| Full name: eukaryotic translation elongation factor 2 | Alias Symbol: EEF-2 | ||
| Type: protein-coding gene | Cytoband: 19p13.3 | ||
| Entrez ID: 1938 | HGNC ID: HGNC:3214 | Ensembl Gene: ENSG00000167658 | OMIM ID: 130610 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
EEF2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04152 | AMPK signaling pathway | |
| hsa04921 | Oxytocin signaling pathway |
Expression of EEF2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EEF2 | 1938 | 204102_s_at | -0.1585 | 0.3625 | |
| GSE20347 | EEF2 | 1938 | 204102_s_at | -0.0078 | 0.9479 | |
| GSE23400 | EEF2 | 1938 | 204102_s_at | -0.0113 | 0.8451 | |
| GSE26886 | EEF2 | 1938 | 204102_s_at | 0.9091 | 0.0017 | |
| GSE29001 | EEF2 | 1938 | 204102_s_at | -0.4415 | 0.1756 | |
| GSE38129 | EEF2 | 1938 | 204102_s_at | -0.0232 | 0.7953 | |
| GSE45670 | EEF2 | 1938 | 204102_s_at | -0.1307 | 0.1345 | |
| GSE53622 | EEF2 | 1938 | 51782 | -0.1108 | 0.0912 | |
| GSE53624 | EEF2 | 1938 | 51782 | 0.0917 | 0.0716 | |
| GSE63941 | EEF2 | 1938 | 204102_s_at | -0.2236 | 0.4294 | |
| GSE77861 | EEF2 | 1938 | 204102_s_at | 0.2008 | 0.2390 | |
| GSE97050 | EEF2 | 1938 | A_24_P87763 | -0.1568 | 0.4402 | |
| SRP007169 | EEF2 | 1938 | RNAseq | -0.8807 | 0.0023 | |
| SRP008496 | EEF2 | 1938 | RNAseq | -0.8499 | 0.0000 | |
| SRP064894 | EEF2 | 1938 | RNAseq | -0.4468 | 0.0410 | |
| SRP133303 | EEF2 | 1938 | RNAseq | -0.4180 | 0.0373 | |
| SRP159526 | EEF2 | 1938 | RNAseq | -0.5306 | 0.0637 | |
| SRP193095 | EEF2 | 1938 | RNAseq | -0.5461 | 0.0000 | |
| SRP219564 | EEF2 | 1938 | RNAseq | -0.3558 | 0.2815 | |
| TCGA | EEF2 | 1938 | RNAseq | -0.1364 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by EEF2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EEF2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EEF2 | 1938 | 5 | 3 | 22 | |
| GSE20123 | EEF2 | 1938 | 4 | 2 | 24 | |
| GSE43470 | EEF2 | 1938 | 1 | 9 | 33 | |
| GSE46452 | EEF2 | 1938 | 47 | 1 | 11 | |
| GSE47630 | EEF2 | 1938 | 5 | 7 | 28 | |
| GSE54993 | EEF2 | 1938 | 16 | 3 | 51 | |
| GSE54994 | EEF2 | 1938 | 8 | 16 | 29 | |
| GSE60625 | EEF2 | 1938 | 9 | 0 | 2 | |
| GSE74703 | EEF2 | 1938 | 1 | 6 | 29 | |
| GSE74704 | EEF2 | 1938 | 1 | 2 | 17 | |
| TCGA | EEF2 | 1938 | 11 | 18 | 67 |
Total number of gains: 108; Total number of losses: 67; Total Number of normals: 313.
Somatic mutations of EEF2:
Generating mutation plots.
Highly correlated genes for EEF2:
Showing top 20/373 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EEF2 | SSBP4 | 0.8168 | 3 | 0 | 3 |
| EEF2 | KRTCAP2 | 0.782461 | 3 | 0 | 3 |
| EEF2 | EIF2D | 0.764789 | 3 | 0 | 3 |
| EEF2 | C1orf198 | 0.760493 | 3 | 0 | 3 |
| EEF2 | MEPCE | 0.747891 | 3 | 0 | 3 |
| EEF2 | SMG9 | 0.746884 | 3 | 0 | 3 |
| EEF2 | MED22 | 0.742312 | 4 | 0 | 3 |
| EEF2 | ADAR | 0.737834 | 3 | 0 | 3 |
| EEF2 | ZBTB26 | 0.734721 | 3 | 0 | 3 |
| EEF2 | PLIN4 | 0.731379 | 3 | 0 | 3 |
| EEF2 | ZBED1 | 0.731279 | 3 | 0 | 3 |
| EEF2 | PPP1R16A | 0.72678 | 3 | 0 | 3 |
| EEF2 | COX6B1 | 0.723969 | 3 | 0 | 3 |
| EEF2 | CAMKK2 | 0.708464 | 4 | 0 | 4 |
| EEF2 | CIC | 0.707916 | 3 | 0 | 3 |
| EEF2 | TNPO3 | 0.707614 | 3 | 0 | 3 |
| EEF2 | CRTC2 | 0.705413 | 3 | 0 | 3 |
| EEF2 | ZNF496 | 0.704702 | 4 | 0 | 3 |
| EEF2 | RPL8 | 0.7046 | 4 | 0 | 3 |
| EEF2 | ESD | 0.701416 | 3 | 0 | 3 |
For details and further investigation, click here
