| Full name: dystrobrevin binding protein 1 | Alias Symbol: Dysbindin|My031|HPS7|DBND|BLOC1S8 | ||
| Type: protein-coding gene | Cytoband: 6p22.3 | ||
| Entrez ID: 84062 | HGNC ID: HGNC:17328 | Ensembl Gene: ENSG00000047579 | OMIM ID: 607145 |
| Drug and gene relationship at DGIdb | |||
Expression of DTNBP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DTNBP1 | 84062 | 223445_at | 0.4392 | 0.5256 | |
| GSE26886 | DTNBP1 | 84062 | 223445_at | 0.1159 | 0.6716 | |
| GSE45670 | DTNBP1 | 84062 | 223445_at | -0.1345 | 0.4724 | |
| GSE53622 | DTNBP1 | 84062 | 1643 | -0.0049 | 0.9576 | |
| GSE53624 | DTNBP1 | 84062 | 40309 | 0.2101 | 0.0160 | |
| GSE63941 | DTNBP1 | 84062 | 223445_at | -0.4712 | 0.2406 | |
| GSE77861 | DTNBP1 | 84062 | 223445_at | 0.1109 | 0.6984 | |
| GSE97050 | DTNBP1 | 84062 | A_33_P3337242 | 0.0613 | 0.9076 | |
| SRP007169 | DTNBP1 | 84062 | RNAseq | 1.3317 | 0.0714 | |
| SRP064894 | DTNBP1 | 84062 | RNAseq | 0.7297 | 0.0127 | |
| SRP133303 | DTNBP1 | 84062 | RNAseq | 0.0778 | 0.6723 | |
| SRP159526 | DTNBP1 | 84062 | RNAseq | 0.3465 | 0.1632 | |
| SRP193095 | DTNBP1 | 84062 | RNAseq | 0.3534 | 0.0340 | |
| SRP219564 | DTNBP1 | 84062 | RNAseq | 0.0381 | 0.9453 | |
| TCGA | DTNBP1 | 84062 | RNAseq | -0.2228 | 0.0014 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DTNBP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DTNBP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DTNBP1 | 84062 | 3 | 6 | 21 | |
| GSE20123 | DTNBP1 | 84062 | 3 | 6 | 21 | |
| GSE43470 | DTNBP1 | 84062 | 9 | 0 | 34 | |
| GSE46452 | DTNBP1 | 84062 | 1 | 10 | 48 | |
| GSE47630 | DTNBP1 | 84062 | 7 | 7 | 26 | |
| GSE54993 | DTNBP1 | 84062 | 1 | 1 | 68 | |
| GSE54994 | DTNBP1 | 84062 | 10 | 3 | 40 | |
| GSE60625 | DTNBP1 | 84062 | 0 | 1 | 10 | |
| GSE74703 | DTNBP1 | 84062 | 8 | 0 | 28 | |
| GSE74704 | DTNBP1 | 84062 | 2 | 2 | 16 | |
| TCGA | DTNBP1 | 84062 | 16 | 27 | 53 |
Total number of gains: 60; Total number of losses: 63; Total Number of normals: 365.
Somatic mutations of DTNBP1:
Generating mutation plots.
Highly correlated genes for DTNBP1:
Showing top 20/302 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DTNBP1 | TESK1 | 0.773156 | 3 | 0 | 3 |
| DTNBP1 | TBPL1 | 0.747711 | 3 | 0 | 3 |
| DTNBP1 | PELI2 | 0.735322 | 3 | 0 | 3 |
| DTNBP1 | GCDH | 0.731377 | 4 | 0 | 4 |
| DTNBP1 | LSM14A | 0.730915 | 3 | 0 | 3 |
| DTNBP1 | CCDC124 | 0.724352 | 3 | 0 | 3 |
| DTNBP1 | ECSIT | 0.716819 | 4 | 0 | 4 |
| DTNBP1 | CYHR1 | 0.711434 | 3 | 0 | 3 |
| DTNBP1 | ZNF628 | 0.708324 | 3 | 0 | 3 |
| DTNBP1 | ULK1 | 0.707255 | 3 | 0 | 3 |
| DTNBP1 | CDIPT | 0.70677 | 3 | 0 | 3 |
| DTNBP1 | LCMT1 | 0.700083 | 3 | 0 | 3 |
| DTNBP1 | VGLL4 | 0.699673 | 3 | 0 | 3 |
| DTNBP1 | ORMDL3 | 0.689162 | 4 | 0 | 4 |
| DTNBP1 | B4GALT2 | 0.687455 | 3 | 0 | 3 |
| DTNBP1 | RING1 | 0.686128 | 4 | 0 | 3 |
| DTNBP1 | CCDC93 | 0.6851 | 3 | 0 | 3 |
| DTNBP1 | INSR | 0.684997 | 4 | 0 | 4 |
| DTNBP1 | PRDM15 | 0.682921 | 3 | 0 | 3 |
| DTNBP1 | ZNF627 | 0.67938 | 3 | 0 | 3 |
For details and further investigation, click here
