| Full name: serine peptidase inhibitor, Kunitz type 1 | Alias Symbol: HAI|MANSC2 | ||
| Type: protein-coding gene | Cytoband: 15q15.1 | ||
| Entrez ID: 6692 | HGNC ID: HGNC:11246 | Ensembl Gene: ENSG00000166145 | OMIM ID: 605123 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SPINT1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPINT1 | 6692 | 202826_at | -0.7278 | 0.4845 | |
| GSE20347 | SPINT1 | 6692 | 202826_at | -1.3053 | 0.0000 | |
| GSE23400 | SPINT1 | 6692 | 202826_at | -1.0729 | 0.0000 | |
| GSE26886 | SPINT1 | 6692 | 202826_at | -1.2435 | 0.0008 | |
| GSE29001 | SPINT1 | 6692 | 202826_at | -1.2747 | 0.0002 | |
| GSE38129 | SPINT1 | 6692 | 202826_at | -0.4361 | 0.3080 | |
| GSE45670 | SPINT1 | 6692 | 202826_at | -0.5573 | 0.0763 | |
| GSE53622 | SPINT1 | 6692 | 24042 | -0.7673 | 0.0000 | |
| GSE53624 | SPINT1 | 6692 | 24042 | -0.9717 | 0.0000 | |
| GSE63941 | SPINT1 | 6692 | 202826_at | 3.9000 | 0.0005 | |
| GSE77861 | SPINT1 | 6692 | 202826_at | -0.8297 | 0.0035 | |
| GSE97050 | SPINT1 | 6692 | A_23_P49060 | -0.2852 | 0.7545 | |
| SRP007169 | SPINT1 | 6692 | RNAseq | -3.4794 | 0.0000 | |
| SRP008496 | SPINT1 | 6692 | RNAseq | -3.6213 | 0.0000 | |
| SRP064894 | SPINT1 | 6692 | RNAseq | -2.0510 | 0.0000 | |
| SRP133303 | SPINT1 | 6692 | RNAseq | -1.1876 | 0.0000 | |
| SRP159526 | SPINT1 | 6692 | RNAseq | -1.5875 | 0.0000 | |
| SRP193095 | SPINT1 | 6692 | RNAseq | -1.4020 | 0.0000 | |
| SRP219564 | SPINT1 | 6692 | RNAseq | -2.0359 | 0.0614 | |
| TCGA | SPINT1 | 6692 | RNAseq | 0.2147 | 0.0357 |
Upregulated datasets: 1; Downregulated datasets: 10.
Survival by SPINT1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPINT1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPINT1 | 6692 | 3 | 6 | 21 | |
| GSE20123 | SPINT1 | 6692 | 3 | 6 | 21 | |
| GSE43470 | SPINT1 | 6692 | 4 | 6 | 33 | |
| GSE46452 | SPINT1 | 6692 | 3 | 7 | 49 | |
| GSE47630 | SPINT1 | 6692 | 8 | 11 | 21 | |
| GSE54993 | SPINT1 | 6692 | 4 | 6 | 60 | |
| GSE54994 | SPINT1 | 6692 | 5 | 7 | 41 | |
| GSE60625 | SPINT1 | 6692 | 4 | 0 | 7 | |
| GSE74703 | SPINT1 | 6692 | 4 | 5 | 27 | |
| GSE74704 | SPINT1 | 6692 | 2 | 4 | 14 | |
| TCGA | SPINT1 | 6692 | 11 | 18 | 67 |
Total number of gains: 51; Total number of losses: 76; Total Number of normals: 361.
Somatic mutations of SPINT1:
Generating mutation plots.
Highly correlated genes for SPINT1:
Showing top 20/1303 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPINT1 | CHP1 | 0.800796 | 10 | 0 | 10 |
| SPINT1 | CXADR | 0.798033 | 3 | 0 | 3 |
| SPINT1 | PRSS8 | 0.797377 | 9 | 0 | 9 |
| SPINT1 | RAB25 | 0.771063 | 13 | 0 | 13 |
| SPINT1 | EPS8L2 | 0.769923 | 10 | 0 | 10 |
| SPINT1 | EVPL | 0.764421 | 12 | 0 | 12 |
| SPINT1 | RAB11A | 0.759948 | 12 | 0 | 12 |
| SPINT1 | TJP3 | 0.757873 | 12 | 0 | 12 |
| SPINT1 | PTK6 | 0.757657 | 11 | 0 | 11 |
| SPINT1 | SH3GL1 | 0.75692 | 11 | 0 | 11 |
| SPINT1 | MPZL3 | 0.756587 | 8 | 0 | 8 |
| SPINT1 | USP6NL | 0.755112 | 11 | 0 | 11 |
| SPINT1 | GLTP | 0.754347 | 9 | 0 | 9 |
| SPINT1 | AGFG2 | 0.753931 | 10 | 0 | 10 |
| SPINT1 | MYO5B | 0.753229 | 7 | 0 | 7 |
| SPINT1 | ERBB3 | 0.75315 | 12 | 0 | 12 |
| SPINT1 | PRSS2 | 0.747771 | 8 | 0 | 8 |
| SPINT1 | CLIC3 | 0.747266 | 10 | 0 | 9 |
| SPINT1 | ARHGAP27 | 0.747134 | 9 | 0 | 8 |
| SPINT1 | TTC9 | 0.741117 | 12 | 0 | 12 |
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