | UBL7 | 0.650539 | 3 | 0 | 3 |
| ALOX5AP | CD48 | 0.645167 | 11 | 0 | 10 |
| ALOX5AP | BTLA | 0.644937 | 4 | 0 | 4 |
For details and further investigation, click here
