| Full name: eukaryotic translation initiation factor 4E binding protein 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 10q22.1 | ||
| Entrez ID: 1979 | HGNC ID: HGNC:3289 | Ensembl Gene: ENSG00000148730 | OMIM ID: 602224 |
| Drug and gene relationship at DGIdb | |||
EIF4EBP2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04213 | Longevity regulating pathway - multiple species |
Expression of EIF4EBP2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EIF4EBP2 | 1979 | 208770_s_at | 0.0361 | 0.9518 | |
| GSE20347 | EIF4EBP2 | 1979 | 208770_s_at | -0.6561 | 0.0000 | |
| GSE23400 | EIF4EBP2 | 1979 | 208770_s_at | -0.5873 | 0.0000 | |
| GSE26886 | EIF4EBP2 | 1979 | 224653_at | -0.7093 | 0.0000 | |
| GSE29001 | EIF4EBP2 | 1979 | 208770_s_at | -0.7004 | 0.0013 | |
| GSE38129 | EIF4EBP2 | 1979 | 208770_s_at | -0.6143 | 0.0000 | |
| GSE45670 | EIF4EBP2 | 1979 | 224653_at | -0.3734 | 0.0007 | |
| GSE53622 | EIF4EBP2 | 1979 | 119038 | -0.9120 | 0.0000 | |
| GSE53624 | EIF4EBP2 | 1979 | 119038 | -0.7633 | 0.0000 | |
| GSE63941 | EIF4EBP2 | 1979 | 224653_at | -0.8433 | 0.0779 | |
| GSE77861 | EIF4EBP2 | 1979 | 208770_s_at | -0.6892 | 0.0004 | |
| GSE97050 | EIF4EBP2 | 1979 | A_23_P115922 | -0.5695 | 0.0834 | |
| SRP007169 | EIF4EBP2 | 1979 | RNAseq | -1.9930 | 0.0000 | |
| SRP008496 | EIF4EBP2 | 1979 | RNAseq | -1.6111 | 0.0000 | |
| SRP064894 | EIF4EBP2 | 1979 | RNAseq | -1.0228 | 0.0000 | |
| SRP133303 | EIF4EBP2 | 1979 | RNAseq | -0.3339 | 0.0540 | |
| SRP159526 | EIF4EBP2 | 1979 | RNAseq | -0.5428 | 0.0429 | |
| SRP193095 | EIF4EBP2 | 1979 | RNAseq | -0.7217 | 0.0000 | |
| SRP219564 | EIF4EBP2 | 1979 | RNAseq | -0.8754 | 0.0015 | |
| TCGA | EIF4EBP2 | 1979 | RNAseq | -0.2103 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by EIF4EBP2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EIF4EBP2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EIF4EBP2 | 1979 | 2 | 4 | 24 | |
| GSE20123 | EIF4EBP2 | 1979 | 2 | 3 | 25 | |
| GSE43470 | EIF4EBP2 | 1979 | 1 | 7 | 35 | |
| GSE46452 | EIF4EBP2 | 1979 | 0 | 11 | 48 | |
| GSE47630 | EIF4EBP2 | 1979 | 2 | 14 | 24 | |
| GSE54993 | EIF4EBP2 | 1979 | 7 | 0 | 63 | |
| GSE54994 | EIF4EBP2 | 1979 | 2 | 12 | 39 | |
| GSE60625 | EIF4EBP2 | 1979 | 0 | 0 | 11 | |
| GSE74703 | EIF4EBP2 | 1979 | 1 | 4 | 31 | |
| GSE74704 | EIF4EBP2 | 1979 | 1 | 1 | 18 | |
| TCGA | EIF4EBP2 | 1979 | 9 | 23 | 64 |
Total number of gains: 27; Total number of losses: 79; Total Number of normals: 382.
Somatic mutations of EIF4EBP2:
Generating mutation plots.
Highly correlated genes for EIF4EBP2:
Showing top 20/1356 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EIF4EBP2 | GYS2 | 0.770361 | 9 | 0 | 9 |
| EIF4EBP2 | AIF1L | 0.761971 | 5 | 0 | 5 |
| EIF4EBP2 | PCBP1-AS1 | 0.758302 | 3 | 0 | 3 |
| EIF4EBP2 | SFTA2 | 0.753075 | 3 | 0 | 3 |
| EIF4EBP2 | GDPD3 | 0.743283 | 9 | 0 | 9 |
| EIF4EBP2 | KRT78 | 0.740711 | 5 | 0 | 5 |
| EIF4EBP2 | CRISP3 | 0.738931 | 9 | 0 | 9 |
| EIF4EBP2 | TRIP10 | 0.732979 | 10 | 0 | 10 |
| EIF4EBP2 | UBL3 | 0.732163 | 10 | 0 | 10 |
| EIF4EBP2 | SORT1 | 0.731771 | 11 | 0 | 10 |
| EIF4EBP2 | SHROOM3 | 0.731275 | 6 | 0 | 6 |
| EIF4EBP2 | FNDC4 | 0.729678 | 10 | 0 | 10 |
| EIF4EBP2 | PAIP2B | 0.729112 | 10 | 0 | 9 |
| EIF4EBP2 | EIF4E3 | 0.728915 | 6 | 0 | 5 |
| EIF4EBP2 | FAM214A | 0.728857 | 5 | 0 | 5 |
| EIF4EBP2 | SCNN1B | 0.726697 | 9 | 0 | 9 |
| EIF4EBP2 | SNORA68 | 0.726648 | 3 | 0 | 3 |
| EIF4EBP2 | ATP6V1C2 | 0.726599 | 3 | 0 | 3 |
| EIF4EBP2 | MAPK3 | 0.726323 | 9 | 0 | 9 |
| EIF4EBP2 | MTMR10 | 0.720841 | 7 | 0 | 7 |
For details and further investigation, click here
