| Full name: late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 | Alias Symbol: MP1|MAPBP|Ragulator3 | ||
| Type: protein-coding gene | Cytoband: 4q23 | ||
| Entrez ID: 8649 | HGNC ID: HGNC:15606 | Ensembl Gene: ENSG00000109270 | OMIM ID: 603296 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
LAMTOR3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway | |
| hsa04150 | mTOR signaling pathway |
Expression of LAMTOR3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LAMTOR3 | 8649 | 217971_at | -0.3063 | 0.5464 | |
| GSE20347 | LAMTOR3 | 8649 | 217971_at | -0.6867 | 0.0000 | |
| GSE23400 | LAMTOR3 | 8649 | 217971_at | -0.5044 | 0.0000 | |
| GSE26886 | LAMTOR3 | 8649 | 217971_at | -0.8252 | 0.0001 | |
| GSE29001 | LAMTOR3 | 8649 | 217971_at | -0.5739 | 0.0589 | |
| GSE38129 | LAMTOR3 | 8649 | 217971_at | -0.4135 | 0.0054 | |
| GSE45670 | LAMTOR3 | 8649 | 217971_at | -0.2792 | 0.0934 | |
| GSE53622 | LAMTOR3 | 8649 | 23219 | -0.3418 | 0.0000 | |
| GSE53624 | LAMTOR3 | 8649 | 23219 | -0.6165 | 0.0000 | |
| GSE63941 | LAMTOR3 | 8649 | 217971_at | -0.2322 | 0.5963 | |
| GSE77861 | LAMTOR3 | 8649 | 217971_at | -0.8806 | 0.0044 | |
| GSE97050 | LAMTOR3 | 8649 | A_23_P110362 | -0.3168 | 0.2719 | |
| SRP007169 | LAMTOR3 | 8649 | RNAseq | -1.3121 | 0.0016 | |
| SRP008496 | LAMTOR3 | 8649 | RNAseq | -1.2609 | 0.0000 | |
| SRP064894 | LAMTOR3 | 8649 | RNAseq | -0.8110 | 0.0000 | |
| SRP133303 | LAMTOR3 | 8649 | RNAseq | -0.3542 | 0.0591 | |
| SRP159526 | LAMTOR3 | 8649 | RNAseq | -1.0120 | 0.0000 | |
| SRP193095 | LAMTOR3 | 8649 | RNAseq | -0.9700 | 0.0000 | |
| SRP219564 | LAMTOR3 | 8649 | RNAseq | -1.0145 | 0.0004 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by LAMTOR3 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of LAMTOR3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LAMTOR3 | 8649 | 0 | 12 | 18 | |
| GSE20123 | LAMTOR3 | 8649 | 0 | 12 | 18 | |
| GSE43470 | LAMTOR3 | 8649 | 0 | 13 | 30 | |
| GSE46452 | LAMTOR3 | 8649 | 1 | 36 | 22 | |
| GSE47630 | LAMTOR3 | 8649 | 0 | 20 | 20 | |
| GSE54993 | LAMTOR3 | 8649 | 9 | 0 | 61 | |
| GSE54994 | LAMTOR3 | 8649 | 1 | 11 | 41 | |
| GSE60625 | LAMTOR3 | 8649 | 0 | 3 | 8 | |
| GSE74703 | LAMTOR3 | 8649 | 0 | 11 | 25 | |
| GSE74704 | LAMTOR3 | 8649 | 0 | 6 | 14 | |
| TCGA | LAMTOR3 | 8649 | 8 | 40 | 48 |
Total number of gains: 19; Total number of losses: 164; Total Number of normals: 305.
Somatic mutations of LAMTOR3:
Generating mutation plots.
Highly correlated genes for LAMTOR3:
Showing top 20/1671 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LAMTOR3 | NANS | 0.778487 | 3 | 0 | 3 |
| LAMTOR3 | TMEM234 | 0.774409 | 4 | 0 | 4 |
| LAMTOR3 | PAIP2 | 0.772752 | 3 | 0 | 3 |
| LAMTOR3 | SPA17 | 0.769906 | 3 | 0 | 3 |
| LAMTOR3 | OPHN1 | 0.758871 | 4 | 0 | 4 |
| LAMTOR3 | ZNF416 | 0.754659 | 5 | 0 | 5 |
| LAMTOR3 | TP53RK | 0.747448 | 3 | 0 | 3 |
| LAMTOR3 | PRPF38A | 0.743973 | 4 | 0 | 4 |
| LAMTOR3 | SCP2 | 0.743845 | 12 | 0 | 11 |
| LAMTOR3 | ZNF626 | 0.743425 | 5 | 0 | 5 |
| LAMTOR3 | PIH1D2 | 0.742882 | 3 | 0 | 3 |
| LAMTOR3 | EIF4E | 0.74216 | 11 | 0 | 11 |
| LAMTOR3 | GPBP1 | 0.741155 | 3 | 0 | 3 |
| LAMTOR3 | MAT2B | 0.739226 | 4 | 0 | 4 |
| LAMTOR3 | EXOC6B | 0.739075 | 3 | 0 | 3 |
| LAMTOR3 | C5orf51 | 0.738939 | 3 | 0 | 3 |
| LAMTOR3 | CUL3 | 0.737913 | 11 | 0 | 11 |
| LAMTOR3 | AP3M1 | 0.737888 | 4 | 0 | 4 |
| LAMTOR3 | GPCPD1 | 0.736949 | 3 | 0 | 3 |
| LAMTOR3 | FBXO8 | 0.736656 | 7 | 0 | 6 |
For details and further investigation, click here
