| Full name: deltex E3 ubiquitin ligase 2 | Alias Symbol: RNF58|KIAA1528 | ||
| Type: protein-coding gene | Cytoband: 7q11.23 | ||
| Entrez ID: 113878 | HGNC ID: HGNC:15973 | Ensembl Gene: ENSG00000091073 | OMIM ID: 613141 |
| Drug and gene relationship at DGIdb | |||
DTX2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04330 | Notch signaling pathway |
Expression of DTX2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DTX2 | 113878 | 215732_s_at | 0.4122 | 0.5314 | |
| GSE20347 | DTX2 | 113878 | 215732_s_at | -0.7145 | 0.0001 | |
| GSE23400 | DTX2 | 113878 | 215732_s_at | -0.9016 | 0.0000 | |
| GSE26886 | DTX2 | 113878 | 215732_s_at | -0.5540 | 0.0558 | |
| GSE29001 | DTX2 | 113878 | 215732_s_at | -0.9072 | 0.0065 | |
| GSE38129 | DTX2 | 113878 | 215732_s_at | -0.5547 | 0.0045 | |
| GSE45670 | DTX2 | 113878 | 215732_s_at | -0.0984 | 0.6193 | |
| GSE53622 | DTX2 | 113878 | 29231 | -0.9016 | 0.0000 | |
| GSE53624 | DTX2 | 113878 | 29231 | -1.1400 | 0.0000 | |
| GSE63941 | DTX2 | 113878 | 215732_s_at | 0.6705 | 0.0625 | |
| GSE77861 | DTX2 | 113878 | 215732_s_at | -0.4643 | 0.0046 | |
| GSE97050 | DTX2 | A_21_P0013245 | -0.0328 | 0.9216 | ||
| SRP007169 | DTX2 | 113878 | RNAseq | -3.2047 | 0.0000 | |
| SRP008496 | DTX2 | 113878 | RNAseq | -3.0093 | 0.0000 | |
| SRP064894 | DTX2 | 113878 | RNAseq | -1.5260 | 0.0000 | |
| SRP133303 | DTX2 | 113878 | RNAseq | -0.6384 | 0.0051 | |
| SRP159526 | DTX2 | 113878 | RNAseq | -1.4483 | 0.0000 | |
| SRP193095 | DTX2 | 113878 | RNAseq | -0.7038 | 0.0047 | |
| SRP219564 | DTX2 | 113878 | RNAseq | -0.7745 | 0.1637 | |
| TCGA | DTX2 | 113878 | RNAseq | 0.2804 | 0.0002 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by DTX2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DTX2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DTX2 | 113878 | 15 | 1 | 14 | |
| GSE20123 | DTX2 | 113878 | 15 | 1 | 14 | |
| GSE43470 | DTX2 | 113878 | 3 | 2 | 38 | |
| GSE46452 | DTX2 | 113878 | 11 | 0 | 48 | |
| GSE47630 | DTX2 | 113878 | 7 | 3 | 30 | |
| GSE54993 | DTX2 | 113878 | 2 | 7 | 61 | |
| GSE54994 | DTX2 | 113878 | 15 | 3 | 35 | |
| GSE60625 | DTX2 | 113878 | 0 | 0 | 11 | |
| GSE74703 | DTX2 | 113878 | 3 | 1 | 32 | |
| GSE74704 | DTX2 | 113878 | 8 | 1 | 11 | |
| TCGA | DTX2 | 113878 | 44 | 5 | 47 |
Total number of gains: 123; Total number of losses: 24; Total Number of normals: 341.
Somatic mutations of DTX2:
Generating mutation plots.
Highly correlated genes for DTX2:
Showing top 20/1013 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DTX2 | UPK3B | 0.830448 | 3 | 0 | 3 |
| DTX2 | LRRC29 | 0.749194 | 3 | 0 | 3 |
| DTX2 | SCNN1B | 0.733721 | 10 | 0 | 10 |
| DTX2 | PGLYRP3 | 0.731108 | 3 | 0 | 3 |
| DTX2 | GYS2 | 0.725489 | 9 | 0 | 9 |
| DTX2 | LTA4H | 0.722013 | 3 | 0 | 3 |
| DTX2 | EVPL | 0.70113 | 12 | 0 | 10 |
| DTX2 | RARG | 0.698774 | 10 | 0 | 8 |
| DTX2 | ARHGAP40 | 0.697554 | 3 | 0 | 3 |
| DTX2 | PITX1 | 0.696226 | 11 | 0 | 10 |
| DTX2 | TTC9 | 0.695684 | 10 | 0 | 9 |
| DTX2 | CPTP | 0.692558 | 8 | 0 | 7 |
| DTX2 | SPRR2D | 0.690103 | 3 | 0 | 3 |
| DTX2 | RANBP9 | 0.689763 | 9 | 0 | 8 |
| DTX2 | MXD1 | 0.688405 | 10 | 0 | 8 |
| DTX2 | SNX24 | 0.688373 | 10 | 0 | 9 |
| DTX2 | SDCBP2 | 0.688304 | 3 | 0 | 3 |
| DTX2 | IL12A-AS1 | 0.687989 | 5 | 0 | 5 |
| DTX2 | TSC22D4 | 0.686027 | 7 | 0 | 7 |
| DTX2 | IL36A | 0.684083 | 10 | 0 | 9 |
For details and further investigation, click here
