| Full name: pappalysin 1 | Alias Symbol: PAPP-A|PAPPA1|IGFBP-4ase|PAPA|ASBABP2|DIPLA1 | ||
| Type: protein-coding gene | Cytoband: 9q33.1 | ||
| Entrez ID: 5069 | HGNC ID: HGNC:8602 | Ensembl Gene: ENSG00000182752 | OMIM ID: 176385 |
| Drug and gene relationship at DGIdb | |||
Expression of PAPPA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PAPPA | 5069 | 228128_x_at | -1.0161 | 0.5111 | |
| GSE20347 | PAPPA | 5069 | 201982_s_at | 0.0044 | 0.9654 | |
| GSE23400 | PAPPA | 5069 | 201982_s_at | -0.0519 | 0.3073 | |
| GSE26886 | PAPPA | 5069 | 1559400_s_at | 0.9870 | 0.0299 | |
| GSE29001 | PAPPA | 5069 | 201981_at | -0.7180 | 0.0071 | |
| GSE38129 | PAPPA | 5069 | 201981_at | -0.0884 | 0.5205 | |
| GSE45670 | PAPPA | 5069 | 228128_x_at | 0.4244 | 0.4922 | |
| GSE53622 | PAPPA | 5069 | 70896 | 0.2236 | 0.1860 | |
| GSE53624 | PAPPA | 5069 | 78380 | 0.4730 | 0.0002 | |
| GSE63941 | PAPPA | 5069 | 224940_s_at | -5.2097 | 0.0003 | |
| GSE77861 | PAPPA | 5069 | 1559400_s_at | 0.0463 | 0.7363 | |
| GSE97050 | PAPPA | 5069 | A_33_P3599591 | 1.0950 | 0.1064 | |
| SRP007169 | PAPPA | 5069 | RNAseq | 0.9666 | 0.2091 | |
| SRP008496 | PAPPA | 5069 | RNAseq | 0.9973 | 0.0147 | |
| SRP064894 | PAPPA | 5069 | RNAseq | 0.8650 | 0.0318 | |
| SRP133303 | PAPPA | 5069 | RNAseq | 0.9845 | 0.0186 | |
| SRP159526 | PAPPA | 5069 | RNAseq | -0.3129 | 0.6101 | |
| SRP193095 | PAPPA | 5069 | RNAseq | 2.2783 | 0.0000 | |
| SRP219564 | PAPPA | 5069 | RNAseq | 0.6847 | 0.1725 | |
| TCGA | PAPPA | 5069 | RNAseq | 0.0096 | 0.9503 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by PAPPA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PAPPA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PAPPA | 5069 | 5 | 10 | 15 | |
| GSE20123 | PAPPA | 5069 | 4 | 10 | 16 | |
| GSE43470 | PAPPA | 5069 | 4 | 3 | 36 | |
| GSE46452 | PAPPA | 5069 | 6 | 13 | 40 | |
| GSE47630 | PAPPA | 5069 | 3 | 16 | 21 | |
| GSE54993 | PAPPA | 5069 | 3 | 3 | 64 | |
| GSE54994 | PAPPA | 5069 | 9 | 11 | 33 | |
| GSE60625 | PAPPA | 5069 | 0 | 0 | 11 | |
| GSE74703 | PAPPA | 5069 | 4 | 3 | 29 | |
| GSE74704 | PAPPA | 5069 | 2 | 7 | 11 | |
| TCGA | PAPPA | 5069 | 28 | 22 | 46 |
Total number of gains: 68; Total number of losses: 98; Total Number of normals: 322.
Somatic mutations of PAPPA:
Generating mutation plots.
Highly correlated genes for PAPPA:
Showing top 20/215 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PAPPA | CPT1C | 0.754148 | 3 | 0 | 3 |
| PAPPA | LPAR3 | 0.7521 | 3 | 0 | 3 |
| PAPPA | BDKRB2 | 0.738862 | 3 | 0 | 3 |
| PAPPA | RNF31 | 0.723246 | 3 | 0 | 3 |
| PAPPA | TNFRSF10B | 0.719842 | 3 | 0 | 3 |
| PAPPA | INHBE | 0.715615 | 3 | 0 | 3 |
| PAPPA | PPP1R9B | 0.715578 | 3 | 0 | 3 |
| PAPPA | WDR20 | 0.713882 | 3 | 0 | 3 |
| PAPPA | TRIM61 | 0.711874 | 4 | 0 | 3 |
| PAPPA | MICAL1 | 0.710754 | 3 | 0 | 3 |
| PAPPA | PPP3CC | 0.693423 | 4 | 0 | 4 |
| PAPPA | DPPA4 | 0.691922 | 3 | 0 | 3 |
| PAPPA | KLHL17 | 0.69168 | 3 | 0 | 3 |
| PAPPA | FNIP1 | 0.680903 | 3 | 0 | 3 |
| PAPPA | FABP4 | 0.680064 | 4 | 0 | 3 |
| PAPPA | RARS2 | 0.677182 | 3 | 0 | 3 |
| PAPPA | C19orf47 | 0.674326 | 4 | 0 | 3 |
| PAPPA | JAG1 | 0.673766 | 3 | 0 | 3 |
| PAPPA | C11orf96 | 0.67156 | 3 | 0 | 3 |
| PAPPA | VPS37A | 0.671296 | 3 | 0 | 3 |
For details and further investigation, click here
