| Full name: desmoglein 1 | Alias Symbol: CDHF4 | ||
| Type: protein-coding gene | Cytoband: 18q12.1 | ||
| Entrez ID: 1828 | HGNC ID: HGNC:3048 | Ensembl Gene: ENSG00000134760 | OMIM ID: 125670 |
| Drug and gene relationship at DGIdb | |||
Expression of DSG1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DSG1 | 1828 | 206642_at | -1.9878 | 0.3747 | |
| GSE20347 | DSG1 | 1828 | 206642_at | -3.3438 | 0.0000 | |
| GSE23400 | DSG1 | 1828 | 206642_at | -0.5829 | 0.0904 | |
| GSE26886 | DSG1 | 1828 | 206642_at | -3.2578 | 0.0003 | |
| GSE29001 | DSG1 | 1828 | 206642_at | -1.2238 | 0.2260 | |
| GSE38129 | DSG1 | 1828 | 206642_at | -1.9374 | 0.0022 | |
| GSE45670 | DSG1 | 1828 | 206642_at | -0.6940 | 0.3904 | |
| GSE63941 | DSG1 | 1828 | 206642_at | 0.4457 | 0.2258 | |
| GSE77861 | DSG1 | 1828 | 206642_at | -1.3776 | 0.1645 | |
| SRP007169 | DSG1 | 1828 | RNAseq | -2.9347 | 0.0000 | |
| SRP008496 | DSG1 | 1828 | RNAseq | -1.4361 | 0.0905 | |
| SRP064894 | DSG1 | 1828 | RNAseq | -2.2950 | 0.0011 | |
| SRP133303 | DSG1 | 1828 | RNAseq | -2.7631 | 0.0017 | |
| SRP219564 | DSG1 | 1828 | RNAseq | -4.8088 | 0.0001 | |
| TCGA | DSG1 | 1828 | RNAseq | 0.8073 | 0.0645 |
Upregulated datasets: 0; Downregulated datasets: 7.
Survival by DSG1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of DSG1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DSG1 | 1828 | 3 | 6 | 21 | |
| GSE20123 | DSG1 | 1828 | 3 | 6 | 21 | |
| GSE43470 | DSG1 | 1828 | 0 | 2 | 41 | |
| GSE46452 | DSG1 | 1828 | 1 | 25 | 33 | |
| GSE47630 | DSG1 | 1828 | 5 | 20 | 15 | |
| GSE54993 | DSG1 | 1828 | 7 | 1 | 62 | |
| GSE54994 | DSG1 | 1828 | 2 | 16 | 35 | |
| GSE60625 | DSG1 | 1828 | 0 | 4 | 7 | |
| GSE74703 | DSG1 | 1828 | 0 | 2 | 34 | |
| GSE74704 | DSG1 | 1828 | 1 | 5 | 14 | |
| TCGA | DSG1 | 1828 | 14 | 36 | 46 |
Total number of gains: 36; Total number of losses: 123; Total Number of normals: 329.
Somatic mutations of DSG1:
Generating mutation plots.
Highly correlated genes for DSG1:
Showing top 20/846 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DSG1 | GBP6 | 0.784859 | 3 | 0 | 3 |
| DSG1 | SBSN | 0.75252 | 5 | 0 | 5 |
| DSG1 | CAPN14 | 0.73897 | 3 | 0 | 3 |
| DSG1 | PELI1 | 0.721358 | 5 | 0 | 5 |
| DSG1 | WDR41 | 0.720302 | 3 | 0 | 3 |
| DSG1 | TMPRSS11B | 0.71967 | 3 | 0 | 3 |
| DSG1 | EHD3 | 0.714544 | 5 | 0 | 5 |
| DSG1 | DYNLT3 | 0.713972 | 5 | 0 | 4 |
| DSG1 | CNEP1R1 | 0.710729 | 3 | 0 | 3 |
| DSG1 | USH1G | 0.708287 | 3 | 0 | 3 |
| DSG1 | ACOX1 | 0.704387 | 4 | 0 | 4 |
| DSG1 | SPRR3 | 0.700544 | 7 | 0 | 6 |
| DSG1 | FAM135A | 0.699804 | 3 | 0 | 3 |
| DSG1 | CRCT1 | 0.694337 | 10 | 0 | 9 |
| DSG1 | PTGR1 | 0.693613 | 3 | 0 | 3 |
| DSG1 | IVL | 0.693439 | 9 | 0 | 9 |
| DSG1 | TRIM7 | 0.692599 | 3 | 0 | 3 |
| DSG1 | ALDH3A2 | 0.691353 | 5 | 0 | 5 |
| DSG1 | CLINT1 | 0.690914 | 5 | 0 | 5 |
| DSG1 | CERS3 | 0.6898 | 3 | 0 | 3 |
For details and further investigation, click here
