| Full name: semaphorin 4B | Alias Symbol: SemC|KIAA1745|MGC131831 | ||
| Type: protein-coding gene | Cytoband: 15q25 | ||
| Entrez ID: 10509 | HGNC ID: HGNC:10730 | Ensembl Gene: ENSG00000185033 | OMIM ID: 617029 |
| Drug and gene relationship at DGIdb | |||
SEMA4B involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04360 | Axon guidance |
Expression of SEMA4B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SEMA4B | 10509 | 234725_s_at | -0.1752 | 0.8846 | |
| GSE26886 | SEMA4B | 10509 | 234725_s_at | 0.2054 | 0.5207 | |
| GSE45670 | SEMA4B | 10509 | 234725_s_at | 0.5603 | 0.0086 | |
| GSE53622 | SEMA4B | 10509 | 40305 | -0.2207 | 0.0905 | |
| GSE53624 | SEMA4B | 10509 | 40305 | -0.6242 | 0.0000 | |
| GSE63941 | SEMA4B | 10509 | 234725_s_at | 2.2001 | 0.0076 | |
| GSE77861 | SEMA4B | 10509 | 234725_s_at | 0.3823 | 0.1450 | |
| GSE97050 | SEMA4B | 10509 | A_23_P95165 | 0.2996 | 0.4361 | |
| SRP007169 | SEMA4B | 10509 | RNAseq | -0.2626 | 0.4468 | |
| SRP008496 | SEMA4B | 10509 | RNAseq | -0.1719 | 0.6045 | |
| SRP064894 | SEMA4B | 10509 | RNAseq | 0.1724 | 0.5736 | |
| SRP133303 | SEMA4B | 10509 | RNAseq | 0.2414 | 0.4261 | |
| SRP159526 | SEMA4B | 10509 | RNAseq | -0.5252 | 0.3361 | |
| SRP193095 | SEMA4B | 10509 | RNAseq | 0.1825 | 0.3000 | |
| SRP219564 | SEMA4B | 10509 | RNAseq | -0.6658 | 0.1253 | |
| TCGA | SEMA4B | 10509 | RNAseq | 0.2583 | 0.0002 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by SEMA4B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SEMA4B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SEMA4B | 10509 | 9 | 2 | 19 | |
| GSE20123 | SEMA4B | 10509 | 9 | 2 | 19 | |
| GSE43470 | SEMA4B | 10509 | 5 | 5 | 33 | |
| GSE46452 | SEMA4B | 10509 | 3 | 7 | 49 | |
| GSE47630 | SEMA4B | 10509 | 8 | 11 | 21 | |
| GSE54993 | SEMA4B | 10509 | 4 | 6 | 60 | |
| GSE54994 | SEMA4B | 10509 | 7 | 6 | 40 | |
| GSE60625 | SEMA4B | 10509 | 4 | 0 | 7 | |
| GSE74703 | SEMA4B | 10509 | 4 | 4 | 28 | |
| GSE74704 | SEMA4B | 10509 | 5 | 1 | 14 | |
| TCGA | SEMA4B | 10509 | 18 | 12 | 66 |
Total number of gains: 76; Total number of losses: 56; Total Number of normals: 356.
Somatic mutations of SEMA4B:
Generating mutation plots.
Highly correlated genes for SEMA4B:
Showing top 20/348 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SEMA4B | TUBD1 | 0.735321 | 3 | 0 | 3 |
| SEMA4B | EFNA1 | 0.72745 | 4 | 0 | 4 |
| SEMA4B | SLC9A3R1 | 0.725477 | 5 | 0 | 5 |
| SEMA4B | ABCB6 | 0.724084 | 3 | 0 | 3 |
| SEMA4B | CPNE2 | 0.696949 | 3 | 0 | 3 |
| SEMA4B | SAP130 | 0.696056 | 3 | 0 | 3 |
| SEMA4B | SORD | 0.694987 | 5 | 0 | 5 |
| SEMA4B | GPN1 | 0.691692 | 3 | 0 | 3 |
| SEMA4B | HOXA7 | 0.690645 | 3 | 0 | 3 |
| SEMA4B | GGA2 | 0.688179 | 3 | 0 | 3 |
| SEMA4B | ARNTL2 | 0.68522 | 4 | 0 | 3 |
| SEMA4B | MCCC2 | 0.683996 | 3 | 0 | 3 |
| SEMA4B | USP40 | 0.68314 | 3 | 0 | 3 |
| SEMA4B | STARD5 | 0.682001 | 4 | 0 | 3 |
| SEMA4B | NIPAL1 | 0.678335 | 3 | 0 | 3 |
| SEMA4B | CDK5RAP2 | 0.67694 | 3 | 0 | 3 |
| SEMA4B | GTPBP3 | 0.676664 | 4 | 0 | 4 |
| SEMA4B | ARPC1A | 0.673442 | 3 | 0 | 3 |
| SEMA4B | PPP4C | 0.672277 | 5 | 0 | 4 |
| SEMA4B | PKM | 0.67043 | 5 | 0 | 5 |
For details and further investigation, click here
