INSR

 

Full name: insulin receptor Alias Symbol: CD220
Type: protein-coding gene Cytoband: 19p13.2
Entrez ID: 3643 HGNC ID: HGNC:6091 Ensembl Gene: ENSG00000171105 OMIM ID: 147670
Drug and gene relationship at DGIdb

 

INSR involved pathways:

KEGG pathway Description View
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04066HIF-1 signaling pathway
hsa04068FoxO signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04150mTOR signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04152AMPK signaling pathway
hsa04211Longevity regulating pathway - mammal
hsa04213Longevity regulating pathway - multiple species
hsa04910Insulin signaling pathway
hsa04913Ovarian steroidogenesis
hsa04923Regulation of lipolysis in adipocytes
hsa04930Type II diabetes mellitus
hsa04931Insulin resistance
hsa04932Non-alcoholic fatty liver disease (NAFLD)
hsa04960Aldosterone-regulated sodium reabsorption

 

Expression of INSR:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 INSR 3643 213792_s_at 0.3821 0.3119
GSE20347 INSR 3643 213792_s_at 0.6934 0.0002
GSE23400 INSR 3643 213792_s_at 0.3744 0.0001
GSE26886 INSR 3643 213792_s_at 1.0145 0.0026
GSE29001 INSR 3643 213792_s_at 0.6263 0.2326
GSE38129 INSR 3643 213792_s_at 0.4265 0.1659
GSE45670 INSR 3643 213792_s_at 0.2777 0.2300
GSE53622 INSR 3643 84756 0.3190 0.0089
GSE53624 INSR 3643 84756 0.4533 0.0000
GSE63941 INSR 3643 213792_s_at -0.2389 0.6176
GSE77861 INSR 3643 226450_at 0.3796 0.0029
GSE97050 INSR 3643 A_33_P3335725 -0.1578 0.5789
SRP007169 INSR 3643 RNAseq 2.5913 0.0000
SRP008496 INSR 3643 RNAseq 2.1515 0.0000
SRP064894 INSR 3643 RNAseq 0.9867 0.0000
SRP133303 INSR 3643 RNAseq 0.5130 0.0097
SRP159526 INSR 3643 RNAseq 0.8350 0.0036
SRP193095 INSR 3643 RNAseq 0.2671 0.2683
SRP219564 INSR 3643 RNAseq 0.7377 0.1459
TCGA INSR 3643 RNAseq -0.3643 0.0000

Upregulated datasets: 3; Downregulated datasets: 0.  

 

Survival by INSR expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of INSR:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 INSR 3643 5 3 22
GSE20123 INSR 3643 4 2 24
GSE43470 INSR 3643 2 6 35
GSE46452 INSR 3643 47 1 11
GSE47630 INSR 3643 5 7 28
GSE54993 INSR 3643 16 3 51
GSE54994 INSR 3643 8 15 30
GSE60625 INSR 3643 9 0 2
GSE74703 INSR 3643 2 4 30
GSE74704 INSR 3643 1 2 17
TCGA INSR 3643 8 21 67

Total number of gains: 107; Total number of losses: 64; Total Number of normals: 317.  

 

Somatic mutations of INSR:

 

Generating mutation plots.

 

Highly correlated genes for INSR:

 

Showing top 20/1374 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
INSRWDR50.772819303
INSRCCDC1270.759404303
INSRBRPF30.742786303
INSRLINC006740.74008303
INSRDNM1L0.736399403
INSRMARK10.727311303
INSRPPP1R350.726249303
INSREFTUD20.726037303
INSRCCT50.720875303
INSRKCNE30.719431303
INSRXXYLT10.715276303
INSROAZ20.713513303
INSRFILIP10.71076303
INSRSSBP40.709754504
INSRMSI20.709432303
INSRSNRPG0.70564404
INSRWDR250.705623303
INSRUSP360.705595303
INSREBF10.698973303
INSRTHEM40.698473303

For details and further investigation, click here