| Full name: EPH receptor B3 | Alias Symbol: Hek2|Tyro6 | ||
| Type: protein-coding gene | Cytoband: 3q27.1 | ||
| Entrez ID: 2049 | HGNC ID: HGNC:3394 | Ensembl Gene: ENSG00000182580 | OMIM ID: 601839 |
| Drug and gene relationship at DGIdb | |||
EPHB3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04360 | Axon guidance |
Expression of EPHB3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EPHB3 | 2049 | 204600_at | -0.1176 | 0.8396 | |
| GSE20347 | EPHB3 | 2049 | 204600_at | -0.0292 | 0.8955 | |
| GSE23400 | EPHB3 | 2049 | 1438_at | -0.2963 | 0.0009 | |
| GSE26886 | EPHB3 | 2049 | 204600_at | -0.5804 | 0.0027 | |
| GSE29001 | EPHB3 | 2049 | 204600_at | -0.1099 | 0.7775 | |
| GSE38129 | EPHB3 | 2049 | 204600_at | 0.0591 | 0.7979 | |
| GSE45670 | EPHB3 | 2049 | 204600_at | 0.4741 | 0.0022 | |
| GSE53622 | EPHB3 | 2049 | 77780 | -0.3112 | 0.0166 | |
| GSE53624 | EPHB3 | 2049 | 77780 | -0.4264 | 0.0001 | |
| GSE63941 | EPHB3 | 2049 | 204600_at | 0.5153 | 0.3381 | |
| GSE77861 | EPHB3 | 2049 | 204600_at | 0.0955 | 0.6626 | |
| GSE97050 | EPHB3 | 2049 | A_23_P95060 | -0.0556 | 0.7930 | |
| SRP007169 | EPHB3 | 2049 | RNAseq | -0.9254 | 0.1976 | |
| SRP008496 | EPHB3 | 2049 | RNAseq | -0.9179 | 0.0334 | |
| SRP064894 | EPHB3 | 2049 | RNAseq | -0.5750 | 0.0463 | |
| SRP133303 | EPHB3 | 2049 | RNAseq | -0.0888 | 0.7502 | |
| SRP159526 | EPHB3 | 2049 | RNAseq | 1.3882 | 0.0625 | |
| SRP193095 | EPHB3 | 2049 | RNAseq | 0.1122 | 0.5549 | |
| SRP219564 | EPHB3 | 2049 | RNAseq | -0.9477 | 0.2637 | |
| TCGA | EPHB3 | 2049 | RNAseq | 0.0897 | 0.4413 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by EPHB3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EPHB3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EPHB3 | 2049 | 25 | 0 | 5 | |
| GSE20123 | EPHB3 | 2049 | 25 | 0 | 5 | |
| GSE43470 | EPHB3 | 2049 | 24 | 0 | 19 | |
| GSE46452 | EPHB3 | 2049 | 19 | 1 | 39 | |
| GSE47630 | EPHB3 | 2049 | 27 | 2 | 11 | |
| GSE54993 | EPHB3 | 2049 | 1 | 19 | 50 | |
| GSE54994 | EPHB3 | 2049 | 41 | 0 | 12 | |
| GSE60625 | EPHB3 | 2049 | 0 | 6 | 5 | |
| GSE74703 | EPHB3 | 2049 | 20 | 0 | 16 | |
| GSE74704 | EPHB3 | 2049 | 17 | 0 | 3 | |
| TCGA | EPHB3 | 2049 | 77 | 0 | 19 |
Total number of gains: 276; Total number of losses: 28; Total Number of normals: 184.
Somatic mutations of EPHB3:
Generating mutation plots.
Highly correlated genes for EPHB3:
Showing top 20/200 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EPHB3 | MAST4 | 0.642739 | 4 | 0 | 4 |
| EPHB3 | ANKRD22 | 0.632535 | 3 | 0 | 3 |
| EPHB3 | SULT2B1 | 0.630998 | 5 | 0 | 4 |
| EPHB3 | RHOV | 0.628396 | 4 | 0 | 3 |
| EPHB3 | RNASE7 | 0.622618 | 3 | 0 | 3 |
| EPHB3 | CLTB | 0.621484 | 3 | 0 | 3 |
| EPHB3 | CLIC3 | 0.6163 | 4 | 0 | 4 |
| EPHB3 | STX19 | 0.613821 | 4 | 0 | 3 |
| EPHB3 | C1orf210 | 0.612406 | 5 | 0 | 5 |
| EPHB3 | ARRDC3-AS1 | 0.608888 | 3 | 0 | 3 |
| EPHB3 | ZDHHC12 | 0.607843 | 3 | 0 | 3 |
| EPHB3 | PORCN | 0.605108 | 4 | 0 | 3 |
| EPHB3 | DTX2 | 0.604784 | 4 | 0 | 3 |
| EPHB3 | LPIN1 | 0.598287 | 4 | 0 | 3 |
| EPHB3 | RARG | 0.597654 | 7 | 0 | 5 |
| EPHB3 | TMEM154 | 0.59727 | 4 | 0 | 3 |
| EPHB3 | TRIP10 | 0.596114 | 3 | 0 | 3 |
| EPHB3 | CES2 | 0.595054 | 4 | 0 | 4 |
| EPHB3 | IL18 | 0.590357 | 4 | 0 | 4 |
| EPHB3 | IL36A | 0.588561 | 4 | 0 | 3 |
For details and further investigation, click here
