| Full name: SP140 nuclear body protein | Alias Symbol: LYSP100-B|LYSP100-A | ||
| Type: protein-coding gene | Cytoband: 2q37.1 | ||
| Entrez ID: 11262 | HGNC ID: HGNC:17133 | Ensembl Gene: ENSG00000079263 | OMIM ID: 608602 |
| Drug and gene relationship at DGIdb | |||
Expression of SP140:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | SP140 | 11262 | 1416 | 0.6901 | 0.0000 | |
| GSE53624 | SP140 | 11262 | 100807 | 0.6851 | 0.0000 | |
| GSE97050 | SP140 | 11262 | A_23_P209726 | 1.0708 | 0.1678 | |
| SRP064894 | SP140 | 11262 | RNAseq | 0.9018 | 0.0030 | |
| SRP133303 | SP140 | 11262 | RNAseq | -0.0409 | 0.9015 | |
| SRP159526 | SP140 | 11262 | RNAseq | -0.8359 | 0.3827 | |
| SRP193095 | SP140 | 11262 | RNAseq | 0.0513 | 0.8524 | |
| SRP219564 | SP140 | 11262 | RNAseq | 1.5155 | 0.0056 | |
| TCGA | SP140 | 11262 | RNAseq | 0.1172 | 0.6900 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by SP140 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SP140:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SP140 | 11262 | 1 | 13 | 16 | |
| GSE20123 | SP140 | 11262 | 1 | 13 | 16 | |
| GSE43470 | SP140 | 11262 | 2 | 8 | 33 | |
| GSE46452 | SP140 | 11262 | 0 | 5 | 54 | |
| GSE47630 | SP140 | 11262 | 4 | 5 | 31 | |
| GSE54993 | SP140 | 11262 | 2 | 2 | 66 | |
| GSE54994 | SP140 | 11262 | 6 | 11 | 36 | |
| GSE60625 | SP140 | 11262 | 0 | 3 | 8 | |
| GSE74703 | SP140 | 11262 | 2 | 6 | 28 | |
| GSE74704 | SP140 | 11262 | 1 | 6 | 13 | |
| TCGA | SP140 | 11262 | 13 | 27 | 56 |
Total number of gains: 32; Total number of losses: 99; Total Number of normals: 357.
Somatic mutations of SP140:
Generating mutation plots.
Highly correlated genes for SP140:
Showing top 20/46 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SP140 | SP140L | 0.860967 | 3 | 0 | 3 |
| SP140 | TMEM106A | 0.734235 | 3 | 0 | 3 |
| SP140 | PARP12 | 0.7248 | 3 | 0 | 3 |
| SP140 | DTX3L | 0.723348 | 3 | 0 | 3 |
| SP140 | CXCL13 | 0.719032 | 3 | 0 | 3 |
| SP140 | PARVG | 0.716785 | 3 | 0 | 3 |
| SP140 | IL18BP | 0.709372 | 3 | 0 | 3 |
| SP140 | MOV10 | 0.696024 | 3 | 0 | 3 |
| SP140 | LIMK1 | 0.689465 | 3 | 0 | 3 |
| SP140 | APOL2 | 0.678186 | 3 | 0 | 3 |
| SP140 | AGRN | 0.677786 | 3 | 0 | 3 |
| SP140 | KIAA0930 | 0.674271 | 3 | 0 | 3 |
| SP140 | OSBPL3 | 0.671241 | 3 | 0 | 3 |
| SP140 | DNMT1 | 0.669459 | 3 | 0 | 3 |
| SP140 | XAF1 | 0.668478 | 4 | 0 | 3 |
| SP140 | VAC14 | 0.663171 | 3 | 0 | 3 |
| SP140 | CMIP | 0.663003 | 3 | 0 | 3 |
| SP140 | STAT1 | 0.66298 | 4 | 0 | 3 |
| SP140 | PYHIN1 | 0.653504 | 4 | 0 | 3 |
| SP140 | ZNFX1 | 0.652773 | 3 | 0 | 3 |
For details and further investigation, click here
