| Full name: dynein light chain Tctex-type 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 6q25.3 | ||
| Entrez ID: 6993 | HGNC ID: HGNC:11697 | Ensembl Gene: ENSG00000146425 | OMIM ID: 601554 |
| Drug and gene relationship at DGIdb | |||
Expression of DYNLT1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DYNLT1 | 6993 | 201999_s_at | -0.1405 | 0.7396 | |
| GSE20347 | DYNLT1 | 6993 | 201999_s_at | -0.6723 | 0.0000 | |
| GSE23400 | DYNLT1 | 6993 | 201999_s_at | -0.3243 | 0.0000 | |
| GSE26886 | DYNLT1 | 6993 | 201999_s_at | -0.2764 | 0.1121 | |
| GSE29001 | DYNLT1 | 6993 | 201999_s_at | -0.4125 | 0.0348 | |
| GSE38129 | DYNLT1 | 6993 | 201999_s_at | -0.3387 | 0.0158 | |
| GSE45670 | DYNLT1 | 6993 | 201999_s_at | -0.2727 | 0.0155 | |
| GSE53622 | DYNLT1 | 6993 | 89723 | -0.5283 | 0.0000 | |
| GSE53624 | DYNLT1 | 6993 | 89723 | -0.4223 | 0.0000 | |
| GSE63941 | DYNLT1 | 6993 | 201999_s_at | -0.9007 | 0.0234 | |
| GSE77861 | DYNLT1 | 6993 | 201999_s_at | -0.3904 | 0.1254 | |
| GSE97050 | DYNLT1 | 6993 | A_23_P8185 | -0.2392 | 0.4724 | |
| SRP007169 | DYNLT1 | 6993 | RNAseq | -1.5876 | 0.0000 | |
| SRP008496 | DYNLT1 | 6993 | RNAseq | -1.4821 | 0.0000 | |
| SRP064894 | DYNLT1 | 6993 | RNAseq | -0.5090 | 0.0052 | |
| SRP133303 | DYNLT1 | 6993 | RNAseq | -0.3081 | 0.0238 | |
| SRP159526 | DYNLT1 | 6993 | RNAseq | -0.7718 | 0.0003 | |
| SRP193095 | DYNLT1 | 6993 | RNAseq | -0.9795 | 0.0000 | |
| SRP219564 | DYNLT1 | 6993 | RNAseq | -0.7641 | 0.0026 | |
| TCGA | DYNLT1 | 6993 | RNAseq | 0.0761 | 0.1555 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by DYNLT1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DYNLT1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DYNLT1 | 6993 | 3 | 5 | 22 | |
| GSE20123 | DYNLT1 | 6993 | 3 | 4 | 23 | |
| GSE43470 | DYNLT1 | 6993 | 4 | 0 | 39 | |
| GSE46452 | DYNLT1 | 6993 | 3 | 10 | 46 | |
| GSE47630 | DYNLT1 | 6993 | 9 | 4 | 27 | |
| GSE54993 | DYNLT1 | 6993 | 3 | 2 | 65 | |
| GSE54994 | DYNLT1 | 6993 | 8 | 8 | 37 | |
| GSE60625 | DYNLT1 | 6993 | 0 | 1 | 10 | |
| GSE74703 | DYNLT1 | 6993 | 4 | 0 | 32 | |
| GSE74704 | DYNLT1 | 6993 | 1 | 2 | 17 | |
| TCGA | DYNLT1 | 6993 | 13 | 22 | 61 |
Total number of gains: 51; Total number of losses: 58; Total Number of normals: 379.
Somatic mutations of DYNLT1:
Generating mutation plots.
Highly correlated genes for DYNLT1:
Showing top 20/936 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DYNLT1 | RSPH3 | 0.727959 | 4 | 0 | 4 |
| DYNLT1 | TRIM56 | 0.692419 | 3 | 0 | 3 |
| DYNLT1 | HEBP2 | 0.662926 | 13 | 0 | 11 |
| DYNLT1 | STK39 | 0.661063 | 12 | 0 | 11 |
| DYNLT1 | PWWP2B | 0.655288 | 5 | 0 | 4 |
| DYNLT1 | TBC1D22B | 0.648542 | 4 | 0 | 3 |
| DYNLT1 | SLC30A9 | 0.644013 | 10 | 0 | 9 |
| DYNLT1 | DCAF10 | 0.64247 | 7 | 0 | 6 |
| DYNLT1 | UBC | 0.638004 | 3 | 0 | 3 |
| DYNLT1 | SNX3 | 0.63723 | 12 | 0 | 10 |
| DYNLT1 | MPC1 | 0.63497 | 11 | 0 | 10 |
| DYNLT1 | VDAC2 | 0.632986 | 9 | 0 | 8 |
| DYNLT1 | GMPPB | 0.631695 | 3 | 0 | 3 |
| DYNLT1 | TMEM120A | 0.630342 | 6 | 0 | 5 |
| DYNLT1 | CNN3 | 0.628645 | 9 | 0 | 8 |
| DYNLT1 | PSMD7 | 0.626056 | 3 | 0 | 3 |
| DYNLT1 | LINC00929 | 0.625774 | 3 | 0 | 3 |
| DYNLT1 | NDUFA11 | 0.625433 | 4 | 0 | 4 |
| DYNLT1 | SLC44A3 | 0.623632 | 7 | 0 | 6 |
| DYNLT1 | WDR1 | 0.622444 | 9 | 0 | 7 |
For details and further investigation, click here
