| Full name: 3-hydroxy-3-methylglutaryl-CoA synthase 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1p12 | ||
| Entrez ID: 3158 | HGNC ID: HGNC:5008 | Ensembl Gene: ENSG00000134240 | OMIM ID: 600234 |
| Drug and gene relationship at DGIdb | |||
HMGCS2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa03320 | PPAR signaling pathway |
Expression of HMGCS2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HMGCS2 | 3158 | 204607_at | -1.0008 | 0.6758 | |
| GSE20347 | HMGCS2 | 3158 | 204607_at | -0.5808 | 0.0030 | |
| GSE23400 | HMGCS2 | 3158 | 204607_at | -0.2847 | 0.0000 | |
| GSE26886 | HMGCS2 | 3158 | 204607_at | -0.4314 | 0.1586 | |
| GSE29001 | HMGCS2 | 3158 | 204607_at | -0.3453 | 0.1224 | |
| GSE38129 | HMGCS2 | 3158 | 204607_at | -0.6748 | 0.0013 | |
| GSE45670 | HMGCS2 | 3158 | 204607_at | -1.4263 | 0.0001 | |
| GSE53622 | HMGCS2 | 3158 | 101295 | -2.2849 | 0.0000 | |
| GSE53624 | HMGCS2 | 3158 | 101295 | -2.7653 | 0.0000 | |
| GSE63941 | HMGCS2 | 3158 | 204607_at | 0.1827 | 0.5644 | |
| GSE77861 | HMGCS2 | 3158 | 204607_at | -0.2355 | 0.1019 | |
| GSE97050 | HMGCS2 | 3158 | A_23_P103588 | -0.6721 | 0.1498 | |
| SRP064894 | HMGCS2 | 3158 | RNAseq | -7.1666 | 0.0000 | |
| SRP133303 | HMGCS2 | 3158 | RNAseq | -3.2886 | 0.0120 | |
| SRP159526 | HMGCS2 | 3158 | RNAseq | -5.3798 | 0.0063 | |
| SRP193095 | HMGCS2 | 3158 | RNAseq | -1.0061 | 0.2634 | |
| TCGA | HMGCS2 | 3158 | RNAseq | -3.8259 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 7.
Survival by HMGCS2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HMGCS2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HMGCS2 | 3158 | 3 | 5 | 22 | |
| GSE20123 | HMGCS2 | 3158 | 4 | 5 | 21 | |
| GSE43470 | HMGCS2 | 3158 | 1 | 3 | 39 | |
| GSE46452 | HMGCS2 | 3158 | 2 | 1 | 56 | |
| GSE47630 | HMGCS2 | 3158 | 11 | 3 | 26 | |
| GSE54993 | HMGCS2 | 3158 | 0 | 2 | 68 | |
| GSE54994 | HMGCS2 | 3158 | 12 | 1 | 40 | |
| GSE60625 | HMGCS2 | 3158 | 0 | 0 | 11 | |
| GSE74703 | HMGCS2 | 3158 | 1 | 3 | 32 | |
| GSE74704 | HMGCS2 | 3158 | 2 | 3 | 15 | |
| TCGA | HMGCS2 | 3158 | 18 | 23 | 55 |
Total number of gains: 54; Total number of losses: 49; Total Number of normals: 385.
Somatic mutations of HMGCS2:
Generating mutation plots.
Highly correlated genes for HMGCS2:
Showing top 20/523 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HMGCS2 | LRRC26 | 0.662734 | 3 | 0 | 3 |
| HMGCS2 | BPIFB1 | 0.660517 | 5 | 0 | 5 |
| HMGCS2 | SUFU | 0.647586 | 3 | 0 | 3 |
| HMGCS2 | RABEP2 | 0.645993 | 4 | 0 | 4 |
| HMGCS2 | CYP11B2 | 0.645504 | 3 | 0 | 3 |
| HMGCS2 | MAP1A | 0.6411 | 3 | 0 | 3 |
| HMGCS2 | CHST9 | 0.639917 | 5 | 0 | 4 |
| HMGCS2 | DNAI2 | 0.639609 | 3 | 0 | 3 |
| HMGCS2 | TRIM15 | 0.635769 | 4 | 0 | 3 |
| HMGCS2 | ZBTB47 | 0.634629 | 3 | 0 | 3 |
| HMGCS2 | PENK | 0.630401 | 3 | 0 | 3 |
| HMGCS2 | ST6GALNAC1 | 0.629837 | 6 | 0 | 6 |
| HMGCS2 | FGA | 0.625103 | 5 | 0 | 4 |
| HMGCS2 | SMIM6 | 0.623934 | 3 | 0 | 3 |
| HMGCS2 | SAMD5 | 0.623194 | 5 | 0 | 5 |
| HMGCS2 | BCAS1 | 0.622137 | 9 | 0 | 6 |
| HMGCS2 | MUC5AC | 0.621638 | 8 | 0 | 6 |
| HMGCS2 | PPM1L | 0.620921 | 5 | 0 | 5 |
| HMGCS2 | CGN | 0.617962 | 3 | 0 | 3 |
| HMGCS2 | DES | 0.616763 | 4 | 0 | 3 |
For details and further investigation, click here
