| Full name: dual specificity phosphatase 8 | Alias Symbol: HVH-5|HB5|FLJ42958 | ||
| Type: protein-coding gene | Cytoband: 11p15.5 | ||
| Entrez ID: 1850 | HGNC ID: HGNC:3074 | Ensembl Gene: ENSG00000184545 | OMIM ID: 602038 |
| Drug and gene relationship at DGIdb | |||
DUSP8 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway |
Expression of DUSP8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | DUSP8 | 1850 | 44805 | -0.3394 | 0.0003 | |
| GSE53624 | DUSP8 | 1850 | 44805 | -0.7096 | 0.0000 | |
| GSE97050 | DUSP8 | 1850 | A_32_P98298 | -0.3736 | 0.4541 | |
| SRP007169 | DUSP8 | 1850 | RNAseq | 1.3797 | 0.0747 | |
| SRP064894 | DUSP8 | 1850 | RNAseq | -0.0062 | 0.9766 | |
| SRP133303 | DUSP8 | 1850 | RNAseq | -0.0919 | 0.6751 | |
| SRP159526 | DUSP8 | 1850 | RNAseq | 0.0337 | 0.9133 | |
| SRP193095 | DUSP8 | 1850 | RNAseq | 0.3828 | 0.0496 | |
| SRP219564 | DUSP8 | 1850 | RNAseq | -0.3824 | 0.4845 | |
| TCGA | DUSP8 | 1850 | RNAseq | -0.3515 | 0.0029 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DUSP8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DUSP8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DUSP8 | 1850 | 1 | 11 | 18 | |
| GSE20123 | DUSP8 | 1850 | 1 | 12 | 17 | |
| GSE43470 | DUSP8 | 1850 | 1 | 9 | 33 | |
| GSE46452 | DUSP8 | 1850 | 7 | 8 | 44 | |
| GSE47630 | DUSP8 | 1850 | 4 | 12 | 24 | |
| GSE54993 | DUSP8 | 1850 | 3 | 1 | 66 | |
| GSE54994 | DUSP8 | 1850 | 1 | 12 | 40 | |
| GSE60625 | DUSP8 | 1850 | 0 | 0 | 11 | |
| GSE74703 | DUSP8 | 1850 | 1 | 7 | 28 | |
| GSE74704 | DUSP8 | 1850 | 0 | 8 | 12 | |
| TCGA | DUSP8 | 1850 | 8 | 39 | 49 |
Total number of gains: 27; Total number of losses: 119; Total Number of normals: 342.
Somatic mutations of DUSP8:
Generating mutation plots.
Highly correlated genes for DUSP8:
Showing top 20/43 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DUSP8 | VMAC | 0.749253 | 3 | 0 | 3 |
| DUSP8 | IFFO1 | 0.747524 | 3 | 0 | 3 |
| DUSP8 | THRA | 0.708415 | 3 | 0 | 3 |
| DUSP8 | PLP1 | 0.70506 | 3 | 0 | 3 |
| DUSP8 | SOX17 | 0.697598 | 3 | 0 | 3 |
| DUSP8 | IMPDH1 | 0.693122 | 3 | 0 | 3 |
| DUSP8 | C16orf86 | 0.683457 | 3 | 0 | 3 |
| DUSP8 | SCRG1 | 0.682572 | 3 | 0 | 3 |
| DUSP8 | SLC35F1 | 0.666015 | 3 | 0 | 3 |
| DUSP8 | ADCYAP1R1 | 0.662638 | 3 | 0 | 3 |
| DUSP8 | DOCK3 | 0.659531 | 3 | 0 | 3 |
| DUSP8 | ANKS1B | 0.652158 | 3 | 0 | 3 |
| DUSP8 | MOG | 0.651643 | 3 | 0 | 3 |
| DUSP8 | NUMBL | 0.642604 | 3 | 0 | 3 |
| DUSP8 | TMEM174 | 0.641473 | 3 | 0 | 3 |
| DUSP8 | C8orf58 | 0.637311 | 3 | 0 | 3 |
| DUSP8 | ZNF154 | 0.635964 | 3 | 0 | 3 |
| DUSP8 | ZNF577 | 0.630537 | 3 | 0 | 3 |
| DUSP8 | CCDC88C | 0.630298 | 3 | 0 | 3 |
| DUSP8 | LHX3 | 0.628326 | 3 | 0 | 3 |
For details and further investigation, click here
