| Full name: dedicator of cytokinesis 3 | Alias Symbol: KIAA0299|MOCA|PBP | ||
| Type: protein-coding gene | Cytoband: 3p21.2 | ||
| Entrez ID: 1795 | HGNC ID: HGNC:2989 | Ensembl Gene: ENSG00000088538 | OMIM ID: 603123 |
| Drug and gene relationship at DGIdb | |||
Expression of DOCK3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DOCK3 | 1795 | 213482_at | -1.3968 | 0.0711 | |
| GSE20347 | DOCK3 | 1795 | 213482_at | -0.3409 | 0.0000 | |
| GSE23400 | DOCK3 | 1795 | 213482_at | -0.4903 | 0.0000 | |
| GSE26886 | DOCK3 | 1795 | 213482_at | -1.0602 | 0.0002 | |
| GSE29001 | DOCK3 | 1795 | 213482_at | -0.8496 | 0.1292 | |
| GSE38129 | DOCK3 | 1795 | 213482_at | -0.6742 | 0.0001 | |
| GSE45670 | DOCK3 | 1795 | 213482_at | -0.8719 | 0.0085 | |
| GSE53622 | DOCK3 | 1795 | 15076 | -0.8928 | 0.0000 | |
| GSE53624 | DOCK3 | 1795 | 15076 | -0.4385 | 0.0000 | |
| GSE63941 | DOCK3 | 1795 | 213482_at | 0.3437 | 0.6014 | |
| GSE77861 | DOCK3 | 1795 | 213482_at | -0.2028 | 0.2353 | |
| GSE97050 | DOCK3 | 1795 | A_24_P272845 | -0.8786 | 0.2500 | |
| SRP007169 | DOCK3 | 1795 | RNAseq | -1.5682 | 0.1061 | |
| SRP008496 | DOCK3 | 1795 | RNAseq | -2.1367 | 0.0290 | |
| SRP064894 | DOCK3 | 1795 | RNAseq | -2.3093 | 0.0000 | |
| SRP133303 | DOCK3 | 1795 | RNAseq | -1.5090 | 0.0011 | |
| SRP159526 | DOCK3 | 1795 | RNAseq | -0.6674 | 0.2460 | |
| SRP193095 | DOCK3 | 1795 | RNAseq | -1.8665 | 0.0000 | |
| SRP219564 | DOCK3 | 1795 | RNAseq | -1.6353 | 0.0754 | |
| TCGA | DOCK3 | 1795 | RNAseq | -0.8041 | 0.0079 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by DOCK3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DOCK3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DOCK3 | 1795 | 1 | 17 | 12 | |
| GSE20123 | DOCK3 | 1795 | 0 | 19 | 11 | |
| GSE43470 | DOCK3 | 1795 | 0 | 18 | 25 | |
| GSE46452 | DOCK3 | 1795 | 2 | 16 | 41 | |
| GSE47630 | DOCK3 | 1795 | 1 | 24 | 15 | |
| GSE54993 | DOCK3 | 1795 | 6 | 2 | 62 | |
| GSE54994 | DOCK3 | 1795 | 0 | 34 | 19 | |
| GSE60625 | DOCK3 | 1795 | 5 | 0 | 6 | |
| GSE74703 | DOCK3 | 1795 | 0 | 14 | 22 | |
| GSE74704 | DOCK3 | 1795 | 0 | 12 | 8 | |
| TCGA | DOCK3 | 1795 | 0 | 78 | 18 |
Total number of gains: 15; Total number of losses: 234; Total Number of normals: 239.
Somatic mutations of DOCK3:
Generating mutation plots.
Highly correlated genes for DOCK3:
Showing top 20/1050 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DOCK3 | RGS7BP | 0.766937 | 3 | 0 | 3 |
| DOCK3 | SORCS1 | 0.764389 | 3 | 0 | 3 |
| DOCK3 | ZNRF1 | 0.751797 | 3 | 0 | 3 |
| DOCK3 | ZNF57 | 0.751241 | 3 | 0 | 3 |
| DOCK3 | GABRA5 | 0.743601 | 5 | 0 | 5 |
| DOCK3 | FBXO30 | 0.743329 | 3 | 0 | 3 |
| DOCK3 | FAM219B | 0.738452 | 3 | 0 | 3 |
| DOCK3 | VMAC | 0.733682 | 3 | 0 | 3 |
| DOCK3 | NEGR1 | 0.717865 | 4 | 0 | 3 |
| DOCK3 | MTUS2 | 0.713085 | 5 | 0 | 5 |
| DOCK3 | ARHGAP27 | 0.70578 | 4 | 0 | 3 |
| DOCK3 | ARHGAP10 | 0.70515 | 11 | 0 | 10 |
| DOCK3 | FRMD3 | 0.704312 | 3 | 0 | 3 |
| DOCK3 | ZMAT4 | 0.70345 | 3 | 0 | 3 |
| DOCK3 | STX8 | 0.701481 | 3 | 0 | 3 |
| DOCK3 | LDB3 | 0.697247 | 6 | 0 | 6 |
| DOCK3 | BTC | 0.694238 | 10 | 0 | 9 |
| DOCK3 | ASB5 | 0.68758 | 4 | 0 | 3 |
| DOCK3 | SH3BGR | 0.686242 | 6 | 0 | 5 |
| DOCK3 | KLB | 0.685451 | 3 | 0 | 3 |
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