| Full name: methionyl aminopeptidase 2 | Alias Symbol: MNPEP|p67|MAP2 | ||
| Type: protein-coding gene | Cytoband: 12q22 | ||
| Entrez ID: 10988 | HGNC ID: HGNC:16672 | Ensembl Gene: ENSG00000111142 | OMIM ID: 601870 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of METAP2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | METAP2 | 10988 | 209861_s_at | 0.1055 | 0.6425 | |
| GSE20347 | METAP2 | 10988 | 209861_s_at | 0.2475 | 0.1293 | |
| GSE23400 | METAP2 | 10988 | 209861_s_at | 0.5291 | 0.0000 | |
| GSE26886 | METAP2 | 10988 | 209861_s_at | -0.2208 | 0.4527 | |
| GSE29001 | METAP2 | 10988 | 209861_s_at | 0.3579 | 0.4333 | |
| GSE38129 | METAP2 | 10988 | 209861_s_at | 0.2558 | 0.0155 | |
| GSE45670 | METAP2 | 10988 | 209861_s_at | 0.0241 | 0.8802 | |
| GSE53622 | METAP2 | 10988 | 93564 | 0.2914 | 0.0000 | |
| GSE53624 | METAP2 | 10988 | 93564 | 0.4249 | 0.0000 | |
| GSE63941 | METAP2 | 10988 | 209861_s_at | 0.3484 | 0.2449 | |
| GSE77861 | METAP2 | 10988 | 209861_s_at | 0.3154 | 0.3141 | |
| GSE97050 | METAP2 | 10988 | A_23_P99260 | 0.0874 | 0.7645 | |
| SRP007169 | METAP2 | 10988 | RNAseq | -0.1703 | 0.6411 | |
| SRP008496 | METAP2 | 10988 | RNAseq | 0.2762 | 0.1924 | |
| SRP064894 | METAP2 | 10988 | RNAseq | 0.0964 | 0.2869 | |
| SRP133303 | METAP2 | 10988 | RNAseq | 0.2716 | 0.0313 | |
| SRP159526 | METAP2 | 10988 | RNAseq | 0.0955 | 0.6722 | |
| SRP193095 | METAP2 | 10988 | RNAseq | 0.0652 | 0.6110 | |
| SRP219564 | METAP2 | 10988 | RNAseq | -0.2487 | 0.1228 | |
| TCGA | METAP2 | 10988 | RNAseq | 0.1357 | 0.0023 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by METAP2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of METAP2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | METAP2 | 10988 | 3 | 2 | 25 | |
| GSE20123 | METAP2 | 10988 | 3 | 2 | 25 | |
| GSE43470 | METAP2 | 10988 | 3 | 0 | 40 | |
| GSE46452 | METAP2 | 10988 | 9 | 1 | 49 | |
| GSE47630 | METAP2 | 10988 | 9 | 1 | 30 | |
| GSE54993 | METAP2 | 10988 | 0 | 5 | 65 | |
| GSE54994 | METAP2 | 10988 | 4 | 1 | 48 | |
| GSE60625 | METAP2 | 10988 | 0 | 0 | 11 | |
| GSE74703 | METAP2 | 10988 | 3 | 0 | 33 | |
| GSE74704 | METAP2 | 10988 | 1 | 2 | 17 | |
| TCGA | METAP2 | 10988 | 17 | 10 | 69 |
Total number of gains: 52; Total number of losses: 24; Total Number of normals: 412.
Somatic mutations of METAP2:
Generating mutation plots.
Highly correlated genes for METAP2:
Showing top 20/1131 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| METAP2 | SFR1 | 0.824236 | 3 | 0 | 3 |
| METAP2 | UQCRFS1 | 0.757996 | 3 | 0 | 3 |
| METAP2 | MRPL32 | 0.749318 | 4 | 0 | 4 |
| METAP2 | ZNF121 | 0.748356 | 3 | 0 | 3 |
| METAP2 | TTC37 | 0.74826 | 3 | 0 | 3 |
| METAP2 | FASTKD2 | 0.743955 | 6 | 0 | 5 |
| METAP2 | EBNA1BP2 | 0.740707 | 3 | 0 | 3 |
| METAP2 | PSMD1 | 0.73586 | 4 | 0 | 4 |
| METAP2 | PRRC1 | 0.735068 | 3 | 0 | 3 |
| METAP2 | LYPLAL1 | 0.733948 | 3 | 0 | 3 |
| METAP2 | CETN3 | 0.73327 | 3 | 0 | 3 |
| METAP2 | PSMA2 | 0.728069 | 8 | 0 | 7 |
| METAP2 | RPAIN | 0.715184 | 3 | 0 | 3 |
| METAP2 | VTI1B | 0.707261 | 3 | 0 | 3 |
| METAP2 | FAM98B | 0.705894 | 3 | 0 | 3 |
| METAP2 | VPS29 | 0.704949 | 3 | 0 | 3 |
| METAP2 | ARMC10 | 0.704934 | 4 | 0 | 4 |
| METAP2 | USPL1 | 0.701781 | 3 | 0 | 3 |
| METAP2 | EARS2 | 0.70081 | 3 | 0 | 3 |
| METAP2 | PSMD7 | 0.700188 | 6 | 0 | 5 |
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