| Full name: ER membrane protein complex subunit 7 | Alias Symbol: C11orf3 | ||
| Type: protein-coding gene | Cytoband: 15q14 | ||
| Entrez ID: 56851 | HGNC ID: HGNC:24301 | Ensembl Gene: ENSG00000134153 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of EMC7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EMC7 | 56851 | 217898_at | -0.2552 | 0.5515 | |
| GSE20347 | EMC7 | 56851 | 217898_at | 0.2239 | 0.2513 | |
| GSE23400 | EMC7 | 56851 | 217898_at | 0.2124 | 0.0061 | |
| GSE26886 | EMC7 | 56851 | 217898_at | -0.4583 | 0.0157 | |
| GSE29001 | EMC7 | 56851 | 217898_at | 0.0601 | 0.8511 | |
| GSE38129 | EMC7 | 56851 | 217898_at | 0.1930 | 0.1205 | |
| GSE45670 | EMC7 | 56851 | 217898_at | 0.0861 | 0.4534 | |
| GSE53622 | EMC7 | 56851 | 58623 | -0.0276 | 0.5763 | |
| GSE53624 | EMC7 | 56851 | 58623 | 0.1665 | 0.0000 | |
| GSE63941 | EMC7 | 56851 | 217898_at | -1.1800 | 0.0097 | |
| GSE77861 | EMC7 | 56851 | 217898_at | 0.0740 | 0.6969 | |
| SRP007169 | EMC7 | 56851 | RNAseq | -0.2149 | 0.5514 | |
| SRP008496 | EMC7 | 56851 | RNAseq | 0.0203 | 0.9355 | |
| SRP064894 | EMC7 | 56851 | RNAseq | 0.0370 | 0.8086 | |
| SRP133303 | EMC7 | 56851 | RNAseq | 0.4182 | 0.0014 | |
| SRP159526 | EMC7 | 56851 | RNAseq | 0.1413 | 0.6596 | |
| SRP193095 | EMC7 | 56851 | RNAseq | -0.0564 | 0.6333 | |
| SRP219564 | EMC7 | 56851 | RNAseq | -0.0846 | 0.7961 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by EMC7 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of EMC7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EMC7 | 56851 | 3 | 6 | 21 | |
| GSE20123 | EMC7 | 56851 | 3 | 6 | 21 | |
| GSE43470 | EMC7 | 56851 | 4 | 4 | 35 | |
| GSE46452 | EMC7 | 56851 | 3 | 7 | 49 | |
| GSE47630 | EMC7 | 56851 | 8 | 11 | 21 | |
| GSE54993 | EMC7 | 56851 | 4 | 6 | 60 | |
| GSE54994 | EMC7 | 56851 | 5 | 8 | 40 | |
| GSE60625 | EMC7 | 56851 | 4 | 0 | 7 | |
| GSE74703 | EMC7 | 56851 | 4 | 3 | 29 | |
| GSE74704 | EMC7 | 56851 | 2 | 5 | 13 | |
| TCGA | EMC7 | 56851 | 13 | 17 | 66 |
Total number of gains: 53; Total number of losses: 73; Total Number of normals: 362.
Somatic mutations of EMC7:
Generating mutation plots.
Highly correlated genes for EMC7:
Showing top 20/79 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EMC7 | AVEN | 0.690349 | 10 | 0 | 9 |
| EMC7 | RPS17 | 0.687437 | 3 | 0 | 3 |
| EMC7 | IBTK | 0.676302 | 3 | 0 | 3 |
| EMC7 | LYSMD3 | 0.676181 | 3 | 0 | 3 |
| EMC7 | LAPTM4A | 0.675414 | 4 | 0 | 4 |
| EMC7 | RAB1A | 0.654885 | 5 | 0 | 4 |
| EMC7 | MRPL46 | 0.650135 | 7 | 0 | 6 |
| EMC7 | ROCK2 | 0.647281 | 4 | 0 | 4 |
| EMC7 | AQR | 0.635484 | 8 | 0 | 6 |
| EMC7 | NDUFA6 | 0.635245 | 3 | 0 | 3 |
| EMC7 | KIDINS220 | 0.632797 | 3 | 0 | 3 |
| EMC7 | SLC30A4 | 0.625936 | 3 | 0 | 3 |
| EMC7 | DHX29 | 0.606081 | 4 | 0 | 3 |
| EMC7 | OR5P2 | 0.599412 | 3 | 0 | 3 |
| EMC7 | NCKAP5 | 0.598474 | 3 | 0 | 3 |
| EMC7 | DDX1 | 0.594379 | 5 | 0 | 4 |
| EMC7 | RPLP0 | 0.593041 | 3 | 0 | 3 |
| EMC7 | AFF4 | 0.59241 | 3 | 0 | 3 |
| EMC7 | ZNF770 | 0.59075 | 4 | 0 | 3 |
| EMC7 | MGLL | 0.590129 | 3 | 0 | 3 |
For details and further investigation, click here
