| Full name: protein phosphatase 1 regulatory subunit 12A | Alias Symbol: MBS|M130 | ||
| Type: protein-coding gene | Cytoband: 12q21.2-q21.31 | ||
| Entrez ID: 4659 | HGNC ID: HGNC:7618 | Ensembl Gene: ENSG00000058272 | OMIM ID: 602021 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
PPP1R12A involved pathways:
Expression of PPP1R12A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPP1R12A | 4659 | 201603_at | -0.7892 | 0.2296 | |
| GSE20347 | PPP1R12A | 4659 | 201603_at | -0.0512 | 0.8185 | |
| GSE23400 | PPP1R12A | 4659 | 201603_at | -0.3118 | 0.0581 | |
| GSE26886 | PPP1R12A | 4659 | 201603_at | 0.3509 | 0.1091 | |
| GSE29001 | PPP1R12A | 4659 | 201603_at | 0.2707 | 0.3213 | |
| GSE38129 | PPP1R12A | 4659 | 201603_at | -0.4096 | 0.0723 | |
| GSE45670 | PPP1R12A | 4659 | 201603_at | -0.8498 | 0.0000 | |
| GSE53622 | PPP1R12A | 4659 | 49170 | -0.6930 | 0.0000 | |
| GSE53624 | PPP1R12A | 4659 | 49170 | -0.4356 | 0.0000 | |
| GSE63941 | PPP1R12A | 4659 | 201603_at | -0.8950 | 0.0396 | |
| GSE77861 | PPP1R12A | 4659 | 201603_at | 0.4504 | 0.0592 | |
| GSE97050 | PPP1R12A | 4659 | A_23_P204564 | -1.3647 | 0.0782 | |
| SRP007169 | PPP1R12A | 4659 | RNAseq | 1.1887 | 0.0008 | |
| SRP008496 | PPP1R12A | 4659 | RNAseq | 1.5786 | 0.0000 | |
| SRP064894 | PPP1R12A | 4659 | RNAseq | -0.2445 | 0.3320 | |
| SRP133303 | PPP1R12A | 4659 | RNAseq | -0.0517 | 0.8637 | |
| SRP159526 | PPP1R12A | 4659 | RNAseq | -0.6618 | 0.0024 | |
| SRP193095 | PPP1R12A | 4659 | RNAseq | 0.0734 | 0.3636 | |
| SRP219564 | PPP1R12A | 4659 | RNAseq | -0.5202 | 0.4641 | |
| TCGA | PPP1R12A | 4659 | RNAseq | -0.1177 | 0.0237 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by PPP1R12A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPP1R12A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPP1R12A | 4659 | 4 | 3 | 23 | |
| GSE20123 | PPP1R12A | 4659 | 4 | 3 | 23 | |
| GSE43470 | PPP1R12A | 4659 | 3 | 1 | 39 | |
| GSE46452 | PPP1R12A | 4659 | 9 | 1 | 49 | |
| GSE47630 | PPP1R12A | 4659 | 10 | 1 | 29 | |
| GSE54993 | PPP1R12A | 4659 | 0 | 5 | 65 | |
| GSE54994 | PPP1R12A | 4659 | 7 | 1 | 45 | |
| GSE60625 | PPP1R12A | 4659 | 0 | 0 | 11 | |
| GSE74703 | PPP1R12A | 4659 | 3 | 1 | 32 | |
| GSE74704 | PPP1R12A | 4659 | 2 | 2 | 16 | |
| TCGA | PPP1R12A | 4659 | 15 | 13 | 68 |
Total number of gains: 57; Total number of losses: 31; Total Number of normals: 400.
Somatic mutations of PPP1R12A:
Generating mutation plots.
Highly correlated genes for PPP1R12A:
Showing top 20/1050 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPP1R12A | RBPMS2 | 0.804808 | 5 | 0 | 5 |
| PPP1R12A | MYOM1 | 0.800628 | 7 | 0 | 7 |
| PPP1R12A | SLMAP | 0.797943 | 7 | 0 | 7 |
| PPP1R12A | PPP1R12B | 0.788259 | 8 | 0 | 8 |
| PPP1R12A | HSPB7 | 0.78727 | 8 | 0 | 8 |
| PPP1R12A | NCAM1 | 0.78634 | 7 | 0 | 7 |
| PPP1R12A | MRVI1 | 0.78503 | 6 | 0 | 6 |
| PPP1R12A | RAB9B | 0.777536 | 5 | 0 | 5 |
| PPP1R12A | FAM124A | 0.777534 | 3 | 0 | 3 |
| PPP1R12A | SORCS1 | 0.777 | 4 | 0 | 4 |
| PPP1R12A | DAAM2 | 0.774771 | 7 | 0 | 6 |
| PPP1R12A | PGR | 0.771522 | 5 | 0 | 5 |
| PPP1R12A | MAMDC2 | 0.768895 | 5 | 0 | 5 |
| PPP1R12A | NEXN | 0.767607 | 6 | 0 | 6 |
| PPP1R12A | NEGR1 | 0.764944 | 6 | 0 | 6 |
| PPP1R12A | PPP1R14A | 0.762379 | 5 | 0 | 5 |
| PPP1R12A | KCNMA1 | 0.761165 | 9 | 0 | 9 |
| PPP1R12A | CSRP1 | 0.76028 | 8 | 0 | 8 |
| PPP1R12A | BCHE | 0.758972 | 8 | 0 | 8 |
| PPP1R12A | CHRDL1 | 0.756316 | 7 | 0 | 7 |
For details and further investigation, click here
