| Full name: heart and neural crest derivatives expressed 2 | Alias Symbol: dHand|Thing2|Hed|bHLHa26 | ||
| Type: protein-coding gene | Cytoband: 4q34.1 | ||
| Entrez ID: 9464 | HGNC ID: HGNC:4808 | Ensembl Gene: ENSG00000164107 | OMIM ID: 602407 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of HAND2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HAND2 | 9464 | 220480_at | -0.1919 | 0.7134 | |
| GSE20347 | HAND2 | 9464 | 220480_at | -0.0288 | 0.7136 | |
| GSE23400 | HAND2 | 9464 | 220480_at | -0.1401 | 0.0000 | |
| GSE26886 | HAND2 | 9464 | 220480_at | 0.3934 | 0.0223 | |
| GSE29001 | HAND2 | 9464 | 220480_at | 0.0358 | 0.8525 | |
| GSE38129 | HAND2 | 9464 | 220480_at | -0.1795 | 0.0251 | |
| GSE45670 | HAND2 | 9464 | 220480_at | -0.0990 | 0.2874 | |
| GSE53622 | HAND2 | 9464 | 137234 | -0.0959 | 0.7957 | |
| GSE53624 | HAND2 | 9464 | 137234 | 0.3488 | 0.1160 | |
| GSE63941 | HAND2 | 9464 | 220480_at | -0.1289 | 0.5541 | |
| GSE77861 | HAND2 | 9464 | 220480_at | -0.0294 | 0.8474 | |
| GSE97050 | HAND2 | 9464 | A_23_P373521 | -0.9059 | 0.2204 | |
| SRP133303 | HAND2 | 9464 | RNAseq | -1.6645 | 0.0018 | |
| SRP159526 | HAND2 | 9464 | RNAseq | 2.4736 | 0.0194 | |
| SRP219564 | HAND2 | 9464 | RNAseq | -0.1407 | 0.9452 | |
| TCGA | HAND2 | 9464 | RNAseq | -0.6384 | 0.1708 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by HAND2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HAND2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HAND2 | 9464 | 2 | 10 | 18 | |
| GSE20123 | HAND2 | 9464 | 2 | 10 | 18 | |
| GSE43470 | HAND2 | 9464 | 0 | 13 | 30 | |
| GSE46452 | HAND2 | 9464 | 1 | 36 | 22 | |
| GSE47630 | HAND2 | 9464 | 0 | 22 | 18 | |
| GSE54993 | HAND2 | 9464 | 10 | 0 | 60 | |
| GSE54994 | HAND2 | 9464 | 2 | 12 | 39 | |
| GSE60625 | HAND2 | 9464 | 0 | 0 | 11 | |
| GSE74703 | HAND2 | 9464 | 0 | 11 | 25 | |
| GSE74704 | HAND2 | 9464 | 1 | 5 | 14 | |
| TCGA | HAND2 | 9464 | 10 | 36 | 50 |
Total number of gains: 28; Total number of losses: 155; Total Number of normals: 305.
Somatic mutations of HAND2:
Generating mutation plots.
Highly correlated genes for HAND2:
Showing top 20/670 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HAND2 | C9orf47 | 0.769092 | 3 | 0 | 3 |
| HAND2 | EPHA7 | 0.755396 | 5 | 0 | 5 |
| HAND2 | MPDZ | 0.725444 | 4 | 0 | 4 |
| HAND2 | ANTXR2 | 0.725076 | 4 | 0 | 4 |
| HAND2 | FBXO30 | 0.717076 | 3 | 0 | 3 |
| HAND2 | IQUB | 0.71662 | 4 | 0 | 3 |
| HAND2 | RAB23 | 0.712645 | 3 | 0 | 3 |
| HAND2 | HAND2-AS1 | 0.711635 | 4 | 0 | 3 |
| HAND2 | ANKS1A | 0.710692 | 3 | 0 | 3 |
| HAND2 | PPP3CB | 0.703417 | 3 | 0 | 3 |
| HAND2 | USP12 | 0.700654 | 4 | 0 | 4 |
| HAND2 | RAMP1 | 0.698909 | 4 | 0 | 4 |
| HAND2 | ATN1 | 0.698074 | 3 | 0 | 3 |
| HAND2 | KCND3 | 0.69193 | 5 | 0 | 4 |
| HAND2 | DPYSL3 | 0.691481 | 4 | 0 | 3 |
| HAND2 | AEN | 0.689378 | 3 | 0 | 3 |
| HAND2 | IER2 | 0.688197 | 3 | 0 | 3 |
| HAND2 | SMYD1 | 0.687293 | 4 | 0 | 3 |
| HAND2 | ADARB1 | 0.684124 | 6 | 0 | 6 |
| HAND2 | PPARGC1A | 0.683686 | 3 | 0 | 3 |
For details and further investigation, click here
