| Full name: peptidylprolyl cis/trans isomerase, NIMA-interacting 1 | Alias Symbol: dod | ||
| Type: protein-coding gene | Cytoband: 19p13 | ||
| Entrez ID: 5300 | HGNC ID: HGNC:8988 | Ensembl Gene: ENSG00000127445 | OMIM ID: 601052 |
| Drug and gene relationship at DGIdb | |||
PIN1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04622 | RIG-I-like receptor signaling pathway |
Expression of PIN1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PIN1 | 5300 | 202927_at | -0.1868 | 0.7709 | |
| GSE20347 | PIN1 | 5300 | 202927_at | -0.0552 | 0.7719 | |
| GSE23400 | PIN1 | 5300 | 202927_at | 0.1063 | 0.0589 | |
| GSE26886 | PIN1 | 5300 | 202927_at | 0.6202 | 0.0067 | |
| GSE29001 | PIN1 | 5300 | 202927_at | 0.1665 | 0.5722 | |
| GSE38129 | PIN1 | 5300 | 202927_at | -0.1004 | 0.5086 | |
| GSE45670 | PIN1 | 5300 | 202927_at | -0.0733 | 0.6641 | |
| GSE53622 | PIN1 | 5300 | 42038 | 0.0261 | 0.6840 | |
| GSE53624 | PIN1 | 5300 | 42038 | 0.3076 | 0.0000 | |
| GSE63941 | PIN1 | 5300 | 202927_at | -0.3002 | 0.4274 | |
| GSE77861 | PIN1 | 5300 | 202927_at | 0.1907 | 0.2275 | |
| GSE97050 | PIN1 | 5300 | A_23_P67162 | -0.0442 | 0.8404 | |
| SRP007169 | PIN1 | 5300 | RNAseq | -0.6972 | 0.0746 | |
| SRP008496 | PIN1 | 5300 | RNAseq | -0.2163 | 0.3505 | |
| SRP064894 | PIN1 | 5300 | RNAseq | 0.4704 | 0.1367 | |
| SRP133303 | PIN1 | 5300 | RNAseq | 0.1763 | 0.2675 | |
| SRP159526 | PIN1 | 5300 | RNAseq | 0.1541 | 0.4300 | |
| SRP193095 | PIN1 | 5300 | RNAseq | -0.0454 | 0.6742 | |
| SRP219564 | PIN1 | 5300 | RNAseq | 0.3066 | 0.5000 | |
| TCGA | PIN1 | 5300 | RNAseq | 0.0109 | 0.8342 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PIN1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PIN1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PIN1 | 5300 | 4 | 2 | 24 | |
| GSE20123 | PIN1 | 5300 | 3 | 1 | 26 | |
| GSE43470 | PIN1 | 5300 | 3 | 6 | 34 | |
| GSE46452 | PIN1 | 5300 | 47 | 1 | 11 | |
| GSE47630 | PIN1 | 5300 | 5 | 7 | 28 | |
| GSE54993 | PIN1 | 5300 | 16 | 3 | 51 | |
| GSE54994 | PIN1 | 5300 | 7 | 13 | 33 | |
| GSE60625 | PIN1 | 5300 | 9 | 0 | 2 | |
| GSE74703 | PIN1 | 5300 | 3 | 4 | 29 | |
| GSE74704 | PIN1 | 5300 | 0 | 1 | 19 | |
| TCGA | PIN1 | 5300 | 12 | 17 | 67 |
Total number of gains: 109; Total number of losses: 55; Total Number of normals: 324.
Somatic mutations of PIN1:
Generating mutation plots.
Highly correlated genes for PIN1:
Showing top 20/534 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PIN1 | FBXW9 | 0.802841 | 4 | 0 | 4 |
| PIN1 | EIF2D | 0.773723 | 3 | 0 | 3 |
| PIN1 | MRPL38 | 0.763838 | 4 | 0 | 4 |
| PIN1 | RERE | 0.759041 | 3 | 0 | 3 |
| PIN1 | ZNF766 | 0.755437 | 3 | 0 | 3 |
| PIN1 | ING4 | 0.746172 | 3 | 0 | 3 |
| PIN1 | NAA60 | 0.737493 | 3 | 0 | 3 |
| PIN1 | MED26 | 0.714634 | 3 | 0 | 3 |
| PIN1 | PPP1R9A | 0.714323 | 3 | 0 | 3 |
| PIN1 | SUFU | 0.712885 | 3 | 0 | 3 |
| PIN1 | FHOD3 | 0.694279 | 3 | 0 | 3 |
| PIN1 | TSR2 | 0.686523 | 5 | 0 | 3 |
| PIN1 | SMU1 | 0.685342 | 3 | 0 | 3 |
| PIN1 | TTC26 | 0.684752 | 3 | 0 | 3 |
| PIN1 | DAZAP1 | 0.682927 | 3 | 0 | 3 |
| PIN1 | ADRM1 | 0.680082 | 5 | 0 | 5 |
| PIN1 | EXOC3L1 | 0.67632 | 3 | 0 | 3 |
| PIN1 | NSUN3 | 0.676173 | 3 | 0 | 3 |
| PIN1 | RHEB | 0.675366 | 5 | 0 | 4 |
| PIN1 | COX6B1 | 0.674797 | 3 | 0 | 3 |
For details and further investigation, click here
