TMEM33

 

Full name: transmembrane protein 33 Alias Symbol: FLJ10525|Pom33
Type: protein-coding gene Cytoband: 4p13
Entrez ID: 55161 HGNC ID: HGNC:25541 Ensembl Gene: ENSG00000109133 OMIM ID: 
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of TMEM33:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TMEM33 55161 225492_at 0.5409 0.4022
GSE20347 TMEM33 55161 218465_at -0.3943 0.0115
GSE23400 TMEM33 55161 218465_at 0.2347 0.0106
GSE26886 TMEM33 55161 225492_at -0.7301 0.0094
GSE29001 TMEM33 55161 218465_at 0.1229 0.7669
GSE38129 TMEM33 55161 218465_at 0.0936 0.5919
GSE45670 TMEM33 55161 225492_at 0.3910 0.0038
GSE53622 TMEM33 55161 90871 -0.1402 0.1332
GSE53624 TMEM33 55161 90871 -0.0999 0.3684
GSE63941 TMEM33 55161 225492_at 0.1481 0.7414
GSE77861 TMEM33 55161 225492_at -0.0949 0.7024
GSE97050 TMEM33 55161 A_24_P191790 0.1345 0.6850
SRP007169 TMEM33 55161 RNAseq -0.1728 0.6021
SRP008496 TMEM33 55161 RNAseq -0.2733 0.1727
SRP064894 TMEM33 55161 RNAseq 0.0372 0.8021
SRP133303 TMEM33 55161 RNAseq 0.2307 0.1026
SRP159526 TMEM33 55161 RNAseq -0.1404 0.4165
SRP193095 TMEM33 55161 RNAseq -0.3687 0.0010
SRP219564 TMEM33 55161 RNAseq 0.5621 0.2713
TCGA TMEM33 55161 RNAseq 0.0148 0.7598

Upregulated datasets: 0; Downregulated datasets: 0.  


 

Survival by TMEM33 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  


Copy number change of TMEM33:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TMEM33 55161 0 16 14
GSE20123 TMEM33 55161 0 16 14
GSE43470 TMEM33 55161 0 14 29
GSE46452 TMEM33 55161 1 36 22
GSE47630 TMEM33 55161 1 19 20
GSE54993 TMEM33 55161 7 0 63
GSE54994 TMEM33 55161 4 9 40
GSE60625 TMEM33 55161 0 0 11
GSE74703 TMEM33 55161 0 12 24
GSE74704 TMEM33 55161 0 9 11
TCGA TMEM33 55161 11 42 43

Total number of gains: 24; Total number of losses: 173; Total Number of normals: 291.  


 

Somatic mutations of TMEM33:

 

Generating mutation plots.

 

Highly correlated genes for TMEM33:

 

Showing top 20/211 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TMEM33SRP190.706066606
TMEM33BOD1L10.688984303
TMEM33UBXN2A0.664497303
TMEM33PLEKHF20.662951404
TMEM33SNRNP2000.658664303
TMEM33RAPGEF40.654342303
TMEM33SLC39A80.651354403
TMEM33DCTN50.649531403
TMEM33STON20.644287303
TMEM33RIPK30.641646303
TMEM33DPYD0.638232504
TMEM33TPMT0.637802303
TMEM33C12orf750.637083303
TMEM33NAA200.631805404
TMEM33GTF2F20.622915403
TMEM33TSKU0.622665403
TMEM33GPD20.617157504
TMEM33TMED20.606731503
TMEM33NAB10.606173303
TMEM33GK50.605577403

For details and further investigation, click here