| Full name: leucine rich alpha-2-glycoprotein 1 | Alias Symbol: LRG | ||
| Type: protein-coding gene | Cytoband: 19p13.3 | ||
| Entrez ID: 116844 | HGNC ID: HGNC:29480 | Ensembl Gene: ENSG00000171236 | OMIM ID: 611289 |
| Drug and gene relationship at DGIdb | |||
Expression of LRG1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LRG1 | 116844 | 228648_at | -1.0029 | 0.3210 | |
| GSE26886 | LRG1 | 116844 | 228648_at | -2.1464 | 0.0001 | |
| GSE45670 | LRG1 | 116844 | 228648_at | 0.9782 | 0.0181 | |
| GSE53622 | LRG1 | 116844 | 80849 | -0.4392 | 0.0055 | |
| GSE53624 | LRG1 | 116844 | 80849 | -0.9008 | 0.0000 | |
| GSE63941 | LRG1 | 116844 | 228648_at | 1.6213 | 0.2137 | |
| GSE77861 | LRG1 | 116844 | 228648_at | -1.0240 | 0.0183 | |
| GSE97050 | LRG1 | 116844 | A_23_P50638 | 0.4563 | 0.1313 | |
| SRP007169 | LRG1 | 116844 | RNAseq | -2.4630 | 0.0006 | |
| SRP008496 | LRG1 | 116844 | RNAseq | -3.6989 | 0.0000 | |
| SRP064894 | LRG1 | 116844 | RNAseq | -1.0234 | 0.0176 | |
| SRP133303 | LRG1 | 116844 | RNAseq | -0.3194 | 0.4457 | |
| SRP159526 | LRG1 | 116844 | RNAseq | -3.0620 | 0.0018 | |
| SRP193095 | LRG1 | 116844 | RNAseq | -1.3828 | 0.0000 | |
| SRP219564 | LRG1 | 116844 | RNAseq | -2.5165 | 0.0099 | |
| TCGA | LRG1 | 116844 | RNAseq | -0.5362 | 0.0922 |
Upregulated datasets: 0; Downregulated datasets: 8.
Survival by LRG1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LRG1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LRG1 | 116844 | 5 | 3 | 22 | |
| GSE20123 | LRG1 | 116844 | 4 | 2 | 24 | |
| GSE43470 | LRG1 | 116844 | 1 | 8 | 34 | |
| GSE46452 | LRG1 | 116844 | 47 | 1 | 11 | |
| GSE47630 | LRG1 | 116844 | 5 | 7 | 28 | |
| GSE54993 | LRG1 | 116844 | 16 | 3 | 51 | |
| GSE54994 | LRG1 | 116844 | 6 | 16 | 31 | |
| GSE60625 | LRG1 | 116844 | 9 | 0 | 2 | |
| GSE74703 | LRG1 | 116844 | 1 | 5 | 30 | |
| GSE74704 | LRG1 | 116844 | 1 | 2 | 17 | |
| TCGA | LRG1 | 116844 | 12 | 18 | 66 |
Total number of gains: 107; Total number of losses: 65; Total Number of normals: 316.
Somatic mutations of LRG1:
Generating mutation plots.
Highly correlated genes for LRG1:
Showing top 20/612 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LRG1 | CCL28 | 0.690999 | 3 | 0 | 3 |
| LRG1 | PRPSAP1 | 0.673895 | 3 | 0 | 3 |
| LRG1 | UBE2J1 | 0.672184 | 4 | 0 | 4 |
| LRG1 | SEC24C | 0.668751 | 4 | 0 | 4 |
| LRG1 | FCGBP | 0.668108 | 5 | 0 | 4 |
| LRG1 | CCDC85C | 0.666242 | 3 | 0 | 3 |
| LRG1 | FUCA1 | 0.664061 | 3 | 0 | 3 |
| LRG1 | IL22RA1 | 0.662473 | 4 | 0 | 4 |
| LRG1 | ATP6V0A4 | 0.661289 | 6 | 0 | 5 |
| LRG1 | CARHSP1 | 0.660527 | 7 | 0 | 6 |
| LRG1 | CEACAM7 | 0.6598 | 6 | 0 | 5 |
| LRG1 | ARHGEF18 | 0.659748 | 3 | 0 | 3 |
| LRG1 | DPYD | 0.65773 | 4 | 0 | 3 |
| LRG1 | RAB27A | 0.656554 | 6 | 0 | 4 |
| LRG1 | KLRB1 | 0.65647 | 5 | 0 | 4 |
| LRG1 | CPVL | 0.654202 | 4 | 0 | 3 |
| LRG1 | CPM | 0.652965 | 4 | 0 | 4 |
| LRG1 | PDIK1L | 0.650951 | 3 | 0 | 3 |
| LRG1 | TM9SF4 | 0.650076 | 4 | 0 | 3 |
| LRG1 | FAM71C | 0.648546 | 3 | 0 | 3 |
For details and further investigation, click here
