| Full name: developmentally regulated GTP binding protein 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 22q12.2 | ||
| Entrez ID: 4733 | HGNC ID: HGNC:3029 | Ensembl Gene: ENSG00000185721 | OMIM ID: 603952 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of DRG1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DRG1 | 4733 | 202810_at | 0.1249 | 0.6126 | |
| GSE20347 | DRG1 | 4733 | 202810_at | 0.2343 | 0.0974 | |
| GSE23400 | DRG1 | 4733 | 202810_at | 0.3110 | 0.0000 | |
| GSE26886 | DRG1 | 4733 | 202810_at | -0.2428 | 0.0565 | |
| GSE29001 | DRG1 | 4733 | 202810_at | 0.2865 | 0.1375 | |
| GSE38129 | DRG1 | 4733 | 202810_at | 0.2204 | 0.0240 | |
| GSE45670 | DRG1 | 4733 | 202810_at | 0.2684 | 0.1411 | |
| GSE53622 | DRG1 | 4733 | 91397 | 0.3773 | 0.0000 | |
| GSE53624 | DRG1 | 4733 | 91397 | 0.4485 | 0.0000 | |
| GSE63941 | DRG1 | 4733 | 202810_at | 0.5100 | 0.0252 | |
| GSE77861 | DRG1 | 4733 | 202810_at | 0.3629 | 0.1524 | |
| GSE97050 | DRG1 | 4733 | A_23_P68884 | 0.1037 | 0.5688 | |
| SRP007169 | DRG1 | 4733 | RNAseq | 0.1418 | 0.6488 | |
| SRP008496 | DRG1 | 4733 | RNAseq | 0.2624 | 0.3876 | |
| SRP064894 | DRG1 | 4733 | RNAseq | 0.4414 | 0.0314 | |
| SRP133303 | DRG1 | 4733 | RNAseq | 0.2206 | 0.2012 | |
| SRP159526 | DRG1 | 4733 | RNAseq | 0.4704 | 0.0049 | |
| SRP193095 | DRG1 | 4733 | RNAseq | 0.0431 | 0.7121 | |
| SRP219564 | DRG1 | 4733 | RNAseq | 0.4021 | 0.2758 | |
| TCGA | DRG1 | 4733 | RNAseq | 0.1468 | 0.0040 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DRG1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DRG1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DRG1 | 4733 | 4 | 5 | 21 | |
| GSE20123 | DRG1 | 4733 | 4 | 4 | 22 | |
| GSE43470 | DRG1 | 4733 | 4 | 5 | 34 | |
| GSE46452 | DRG1 | 4733 | 31 | 1 | 27 | |
| GSE47630 | DRG1 | 4733 | 8 | 5 | 27 | |
| GSE54993 | DRG1 | 4733 | 3 | 6 | 61 | |
| GSE54994 | DRG1 | 4733 | 12 | 8 | 33 | |
| GSE60625 | DRG1 | 4733 | 5 | 0 | 6 | |
| GSE74703 | DRG1 | 4733 | 4 | 5 | 27 | |
| GSE74704 | DRG1 | 4733 | 1 | 1 | 18 | |
| TCGA | DRG1 | 4733 | 27 | 16 | 53 |
Total number of gains: 103; Total number of losses: 56; Total Number of normals: 329.
Somatic mutations of DRG1:
Generating mutation plots.
Highly correlated genes for DRG1:
Showing top 20/932 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DRG1 | GPR107 | 0.736178 | 3 | 0 | 3 |
| DRG1 | THOC5 | 0.728701 | 11 | 0 | 11 |
| DRG1 | TLR1 | 0.697284 | 4 | 0 | 3 |
| DRG1 | ZBTB8OS | 0.692113 | 4 | 0 | 4 |
| DRG1 | KATNA1 | 0.691796 | 8 | 0 | 8 |
| DRG1 | ANKRD50 | 0.689734 | 3 | 0 | 3 |
| DRG1 | MZT1 | 0.687092 | 3 | 0 | 3 |
| DRG1 | ERG | 0.687062 | 3 | 0 | 3 |
| DRG1 | GLUD2 | 0.687047 | 3 | 0 | 3 |
| DRG1 | RTCB | 0.684001 | 11 | 0 | 10 |
| DRG1 | RDX | 0.677811 | 3 | 0 | 3 |
| DRG1 | CNTNAP2 | 0.67679 | 3 | 0 | 3 |
| DRG1 | BLCAP | 0.674028 | 3 | 0 | 3 |
| DRG1 | RABAC1 | 0.66962 | 3 | 0 | 3 |
| DRG1 | PSMC1 | 0.666744 | 8 | 0 | 6 |
| DRG1 | G2E3 | 0.665788 | 5 | 0 | 5 |
| DRG1 | SPPL2A | 0.663082 | 5 | 0 | 5 |
| DRG1 | MNAT1 | 0.661081 | 9 | 0 | 8 |
| DRG1 | SRI | 0.657839 | 4 | 0 | 4 |
| DRG1 | ZNHIT3 | 0.657695 | 9 | 0 | 8 |
For details and further investigation, click here
