| Full name: inhibitor of Bruton tyrosine kinase | Alias Symbol: DKFZP564B116|BTBD26 | ||
| Type: protein-coding gene | Cytoband: 6q14.1 | ||
| Entrez ID: 25998 | HGNC ID: HGNC:17853 | Ensembl Gene: ENSG00000005700 | OMIM ID: 606457 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of IBTK:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IBTK | 25998 | 210970_s_at | -0.7592 | 0.1570 | |
| GSE20347 | IBTK | 25998 | 210970_s_at | -0.6359 | 0.0000 | |
| GSE23400 | IBTK | 25998 | 210970_s_at | -0.3721 | 0.0000 | |
| GSE26886 | IBTK | 25998 | 210970_s_at | -0.8608 | 0.0054 | |
| GSE29001 | IBTK | 25998 | 210970_s_at | -0.5124 | 0.0274 | |
| GSE38129 | IBTK | 25998 | 210970_s_at | -0.5940 | 0.0000 | |
| GSE45670 | IBTK | 25998 | 210970_s_at | -0.1930 | 0.0786 | |
| GSE53622 | IBTK | 25998 | 84142 | -0.4101 | 0.0000 | |
| GSE53624 | IBTK | 25998 | 84142 | -0.4498 | 0.0000 | |
| GSE63941 | IBTK | 25998 | 210970_s_at | -1.3198 | 0.0067 | |
| GSE77861 | IBTK | 25998 | 210970_s_at | -0.4417 | 0.0906 | |
| GSE97050 | IBTK | 25998 | A_23_P358995 | -0.3020 | 0.1927 | |
| SRP007169 | IBTK | 25998 | RNAseq | -0.3364 | 0.3516 | |
| SRP008496 | IBTK | 25998 | RNAseq | -0.0481 | 0.8082 | |
| SRP064894 | IBTK | 25998 | RNAseq | -0.3344 | 0.1216 | |
| SRP133303 | IBTK | 25998 | RNAseq | 0.0155 | 0.8977 | |
| SRP159526 | IBTK | 25998 | RNAseq | -0.3693 | 0.1318 | |
| SRP193095 | IBTK | 25998 | RNAseq | -0.6599 | 0.0000 | |
| SRP219564 | IBTK | 25998 | RNAseq | -0.4098 | 0.1470 | |
| TCGA | IBTK | 25998 | RNAseq | -0.2531 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by IBTK expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IBTK:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IBTK | 25998 | 1 | 4 | 25 | |
| GSE20123 | IBTK | 25998 | 1 | 3 | 26 | |
| GSE43470 | IBTK | 25998 | 2 | 1 | 40 | |
| GSE46452 | IBTK | 25998 | 2 | 11 | 46 | |
| GSE47630 | IBTK | 25998 | 8 | 6 | 26 | |
| GSE54993 | IBTK | 25998 | 3 | 2 | 65 | |
| GSE54994 | IBTK | 25998 | 8 | 7 | 38 | |
| GSE60625 | IBTK | 25998 | 0 | 1 | 10 | |
| GSE74703 | IBTK | 25998 | 2 | 1 | 33 | |
| GSE74704 | IBTK | 25998 | 0 | 2 | 18 | |
| TCGA | IBTK | 25998 | 7 | 21 | 68 |
Total number of gains: 34; Total number of losses: 59; Total Number of normals: 395.
Somatic mutations of IBTK:
Generating mutation plots.
Highly correlated genes for IBTK:
Showing top 20/946 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IBTK | RAB18 | 0.780214 | 3 | 0 | 3 |
| IBTK | DPY19L3 | 0.766332 | 3 | 0 | 3 |
| IBTK | IMPACT | 0.749965 | 3 | 0 | 3 |
| IBTK | UBE2G2 | 0.742676 | 3 | 0 | 3 |
| IBTK | UBQLN2 | 0.738489 | 3 | 0 | 3 |
| IBTK | FNIP1 | 0.735308 | 3 | 0 | 3 |
| IBTK | ZNF217 | 0.728238 | 3 | 0 | 3 |
| IBTK | CSNK1A1 | 0.725179 | 6 | 0 | 6 |
| IBTK | FAM122A | 0.723431 | 3 | 0 | 3 |
| IBTK | ZCCHC9 | 0.722232 | 4 | 0 | 3 |
| IBTK | RWDD4 | 0.713563 | 3 | 0 | 3 |
| IBTK | RDX | 0.710044 | 3 | 0 | 3 |
| IBTK | PSMD7 | 0.708635 | 3 | 0 | 3 |
| IBTK | THUMPD3 | 0.706294 | 3 | 0 | 3 |
| IBTK | ATG2B | 0.697485 | 3 | 0 | 3 |
| IBTK | ST5 | 0.695739 | 4 | 0 | 3 |
| IBTK | SLC17A5 | 0.694814 | 7 | 0 | 6 |
| IBTK | YAP1 | 0.69372 | 4 | 0 | 3 |
| IBTK | HOOK3 | 0.686025 | 6 | 0 | 5 |
| IBTK | FAM174A | 0.685614 | 5 | 0 | 4 |
For details and further investigation, click here
