| Full name: ubiquitin C | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 12q24.3 | ||
| Entrez ID: 7316 | HGNC ID: HGNC:12468 | Ensembl Gene: ENSG00000150991 | OMIM ID: 191340 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
UBC involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa03320 | PPAR signaling pathway |
Expression of UBC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UBC | 7316 | 211296_x_at | -0.2533 | 0.1762 | |
| GSE20347 | UBC | 7316 | 211296_x_at | -0.2029 | 0.0048 | |
| GSE23400 | UBC | 7316 | 211296_x_at | -0.2841 | 0.0000 | |
| GSE26886 | UBC | 7316 | 211296_x_at | -0.0334 | 0.8319 | |
| GSE29001 | UBC | 7316 | 211296_x_at | -0.4318 | 0.0965 | |
| GSE38129 | UBC | 7316 | 211296_x_at | -0.2030 | 0.0010 | |
| GSE45670 | UBC | 7316 | 211296_x_at | -0.1324 | 0.0547 | |
| GSE53622 | UBC | 7316 | 38470 | 0.4277 | 0.0000 | |
| GSE53624 | UBC | 7316 | 38470 | 0.0434 | 0.4807 | |
| GSE63941 | UBC | 7316 | 211296_x_at | -0.0891 | 0.6500 | |
| GSE77861 | UBC | 7316 | 211296_x_at | -0.0043 | 0.9748 | |
| GSE97050 | UBC | 7316 | A_24_P681301 | 0.0437 | 0.9076 | |
| SRP007169 | UBC | 7316 | RNAseq | -1.3330 | 0.0362 | |
| SRP008496 | UBC | 7316 | RNAseq | -1.2820 | 0.0011 | |
| SRP064894 | UBC | 7316 | RNAseq | -0.8571 | 0.0000 | |
| SRP133303 | UBC | 7316 | RNAseq | -0.4920 | 0.0029 | |
| SRP159526 | UBC | 7316 | RNAseq | -0.6148 | 0.0629 | |
| SRP193095 | UBC | 7316 | RNAseq | -0.8067 | 0.0000 | |
| SRP219564 | UBC | 7316 | RNAseq | -0.8757 | 0.0781 | |
| TCGA | UBC | 7316 | RNAseq | -0.0063 | 0.8652 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by UBC expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UBC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UBC | 7316 | 5 | 5 | 20 | |
| GSE20123 | UBC | 7316 | 5 | 5 | 20 | |
| GSE43470 | UBC | 7316 | 2 | 0 | 41 | |
| GSE46452 | UBC | 7316 | 9 | 1 | 49 | |
| GSE47630 | UBC | 7316 | 9 | 3 | 28 | |
| GSE54993 | UBC | 7316 | 0 | 5 | 65 | |
| GSE54994 | UBC | 7316 | 4 | 8 | 41 | |
| GSE60625 | UBC | 7316 | 0 | 0 | 11 | |
| GSE74703 | UBC | 7316 | 2 | 0 | 34 | |
| GSE74704 | UBC | 7316 | 3 | 3 | 14 | |
| TCGA | UBC | 7316 | 21 | 12 | 63 |
Total number of gains: 60; Total number of losses: 42; Total Number of normals: 386.
Somatic mutations of UBC:
Generating mutation plots.
Highly correlated genes for UBC:
Showing top 20/167 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UBC | ATP6V1G1 | 0.746651 | 3 | 0 | 3 |
| UBC | FEM1C | 0.660563 | 7 | 0 | 7 |
| UBC | YY1AP1 | 0.652998 | 5 | 0 | 4 |
| UBC | DYNLT1 | 0.638004 | 3 | 0 | 3 |
| UBC | ZNF233 | 0.623888 | 3 | 0 | 3 |
| UBC | PDZRN3 | 0.622344 | 3 | 0 | 3 |
| UBC | KAT2B | 0.618428 | 6 | 0 | 5 |
| UBC | ARPC3 | 0.616077 | 4 | 0 | 3 |
| UBC | TOB1 | 0.603677 | 6 | 0 | 4 |
| UBC | SUCLG1 | 0.603546 | 4 | 0 | 3 |
| UBC | ADIRF | 0.596682 | 6 | 0 | 5 |
| UBC | TEAD1 | 0.595529 | 6 | 0 | 4 |
| UBC | ZNF365 | 0.595336 | 6 | 0 | 5 |
| UBC | ZFP36 | 0.594667 | 5 | 0 | 4 |
| UBC | CRYAB | 0.594349 | 6 | 0 | 4 |
| UBC | MOB4 | 0.592783 | 5 | 0 | 3 |
| UBC | SDHD | 0.591556 | 7 | 0 | 5 |
| UBC | RASAL2 | 0.59147 | 6 | 0 | 5 |
| UBC | EPHA1 | 0.590907 | 3 | 0 | 3 |
| UBC | CRYZL1 | 0.590557 | 5 | 0 | 3 |
For details and further investigation, click here
