| Full name: radixin | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 11q23 | ||
| Entrez ID: 5962 | HGNC ID: HGNC:9944 | Ensembl Gene: ENSG00000137710 | OMIM ID: 179410 |
| Drug and gene relationship at DGIdb | |||
RDX involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04810 | Regulation of actin cytoskeleton | |
| hsa05205 | Proteoglycans in cancer |
Expression of RDX:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RDX | 5962 | 212397_at | -0.5323 | 0.1799 | |
| GSE20347 | RDX | 5962 | 212397_at | -0.4276 | 0.0421 | |
| GSE23400 | RDX | 5962 | 212397_at | -0.1423 | 0.1693 | |
| GSE26886 | RDX | 5962 | 212397_at | -1.2080 | 0.0001 | |
| GSE29001 | RDX | 5962 | 212397_at | -0.4847 | 0.1196 | |
| GSE38129 | RDX | 5962 | 212397_at | -0.5946 | 0.0009 | |
| GSE45670 | RDX | 5962 | 212397_at | -0.5237 | 0.0010 | |
| GSE53622 | RDX | 5962 | 13323 | -0.2746 | 0.0002 | |
| GSE53624 | RDX | 5962 | 13323 | -0.2111 | 0.0016 | |
| GSE63941 | RDX | 5962 | 212397_at | -0.5105 | 0.2219 | |
| GSE77861 | RDX | 5962 | 212397_at | 0.1537 | 0.6421 | |
| GSE97050 | RDX | 5962 | A_23_P203023 | -0.4199 | 0.1834 | |
| SRP007169 | RDX | 5962 | RNAseq | -0.5627 | 0.1557 | |
| SRP008496 | RDX | 5962 | RNAseq | -0.3940 | 0.0905 | |
| SRP064894 | RDX | 5962 | RNAseq | -0.2281 | 0.3259 | |
| SRP133303 | RDX | 5962 | RNAseq | 0.0258 | 0.8757 | |
| SRP159526 | RDX | 5962 | RNAseq | -0.2561 | 0.3918 | |
| SRP193095 | RDX | 5962 | RNAseq | -0.2478 | 0.1289 | |
| SRP219564 | RDX | 5962 | RNAseq | -0.3452 | 0.3135 | |
| TCGA | RDX | 5962 | RNAseq | -0.0882 | 0.0822 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by RDX expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RDX:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RDX | 5962 | 0 | 13 | 17 | |
| GSE20123 | RDX | 5962 | 0 | 13 | 17 | |
| GSE43470 | RDX | 5962 | 2 | 6 | 35 | |
| GSE46452 | RDX | 5962 | 3 | 26 | 30 | |
| GSE47630 | RDX | 5962 | 2 | 19 | 19 | |
| GSE54993 | RDX | 5962 | 9 | 1 | 60 | |
| GSE54994 | RDX | 5962 | 5 | 19 | 29 | |
| GSE60625 | RDX | 5962 | 0 | 3 | 8 | |
| GSE74703 | RDX | 5962 | 1 | 4 | 31 | |
| GSE74704 | RDX | 5962 | 0 | 9 | 11 | |
| TCGA | RDX | 5962 | 6 | 47 | 43 |
Total number of gains: 28; Total number of losses: 160; Total Number of normals: 300.
Somatic mutations of RDX:
Generating mutation plots.
Highly correlated genes for RDX:
Showing top 20/735 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RDX | MAP3K8 | 0.775832 | 3 | 0 | 3 |
| RDX | SLMAP | 0.735091 | 5 | 0 | 5 |
| RDX | DCAF10 | 0.728973 | 3 | 0 | 3 |
| RDX | FUNDC2 | 0.72192 | 3 | 0 | 3 |
| RDX | ZRANB2 | 0.717661 | 3 | 0 | 3 |
| RDX | TM4SF18 | 0.714688 | 3 | 0 | 3 |
| RDX | DNAJA2 | 0.710149 | 5 | 0 | 3 |
| RDX | IBTK | 0.710044 | 3 | 0 | 3 |
| RDX | ACAT1 | 0.697396 | 13 | 0 | 13 |
| RDX | TRIP4 | 0.695465 | 5 | 0 | 4 |
| RDX | HOXA4 | 0.694872 | 5 | 0 | 4 |
| RDX | ARIH1 | 0.69241 | 3 | 0 | 3 |
| RDX | TRIM22 | 0.687881 | 3 | 0 | 3 |
| RDX | ARGLU1 | 0.684661 | 3 | 0 | 3 |
| RDX | CGGBP1 | 0.683959 | 6 | 0 | 5 |
| RDX | FAM83D | 0.682198 | 4 | 0 | 3 |
| RDX | KLF4 | 0.678079 | 4 | 0 | 4 |
| RDX | DRG1 | 0.677811 | 3 | 0 | 3 |
| RDX | COPS2 | 0.672909 | 5 | 0 | 4 |
| RDX | CD2AP | 0.672174 | 6 | 0 | 5 |
For details and further investigation, click here
