MS4A8

 

Full name: membrane spanning 4-domains A8 Alias Symbol: MS4A4|CD20L5
Type: protein-coding gene Cytoband: 11q12.2
Entrez ID: 83661 HGNC ID: HGNC:13380 Ensembl Gene: ENSG00000166959 OMIM ID: 606549
Drug and gene relationship at DGIdb

 

Expression of MS4A8:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MS4A8 83661 224355_s_at -0.1033 0.7656
GSE26886 MS4A8 83661 224355_s_at -0.0671 0.4653
GSE45670 MS4A8 83661 224355_s_at 0.0599 0.6547
GSE53622 MS4A8 83661 42405 -1.0966 0.0000
GSE53624 MS4A8 83661 42405 -1.7456 0.0000
GSE63941 MS4A8 83661 224355_s_at -0.0051 0.9763
GSE77861 MS4A8 83661 224355_s_at 0.0338 0.7497

Upregulated datasets: 0; Downregulated datasets: 2.  

 

Survival by MS4A8 expression:

 

GSE53622GSE53624

 

Note: Click image to view full size file.  

Copy number change of MS4A8:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MS4A8 83661 2 5 23
GSE20123 MS4A8 83661 2 5 23
GSE43470 MS4A8 83661 2 6 35
GSE46452 MS4A8 83661 8 4 47
GSE47630 MS4A8 83661 3 8 29
GSE54993 MS4A8 83661 3 0 67
GSE54994 MS4A8 83661 5 5 43
GSE60625 MS4A8 83661 0 3 8
GSE74703 MS4A8 83661 2 3 31
GSE74704 MS4A8 83661 2 3 15
TCGA MS4A8 83661 15 10 71

Total number of gains: 44; Total number of losses: 52; Total Number of normals: 392.  

 

Somatic mutations of MS4A8:

 

Generating mutation plots.

 

Highly correlated genes for MS4A8:

 

Showing top 20/21 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MS4A8CAPN90.765889303
MS4A8GP20.71788303
MS4A8CAPN80.698413303
MS4A8CHRM10.69661303
MS4A8TFF10.62213403
MS4A8TFF20.620664403
MS4A8ANG0.616706303
MS4A8ENPP60.61236403
MS4A8ERBB40.611757403
MS4A8PCAT180.604452403
MS4A8CMYA50.604195303
MS4A8TSPAN10.593879303
MS4A8NKX3-10.579902403
MS4A8ATP2A30.555194403
MS4A8ZG16B0.554914403
MS4A8CHAD0.552215503
MS4A8MLPH0.544756403
MS4A8AQP50.542756404
MS4A8NXPE40.531318603
MS4A8DMBT10.516041403

For details and further investigation, click here