GART

 

Full name: phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase Alias Symbol: GARS-AIRS-GART
Type: protein-coding gene Cytoband: 21q22.11
Entrez ID: 2618 HGNC ID: HGNC:4163 Ensembl Gene: ENSG00000159131 OMIM ID: 138440
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of GART:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GART 2618 212378_at 0.9504 0.0432
GSE20347 GART 2618 212378_at 0.6602 0.0007
GSE23400 GART 2618 212378_at 0.7435 0.0000
GSE26886 GART 2618 212378_at -0.1203 0.5984
GSE29001 GART 2618 212378_at 0.7986 0.0102
GSE38129 GART 2618 212378_at 0.8877 0.0000
GSE45670 GART 2618 212378_at 0.7379 0.0000
GSE53622 GART 2618 103884 0.5290 0.0000
GSE53624 GART 2618 103884 0.7651 0.0000
GSE63941 GART 2618 212378_at 1.3290 0.0140
GSE77861 GART 2618 212379_at 0.1188 0.4623
GSE97050 GART 2618 A_23_P80098 0.5708 0.2242
SRP007169 GART 2618 RNAseq 1.0170 0.0294
SRP008496 GART 2618 RNAseq 1.0267 0.0002
SRP064894 GART 2618 RNAseq 0.6787 0.0013
SRP133303 GART 2618 RNAseq 0.2510 0.0747
SRP159526 GART 2618 RNAseq 0.3228 0.2059
SRP193095 GART 2618 RNAseq 0.2714 0.0022
SRP219564 GART 2618 RNAseq 0.1526 0.6682
TCGA GART 2618 RNAseq 0.1618 0.0009

Upregulated datasets: 3; Downregulated datasets: 0.  

 

Survival by GART expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of GART:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GART 2618 2 8 20
GSE20123 GART 2618 2 9 19
GSE43470 GART 2618 3 9 31
GSE46452 GART 2618 1 21 37
GSE47630 GART 2618 6 17 17
GSE54993 GART 2618 9 1 60
GSE54994 GART 2618 1 9 43
GSE60625 GART 2618 0 0 11
GSE74703 GART 2618 3 6 27
GSE74704 GART 2618 1 4 15
TCGA GART 2618 9 35 52

Total number of gains: 37; Total number of losses: 119; Total Number of normals: 332.  

 

Somatic mutations of GART:

 

Generating mutation plots.

 

Highly correlated genes for GART:

 

Showing top 20/1723 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GARTPPP1R9B0.828145303
GARTCENPE0.76014909
GARTRRP360.752361505
GARTCPSF60.748965909
GARTTSPAN170.748423404
GARTPRKDC0.7483621009
GARTSHCBP10.74225210010
GARTCCNA20.741459909
GARTDEPDC10.73985110010
GARTGPR1530.737507303
GARTCDC200.73610810010
GARTEME10.733315403
GARTMRPL420.732201808
GARTTTK0.73167810010
GARTDHX330.730591606
GARTCMIP0.728442505
GARTRHBDF20.728391505
GARTATAD20.72651411010
GARTHEATR10.72584710010
GARTDONSON0.72544113011

For details and further investigation, click here