| Full name: calreticulin | Alias Symbol: RO|SSA|cC1qR|CRT|FLJ26680 | ||
| Type: protein-coding gene | Cytoband: 19p13.13 | ||
| Entrez ID: 811 | HGNC ID: HGNC:1455 | Ensembl Gene: ENSG00000179218 | OMIM ID: 109091 |
| Drug and gene relationship at DGIdb | |||
CALR involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05142 | Chagas disease (American trypanosomiasis) | |
| hsa05166 | HTLV-I infection |
Expression of CALR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CALR | 811 | 212953_x_at | 0.4593 | 0.3634 | |
| GSE20347 | CALR | 811 | 212953_x_at | -0.0280 | 0.7926 | |
| GSE23400 | CALR | 811 | 212953_x_at | 0.2231 | 0.0020 | |
| GSE29001 | CALR | 811 | 212953_x_at | -0.0148 | 0.9593 | |
| GSE38129 | CALR | 811 | 212953_x_at | 0.1573 | 0.1059 | |
| GSE45670 | CALR | 811 | 212953_x_at | 0.3890 | 0.0000 | |
| GSE77861 | CALR | 811 | 212953_x_at | -0.0461 | 0.8209 | |
| GSE97050 | CALR | 811 | A_33_P3292854 | 0.6802 | 0.1623 | |
| SRP007169 | CALR | 811 | RNAseq | -0.4060 | 0.2699 | |
| SRP008496 | CALR | 811 | RNAseq | -0.2862 | 0.1759 | |
| SRP064894 | CALR | 811 | RNAseq | 0.7665 | 0.0002 | |
| SRP133303 | CALR | 811 | RNAseq | 0.5983 | 0.0003 | |
| SRP159526 | CALR | 811 | RNAseq | 0.6378 | 0.0204 | |
| SRP193095 | CALR | 811 | RNAseq | 0.1353 | 0.3263 | |
| SRP219564 | CALR | 811 | RNAseq | 0.9608 | 0.0157 | |
| TCGA | CALR | 811 | RNAseq | 0.1095 | 0.0029 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CALR expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of CALR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CALR | 811 | 4 | 2 | 24 | |
| GSE20123 | CALR | 811 | 3 | 1 | 26 | |
| GSE43470 | CALR | 811 | 2 | 6 | 35 | |
| GSE46452 | CALR | 811 | 47 | 1 | 11 | |
| GSE47630 | CALR | 811 | 4 | 7 | 29 | |
| GSE54993 | CALR | 811 | 16 | 3 | 51 | |
| GSE54994 | CALR | 811 | 8 | 13 | 32 | |
| GSE60625 | CALR | 811 | 9 | 0 | 2 | |
| GSE74703 | CALR | 811 | 2 | 4 | 30 | |
| GSE74704 | CALR | 811 | 0 | 1 | 19 | |
| TCGA | CALR | 811 | 17 | 12 | 67 |
Total number of gains: 112; Total number of losses: 50; Total Number of normals: 326.
Somatic mutations of CALR:
Generating mutation plots.
Highly correlated genes for CALR:
Showing top 20/292 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CALR | SHKBP1 | 0.794878 | 3 | 0 | 3 |
| CALR | DTX3L | 0.727322 | 3 | 0 | 3 |
| CALR | RASAL3 | 0.718783 | 3 | 0 | 3 |
| CALR | RAB3IP | 0.696113 | 3 | 0 | 3 |
| CALR | PRKCSH | 0.691043 | 5 | 0 | 5 |
| CALR | TYK2 | 0.690609 | 4 | 0 | 4 |
| CALR | CDK18 | 0.684971 | 4 | 0 | 4 |
| CALR | KHSRP | 0.682553 | 4 | 0 | 4 |
| CALR | ARHGDIA | 0.679232 | 5 | 0 | 4 |
| CALR | HAPLN3 | 0.678938 | 3 | 0 | 3 |
| CALR | ATAD3B | 0.675547 | 4 | 0 | 4 |
| CALR | B4GALT7 | 0.672511 | 3 | 0 | 3 |
| CALR | ATAD3A | 0.669583 | 4 | 0 | 3 |
| CALR | RCC2 | 0.666912 | 3 | 0 | 3 |
| CALR | UBE2J2 | 0.661611 | 3 | 0 | 3 |
| CALR | ZC3H3 | 0.656011 | 4 | 0 | 3 |
| CALR | PAK1IP1 | 0.653784 | 3 | 0 | 3 |
| CALR | HSPBP1 | 0.651493 | 4 | 0 | 4 |
| CALR | TDG | 0.650335 | 3 | 0 | 3 |
| CALR | DNAJB11 | 0.648346 | 3 | 0 | 3 |
For details and further investigation, click here
