| Full name: dopamine receptor D1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 5q35.2 | ||
| Entrez ID: 1812 | HGNC ID: HGNC:3020 | Ensembl Gene: ENSG00000184845 | OMIM ID: 126449 |
| Related drugs: ACEPROMAZINE, ACETOPHENAZINE, AMOXAPINE, APOMORPHINE, ASENAPINE (CHEMBL3187365), BROMOCRIPTINE, CABERGOLINE, CARPHENAZINE, CHEMBL1255588, CHEMBL13668... [more] | |||
DRD1 involved pathways:
Expression of DRD1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DRD1 | 1812 | 214652_at | 0.1777 | 0.3880 | |
| GSE20347 | DRD1 | 1812 | 214652_at | 0.0375 | 0.5003 | |
| GSE23400 | DRD1 | 1812 | 214652_at | -0.0908 | 0.0058 | |
| GSE26886 | DRD1 | 1812 | 214652_at | 0.1320 | 0.1351 | |
| GSE29001 | DRD1 | 1812 | 214652_at | -0.0872 | 0.4482 | |
| GSE38129 | DRD1 | 1812 | 214652_at | -0.0149 | 0.8133 | |
| GSE45670 | DRD1 | 1812 | 214652_at | -0.0801 | 0.2288 | |
| GSE53622 | DRD1 | 1812 | 80338 | -1.1521 | 0.0000 | |
| GSE53624 | DRD1 | 1812 | 80338 | -1.4038 | 0.0000 | |
| GSE63941 | DRD1 | 1812 | 214652_at | -0.0666 | 0.6017 | |
| GSE77861 | DRD1 | 1812 | 214652_at | 0.0662 | 0.3892 | |
| SRP133303 | DRD1 | 1812 | RNAseq | -2.0038 | 0.0000 | |
| TCGA | DRD1 | 1812 | RNAseq | -1.1074 | 0.0587 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by DRD1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DRD1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DRD1 | 1812 | 2 | 12 | 16 | |
| GSE20123 | DRD1 | 1812 | 2 | 12 | 16 | |
| GSE43470 | DRD1 | 1812 | 1 | 10 | 32 | |
| GSE46452 | DRD1 | 1812 | 0 | 27 | 32 | |
| GSE47630 | DRD1 | 1812 | 0 | 20 | 20 | |
| GSE54993 | DRD1 | 1812 | 10 | 2 | 58 | |
| GSE54994 | DRD1 | 1812 | 2 | 17 | 34 | |
| GSE60625 | DRD1 | 1812 | 1 | 0 | 10 | |
| GSE74703 | DRD1 | 1812 | 1 | 7 | 28 | |
| GSE74704 | DRD1 | 1812 | 1 | 6 | 13 | |
| TCGA | DRD1 | 1812 | 7 | 35 | 54 |
Total number of gains: 27; Total number of losses: 148; Total Number of normals: 313.
Somatic mutations of DRD1:
Generating mutation plots.
Highly correlated genes for DRD1:
Showing top 20/60 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DRD1 | SEMA4G | 0.662423 | 3 | 0 | 3 |
| DRD1 | DMC1 | 0.641552 | 3 | 0 | 3 |
| DRD1 | NPHP1 | 0.640203 | 4 | 0 | 3 |
| DRD1 | CRTC2 | 0.636235 | 3 | 0 | 3 |
| DRD1 | CTAGE1 | 0.628289 | 3 | 0 | 3 |
| DRD1 | TAS2R7 | 0.626258 | 3 | 0 | 3 |
| DRD1 | JAK3 | 0.623639 | 3 | 0 | 3 |
| DRD1 | TAF1 | 0.62307 | 4 | 0 | 3 |
| DRD1 | IFT122 | 0.616473 | 3 | 0 | 3 |
| DRD1 | PLEC | 0.605081 | 3 | 0 | 3 |
| DRD1 | GK2 | 0.601536 | 3 | 0 | 3 |
| DRD1 | GRK4 | 0.596693 | 5 | 0 | 3 |
| DRD1 | VAX2 | 0.596542 | 3 | 0 | 3 |
| DRD1 | REC8 | 0.594933 | 3 | 0 | 3 |
| DRD1 | MUC5AC | 0.592176 | 4 | 0 | 4 |
| DRD1 | ZNF221 | 0.590893 | 3 | 0 | 3 |
| DRD1 | SCGN | 0.590479 | 3 | 0 | 3 |
| DRD1 | ASH1L | 0.588997 | 3 | 0 | 3 |
| DRD1 | PPP1R37 | 0.586436 | 3 | 0 | 3 |
| DRD1 | STK11 | 0.586007 | 3 | 0 | 3 |
For details and further investigation, click here
