| Full name: acyl-CoA oxidase 1 | Alias Symbol: PALMCOX | ||
| Type: protein-coding gene | Cytoband: 17q25.1 | ||
| Entrez ID: 51 | HGNC ID: HGNC:119 | Ensembl Gene: ENSG00000161533 | OMIM ID: 609751 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
ACOX1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa03320 | PPAR signaling pathway | |
| hsa04024 | cAMP signaling pathway |
Expression of ACOX1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ACOX1 | 51 | 227962_at | -0.2948 | 0.6448 | |
| GSE20347 | ACOX1 | 51 | 209600_s_at | -1.5393 | 0.0000 | |
| GSE23400 | ACOX1 | 51 | 209600_s_at | -1.3265 | 0.0000 | |
| GSE26886 | ACOX1 | 51 | 209600_s_at | -3.0735 | 0.0000 | |
| GSE29001 | ACOX1 | 51 | 209600_s_at | -1.5195 | 0.0036 | |
| GSE38129 | ACOX1 | 51 | 209600_s_at | -1.2296 | 0.0000 | |
| GSE45670 | ACOX1 | 51 | 209600_s_at | -0.4751 | 0.0956 | |
| GSE53622 | ACOX1 | 51 | 60865 | -0.8330 | 0.0000 | |
| GSE53624 | ACOX1 | 51 | 60865 | -0.7053 | 0.0000 | |
| GSE63941 | ACOX1 | 51 | 209600_s_at | -0.3672 | 0.4312 | |
| GSE77861 | ACOX1 | 51 | 209600_s_at | -1.4431 | 0.0016 | |
| GSE97050 | ACOX1 | 51 | A_33_P3244803 | -0.6278 | 0.1619 | |
| SRP007169 | ACOX1 | 51 | RNAseq | -1.9298 | 0.0000 | |
| SRP008496 | ACOX1 | 51 | RNAseq | -2.0432 | 0.0000 | |
| SRP064894 | ACOX1 | 51 | RNAseq | -1.6127 | 0.0000 | |
| SRP133303 | ACOX1 | 51 | RNAseq | -0.7193 | 0.0001 | |
| SRP159526 | ACOX1 | 51 | RNAseq | -1.2947 | 0.0000 | |
| SRP193095 | ACOX1 | 51 | RNAseq | -1.6244 | 0.0000 | |
| SRP219564 | ACOX1 | 51 | RNAseq | -1.5974 | 0.0002 | |
| TCGA | ACOX1 | 51 | RNAseq | -0.3482 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 12.
Survival by ACOX1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ACOX1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ACOX1 | 51 | 7 | 2 | 21 | |
| GSE20123 | ACOX1 | 51 | 7 | 2 | 21 | |
| GSE43470 | ACOX1 | 51 | 5 | 3 | 35 | |
| GSE46452 | ACOX1 | 51 | 34 | 0 | 25 | |
| GSE47630 | ACOX1 | 51 | 8 | 1 | 31 | |
| GSE54993 | ACOX1 | 51 | 2 | 5 | 63 | |
| GSE54994 | ACOX1 | 51 | 10 | 4 | 39 | |
| GSE60625 | ACOX1 | 51 | 6 | 0 | 5 | |
| GSE74703 | ACOX1 | 51 | 5 | 1 | 30 | |
| GSE74704 | ACOX1 | 51 | 5 | 1 | 14 | |
| TCGA | ACOX1 | 51 | 31 | 10 | 55 |
Total number of gains: 120; Total number of losses: 29; Total Number of normals: 339.
Somatic mutations of ACOX1:
Generating mutation plots.
Highly correlated genes for ACOX1:
Showing top 20/1707 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ACOX1 | SORT1 | 0.841236 | 11 | 0 | 11 |
| ACOX1 | SFTA2 | 0.82381 | 3 | 0 | 3 |
| ACOX1 | PCBP1-AS1 | 0.819354 | 3 | 0 | 3 |
| ACOX1 | PSCA | 0.808571 | 7 | 0 | 7 |
| ACOX1 | CGNL1 | 0.805379 | 7 | 0 | 7 |
| ACOX1 | GDPD3 | 0.803454 | 9 | 0 | 9 |
| ACOX1 | ECM1 | 0.800998 | 9 | 0 | 9 |
| ACOX1 | FUT3 | 0.798586 | 9 | 0 | 9 |
| ACOX1 | CLIC3 | 0.794738 | 8 | 0 | 7 |
| ACOX1 | STX12 | 0.794144 | 10 | 0 | 10 |
| ACOX1 | HPGD | 0.792423 | 11 | 0 | 11 |
| ACOX1 | USP54 | 0.791474 | 7 | 0 | 7 |
| ACOX1 | SPAG17 | 0.790295 | 3 | 0 | 3 |
| ACOX1 | RMND5B | 0.787338 | 11 | 0 | 10 |
| ACOX1 | NUCB2 | 0.784123 | 10 | 0 | 10 |
| ACOX1 | FCHO2 | 0.782589 | 6 | 0 | 6 |
| ACOX1 | SLC16A6 | 0.779265 | 10 | 0 | 9 |
| ACOX1 | GYS2 | 0.7785 | 9 | 0 | 9 |
| ACOX1 | RAB11A | 0.778088 | 11 | 0 | 11 |
| ACOX1 | RRAGD | 0.777696 | 10 | 0 | 10 |
For details and further investigation, click here
