WNT5A

 

Full name: Wnt family member 5A Alias Symbol: hWNT5A
Type: protein-coding gene Cytoband: 3p14.3
Entrez ID: 7474 HGNC ID: HGNC:12784 Ensembl Gene: ENSG00000114251 OMIM ID: 164975
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

WNT5A involved pathways:

KEGG pathway Description View
hsa04150mTOR signaling pathway
hsa04310Wnt signaling pathway
hsa04360Axon guidance
hsa04390Hippo signaling pathway
hsa04550Signaling pathways regulating pluripotency of stem cells
hsa04916Melanogenesis
hsa05166HTLV-I infection
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05217Basal cell carcinoma

 

Expression of WNT5A:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 WNT5A 7474 205990_s_at -0.1954 0.9158
GSE20347 WNT5A 7474 205990_s_at -0.8638 0.0258
GSE23400 WNT5A 7474 205990_s_at -0.0835 0.6873
GSE26886 WNT5A 7474 205990_s_at -1.4575 0.0211
GSE29001 WNT5A 7474 205990_s_at -1.2360 0.0119
GSE38129 WNT5A 7474 205990_s_at -0.1585 0.7446
GSE45670 WNT5A 7474 205990_s_at -0.0298 0.9483
GSE53622 WNT5A 7474 31958 0.1627 0.3574
GSE53624 WNT5A 7474 31958 0.0246 0.8499
GSE63941 WNT5A 7474 205990_s_at -3.4365 0.0670
GSE77861 WNT5A 7474 205990_s_at -0.3110 0.5209
GSE97050 WNT5A 7474 A_33_P3341499 0.1060 0.8774
SRP007169 WNT5A 7474 RNAseq -0.6551 0.3171
SRP008496 WNT5A 7474 RNAseq -0.1401 0.7495
SRP064894 WNT5A 7474 RNAseq -0.1932 0.6425
SRP133303 WNT5A 7474 RNAseq 0.2928 0.4148
SRP159526 WNT5A 7474 RNAseq 1.0337 0.0826
SRP193095 WNT5A 7474 RNAseq 0.6138 0.0410
SRP219564 WNT5A 7474 RNAseq -0.0874 0.8863
TCGA WNT5A 7474 RNAseq 0.5516 0.0000

Upregulated datasets: 0; Downregulated datasets: 2.  

 

Survival by WNT5A expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of WNT5A:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 WNT5A 7474 0 16 14
GSE20123 WNT5A 7474 0 17 13
GSE43470 WNT5A 7474 0 17 26
GSE46452 WNT5A 7474 2 17 40
GSE47630 WNT5A 7474 1 24 15
GSE54993 WNT5A 7474 6 2 62
GSE54994 WNT5A 7474 0 32 21
GSE60625 WNT5A 7474 5 0 6
GSE74703 WNT5A 7474 0 14 22
GSE74704 WNT5A 7474 0 11 9
TCGA WNT5A 7474 0 79 17

Total number of gains: 14; Total number of losses: 229; Total Number of normals: 245.  

 

Somatic mutations of WNT5A:

 

Generating mutation plots.

 

Highly correlated genes for WNT5A:

 

Showing top 20/394 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
WNT5ALRRC280.725286303
WNT5ATTC230.694845303
WNT5ACCNYL10.692962404
WNT5AVPS250.688292303
WNT5ATWF20.684345303
WNT5AKDM1B0.680894303
WNT5AMTMR100.680298303
WNT5ATMEM184C0.674685303
WNT5AMGST10.674091404
WNT5AEIF2B20.673677404
WNT5ASYAP10.671005303
WNT5ASWAP700.667064504
WNT5ACAPZA10.664556404
WNT5ALDHD0.658981303
WNT5ASPRR1B0.658081604
WNT5AFAHD10.657992303
WNT5AMRPS110.657626303
WNT5AIL1R20.657024605
WNT5AAVEN0.656095404
WNT5AKLF30.65365404

For details and further investigation, click here