UMPS

 

Full name: uridine monophosphate synthetase Alias Symbol: 
Type: protein-coding gene Cytoband: 3q21.2
Entrez ID: 7372 HGNC ID: HGNC:12563 Ensembl Gene: ENSG00000114491 OMIM ID: 613891
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of UMPS:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 UMPS 7372 215165_x_at 0.9759 0.0508
GSE20347 UMPS 7372 215165_x_at 0.9193 0.0000
GSE23400 UMPS 7372 202706_s_at 0.8337 0.0000
GSE26886 UMPS 7372 215165_x_at 0.2673 0.1203
GSE29001 UMPS 7372 215165_x_at 0.9395 0.0069
GSE38129 UMPS 7372 215165_x_at 1.0186 0.0000
GSE45670 UMPS 7372 215165_x_at 0.9178 0.0000
GSE53622 UMPS 7372 21533 0.6931 0.0000
GSE53624 UMPS 7372 21533 0.9580 0.0000
GSE63941 UMPS 7372 215165_x_at 0.9453 0.0152
GSE77861 UMPS 7372 202706_s_at 0.5780 0.1127
GSE97050 UMPS 7372 A_23_P6624 0.5744 0.1861
SRP007169 UMPS 7372 RNAseq 1.3989 0.0014
SRP008496 UMPS 7372 RNAseq 1.3177 0.0001
SRP064894 UMPS 7372 RNAseq 0.6511 0.0072
SRP133303 UMPS 7372 RNAseq 0.5375 0.0064
SRP159526 UMPS 7372 RNAseq 0.8261 0.0223
SRP193095 UMPS 7372 RNAseq 0.4554 0.0001
SRP219564 UMPS 7372 RNAseq 0.3709 0.3129
TCGA UMPS 7372 RNAseq 0.2742 0.0000

Upregulated datasets: 3; Downregulated datasets: 0.  

 

Survival by UMPS expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of UMPS:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 UMPS 7372 17 0 13
GSE20123 UMPS 7372 17 0 13
GSE43470 UMPS 7372 20 0 23
GSE46452 UMPS 7372 14 5 40
GSE47630 UMPS 7372 17 4 19
GSE54993 UMPS 7372 2 7 61
GSE54994 UMPS 7372 31 3 19
GSE60625 UMPS 7372 0 6 5
GSE74703 UMPS 7372 17 0 19
GSE74704 UMPS 7372 13 0 7
TCGA UMPS 7372 55 6 35

Total number of gains: 203; Total number of losses: 31; Total Number of normals: 254.  

 

Somatic mutations of UMPS:

 

Generating mutation plots.

 

Highly correlated genes for UMPS:

 

Showing top 20/1832 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
UMPSMRPL30.84283111011
UMPSRUVBL10.81978712012
UMPSALG10.815732404
UMPSMCM20.7917510010
UMPSCENPN0.7897911011
UMPSTOPBP10.78465911011
UMPSSLC25A390.780132303
UMPSFBXO450.780116303
UMPSGMPS0.77875611011
UMPSCDCA20.777654404
UMPSUBE2C0.7758211009
UMPSTPX20.77508710010
UMPSDTX40.773187303
UMPSLRRC580.771664505
UMPSCDKN30.76985110010
UMPSUCK20.769753303
UMPSANLN0.762214505
UMPSDKC10.752482303
UMPSGEN10.751819505
UMPSHMCES0.74943310010

For details and further investigation, click here