| Full name: dual specificity phosphatase 7 | Alias Symbol: MKP-X|PYST2 | ||
| Type: protein-coding gene | Cytoband: 3p21.2 | ||
| Entrez ID: 1849 | HGNC ID: HGNC:3073 | Ensembl Gene: ENSG00000164086 | OMIM ID: 602749 |
| Drug and gene relationship at DGIdb | |||
DUSP7 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway |
Expression of DUSP7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DUSP7 | 1849 | 213848_at | 0.4925 | 0.4476 | |
| GSE20347 | DUSP7 | 1849 | 213848_at | -0.2899 | 0.3153 | |
| GSE23400 | DUSP7 | 1849 | 213848_at | 0.3011 | 0.0456 | |
| GSE26886 | DUSP7 | 1849 | 213848_at | 0.5091 | 0.0797 | |
| GSE29001 | DUSP7 | 1849 | 213848_at | -0.1089 | 0.7259 | |
| GSE38129 | DUSP7 | 1849 | 213848_at | 0.0759 | 0.8325 | |
| GSE45670 | DUSP7 | 1849 | 213848_at | 0.4222 | 0.0137 | |
| GSE53622 | DUSP7 | 1849 | 90122 | 0.1637 | 0.3183 | |
| GSE53624 | DUSP7 | 1849 | 90122 | -0.0064 | 0.9547 | |
| GSE63941 | DUSP7 | 1849 | 213848_at | 0.1325 | 0.7553 | |
| GSE77861 | DUSP7 | 1849 | 213848_at | 0.2636 | 0.1687 | |
| GSE97050 | DUSP7 | 1849 | A_24_P51855 | 0.7052 | 0.2259 | |
| SRP007169 | DUSP7 | 1849 | RNAseq | 0.9266 | 0.0854 | |
| SRP008496 | DUSP7 | 1849 | RNAseq | 0.5278 | 0.1368 | |
| SRP064894 | DUSP7 | 1849 | RNAseq | -0.0710 | 0.8234 | |
| SRP133303 | DUSP7 | 1849 | RNAseq | 0.2128 | 0.3937 | |
| SRP159526 | DUSP7 | 1849 | RNAseq | -0.4568 | 0.3730 | |
| SRP193095 | DUSP7 | 1849 | RNAseq | 0.3956 | 0.1571 | |
| SRP219564 | DUSP7 | 1849 | RNAseq | -0.7012 | 0.2733 | |
| TCGA | DUSP7 | 1849 | RNAseq | 0.4536 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DUSP7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DUSP7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DUSP7 | 1849 | 0 | 18 | 12 | |
| GSE20123 | DUSP7 | 1849 | 0 | 19 | 11 | |
| GSE43470 | DUSP7 | 1849 | 0 | 18 | 25 | |
| GSE46452 | DUSP7 | 1849 | 2 | 17 | 40 | |
| GSE47630 | DUSP7 | 1849 | 1 | 24 | 15 | |
| GSE54993 | DUSP7 | 1849 | 6 | 2 | 62 | |
| GSE54994 | DUSP7 | 1849 | 0 | 34 | 19 | |
| GSE60625 | DUSP7 | 1849 | 5 | 0 | 6 | |
| GSE74703 | DUSP7 | 1849 | 0 | 14 | 22 | |
| GSE74704 | DUSP7 | 1849 | 0 | 12 | 8 | |
| TCGA | DUSP7 | 1849 | 0 | 78 | 18 |
Total number of gains: 14; Total number of losses: 236; Total Number of normals: 238.
Somatic mutations of DUSP7:
Generating mutation plots.
Highly correlated genes for DUSP7:
Showing top 20/703 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DUSP7 | DOLK | 0.767115 | 3 | 0 | 3 |
| DUSP7 | FAM83A | 0.706275 | 5 | 0 | 5 |
| DUSP7 | SYT7 | 0.694539 | 3 | 0 | 3 |
| DUSP7 | NOTCH3 | 0.693476 | 6 | 0 | 5 |
| DUSP7 | MEN1 | 0.68981 | 4 | 0 | 3 |
| DUSP7 | MST1R | 0.688276 | 4 | 0 | 3 |
| DUSP7 | GJB3 | 0.688145 | 10 | 0 | 8 |
| DUSP7 | BCAR1 | 0.686094 | 5 | 0 | 5 |
| DUSP7 | BNC1 | 0.680798 | 12 | 0 | 9 |
| DUSP7 | STEAP1B | 0.68022 | 4 | 0 | 3 |
| DUSP7 | DARS2 | 0.677397 | 4 | 0 | 3 |
| DUSP7 | GNL3L | 0.676044 | 3 | 0 | 3 |
| DUSP7 | KIF23 | 0.672867 | 3 | 0 | 3 |
| DUSP7 | PHLDA2 | 0.672093 | 11 | 0 | 11 |
| DUSP7 | GEMIN6 | 0.67053 | 4 | 0 | 3 |
| DUSP7 | LSM5 | 0.668235 | 4 | 0 | 4 |
| DUSP7 | FHOD1 | 0.667923 | 5 | 0 | 5 |
| DUSP7 | SLC6A2 | 0.667489 | 4 | 0 | 3 |
| DUSP7 | B3GNT5 | 0.666016 | 6 | 0 | 6 |
| DUSP7 | C11orf80 | 0.665333 | 4 | 0 | 4 |
For details and further investigation, click here
