| Full name: NK3 homeobox 1 | Alias Symbol: NKX3.1|BAPX2 | ||
| Type: protein-coding gene | Cytoband: 8p21.2 | ||
| Entrez ID: 4824 | HGNC ID: HGNC:7838 | Ensembl Gene: ENSG00000167034 | OMIM ID: 602041 |
| Drug and gene relationship at DGIdb | |||
NKX3-1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05200 | Pathways in cancer | |
| hsa05215 | Prostate cancer |
Expression of NKX3-1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NKX3-1 | 4824 | 209706_at | -1.3880 | 0.3685 | |
| GSE20347 | NKX3-1 | 4824 | 209706_at | 0.3826 | 0.1973 | |
| GSE23400 | NKX3-1 | 4824 | 209706_at | -0.6104 | 0.0000 | |
| GSE26886 | NKX3-1 | 4824 | 211498_s_at | 0.1907 | 0.1407 | |
| GSE29001 | NKX3-1 | 4824 | 209706_at | 0.7583 | 0.0786 | |
| GSE38129 | NKX3-1 | 4824 | 209706_at | 0.0545 | 0.8336 | |
| GSE45670 | NKX3-1 | 4824 | 209706_at | -0.9065 | 0.1942 | |
| GSE53622 | NKX3-1 | 4824 | 71969 | -0.8574 | 0.0039 | |
| GSE53624 | NKX3-1 | 4824 | 71969 | -0.9265 | 0.0002 | |
| GSE63941 | NKX3-1 | 4824 | 209706_at | -0.0924 | 0.9276 | |
| GSE77861 | NKX3-1 | 4824 | 211498_s_at | 0.0766 | 0.6822 | |
| GSE97050 | NKX3-1 | 4824 | A_33_P3281785 | -0.4799 | 0.3524 | |
| SRP064894 | NKX3-1 | 4824 | RNAseq | -3.1269 | 0.0000 | |
| SRP133303 | NKX3-1 | 4824 | RNAseq | -3.0343 | 0.0000 | |
| SRP159526 | NKX3-1 | 4824 | RNAseq | 0.2997 | 0.7426 | |
| SRP219564 | NKX3-1 | 4824 | RNAseq | 0.1938 | 0.7411 | |
| TCGA | NKX3-1 | 4824 | RNAseq | 0.4967 | 0.0027 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by NKX3-1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NKX3-1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NKX3-1 | 4824 | 4 | 12 | 14 | |
| GSE20123 | NKX3-1 | 4824 | 4 | 12 | 14 | |
| GSE43470 | NKX3-1 | 4824 | 4 | 8 | 31 | |
| GSE46452 | NKX3-1 | 4824 | 13 | 13 | 33 | |
| GSE47630 | NKX3-1 | 4824 | 10 | 8 | 22 | |
| GSE54993 | NKX3-1 | 4824 | 2 | 14 | 54 | |
| GSE54994 | NKX3-1 | 4824 | 8 | 18 | 27 | |
| GSE60625 | NKX3-1 | 4824 | 3 | 0 | 8 | |
| GSE74703 | NKX3-1 | 4824 | 4 | 7 | 25 | |
| GSE74704 | NKX3-1 | 4824 | 3 | 8 | 9 |
Total number of gains: 55; Total number of losses: 100; Total Number of normals: 237.
Somatic mutations of NKX3-1:
Generating mutation plots.
Highly correlated genes for NKX3-1:
Showing top 20/34 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NKX3-1 | SCGB2A1 | 0.775239 | 3 | 0 | 3 |
| NKX3-1 | CHRM1 | 0.733522 | 4 | 0 | 4 |
| NKX3-1 | TFF3 | 0.730982 | 7 | 0 | 6 |
| NKX3-1 | ZG16B | 0.723813 | 5 | 0 | 5 |
| NKX3-1 | BPIFB2 | 0.721429 | 6 | 0 | 5 |
| NKX3-1 | SCGB3A1 | 0.670636 | 5 | 0 | 4 |
| NKX3-1 | C6orf58 | 0.658142 | 7 | 0 | 6 |
| NKX3-1 | CAPN9 | 0.649139 | 5 | 0 | 4 |
| NKX3-1 | AGR2 | 0.635894 | 6 | 0 | 6 |
| NKX3-1 | PIP | 0.625789 | 6 | 0 | 5 |
| NKX3-1 | KIAA1324 | 0.620322 | 6 | 0 | 5 |
| NKX3-1 | GATA2 | 0.61924 | 3 | 0 | 3 |
| NKX3-1 | GP2 | 0.618868 | 6 | 0 | 5 |
| NKX3-1 | ERBB4 | 0.608775 | 3 | 0 | 3 |
| NKX3-1 | LGALS9 | 0.607551 | 3 | 0 | 3 |
| NKX3-1 | AQP5 | 0.606871 | 5 | 0 | 4 |
| NKX3-1 | CHST4 | 0.604683 | 6 | 0 | 4 |
| NKX3-1 | GLYATL2 | 0.604668 | 5 | 0 | 4 |
| NKX3-1 | SLC44A4 | 0.602749 | 6 | 0 | 5 |
| NKX3-1 | PAM16 | 0.599697 | 3 | 0 | 3 |
For details and further investigation, click here
