| Full name: ETS transcription factor ERG | Alias Symbol: erg-3|p55 | ||
| Type: protein-coding gene | Cytoband: 21q22.2 | ||
| Entrez ID: 2078 | HGNC ID: HGNC:3446 | Ensembl Gene: ENSG00000157554 | OMIM ID: 165080 |
| Drug and gene relationship at DGIdb | |||
Expression of ERG:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ERG | 2078 | 213541_s_at | -0.2514 | 0.6921 | |
| GSE20347 | ERG | 2078 | 211626_x_at | 0.1627 | 0.0541 | |
| GSE23400 | ERG | 2078 | 211626_x_at | -0.0066 | 0.8802 | |
| GSE26886 | ERG | 2078 | 213541_s_at | 0.1807 | 0.6724 | |
| GSE29001 | ERG | 2078 | 213541_s_at | 0.5278 | 0.1778 | |
| GSE38129 | ERG | 2078 | 213541_s_at | -0.0874 | 0.7549 | |
| GSE45670 | ERG | 2078 | 213541_s_at | -0.3836 | 0.1631 | |
| GSE53622 | ERG | 2078 | 65665 | -0.4269 | 0.0000 | |
| GSE53624 | ERG | 2078 | 65665 | -0.0360 | 0.7694 | |
| GSE63941 | ERG | 2078 | 211626_x_at | 0.1933 | 0.2931 | |
| GSE77861 | ERG | 2078 | 213541_s_at | 0.1352 | 0.4450 | |
| GSE97050 | ERG | 2078 | A_23_P301414 | 0.0904 | 0.7805 | |
| SRP007169 | ERG | 2078 | RNAseq | 3.1436 | 0.0071 | |
| SRP064894 | ERG | 2078 | RNAseq | 0.6886 | 0.0121 | |
| SRP133303 | ERG | 2078 | RNAseq | -0.4957 | 0.0399 | |
| SRP159526 | ERG | 2078 | RNAseq | 0.0630 | 0.8642 | |
| SRP193095 | ERG | 2078 | RNAseq | 1.2768 | 0.0000 | |
| SRP219564 | ERG | 2078 | RNAseq | 0.2236 | 0.5526 | |
| TCGA | ERG | 2078 | RNAseq | -0.2363 | 0.0213 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by ERG expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ERG:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ERG | 2078 | 2 | 9 | 19 | |
| GSE20123 | ERG | 2078 | 2 | 9 | 19 | |
| GSE43470 | ERG | 2078 | 1 | 10 | 32 | |
| GSE46452 | ERG | 2078 | 1 | 21 | 37 | |
| GSE47630 | ERG | 2078 | 6 | 17 | 17 | |
| GSE54993 | ERG | 2078 | 8 | 1 | 61 | |
| GSE54994 | ERG | 2078 | 3 | 9 | 41 | |
| GSE60625 | ERG | 2078 | 0 | 0 | 11 | |
| GSE74703 | ERG | 2078 | 1 | 8 | 27 | |
| GSE74704 | ERG | 2078 | 1 | 6 | 13 | |
| TCGA | ERG | 2078 | 8 | 41 | 47 |
Total number of gains: 33; Total number of losses: 131; Total Number of normals: 324.
Somatic mutations of ERG:
Generating mutation plots.
Highly correlated genes for ERG:
Showing top 20/272 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ERG | RTN4IP1 | 0.774172 | 3 | 0 | 3 |
| ERG | TMEM107 | 0.766174 | 3 | 0 | 3 |
| ERG | ING1 | 0.742887 | 3 | 0 | 3 |
| ERG | TCF7L1 | 0.737143 | 3 | 0 | 3 |
| ERG | PLEKHA8 | 0.735126 | 3 | 0 | 3 |
| ERG | SLC25A14 | 0.713025 | 3 | 0 | 3 |
| ERG | SLC15A4 | 0.696145 | 3 | 0 | 3 |
| ERG | SMC5 | 0.694574 | 3 | 0 | 3 |
| ERG | DCHS1 | 0.692743 | 4 | 0 | 4 |
| ERG | RNASE4 | 0.692018 | 3 | 0 | 3 |
| ERG | DRG1 | 0.687062 | 3 | 0 | 3 |
| ERG | TMEM60 | 0.686389 | 4 | 0 | 3 |
| ERG | KIAA2013 | 0.685746 | 3 | 0 | 3 |
| ERG | COG8 | 0.685746 | 3 | 0 | 3 |
| ERG | ECSCR | 0.685369 | 5 | 0 | 5 |
| ERG | BORA | 0.68399 | 3 | 0 | 3 |
| ERG | DMXL2 | 0.683107 | 3 | 0 | 3 |
| ERG | KDM3A | 0.680593 | 3 | 0 | 3 |
| ERG | SMCR8 | 0.678881 | 3 | 0 | 3 |
| ERG | CD109 | 0.677802 | 4 | 0 | 3 |
For details and further investigation, click here
