| Full name: N-acetylneuraminate synthase | Alias Symbol: SAS | ||
| Type: protein-coding gene | Cytoband: 9q22.33 | ||
| Entrez ID: 54187 | HGNC ID: HGNC:19237 | Ensembl Gene: ENSG00000095380 | OMIM ID: 605202 |
| Drug and gene relationship at DGIdb | |||
Expression of NANS:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NANS | 54187 | 218189_s_at | -0.1079 | 0.8423 | |
| GSE20347 | NANS | 54187 | 218189_s_at | -0.1688 | 0.2957 | |
| GSE23400 | NANS | 54187 | 218189_s_at | -0.0180 | 0.8441 | |
| GSE26886 | NANS | 54187 | 218189_s_at | -0.0564 | 0.7853 | |
| GSE29001 | NANS | 54187 | 218189_s_at | -0.1931 | 0.5118 | |
| GSE38129 | NANS | 54187 | 218189_s_at | 0.0352 | 0.8173 | |
| GSE45670 | NANS | 54187 | 218189_s_at | -0.0335 | 0.8635 | |
| GSE53622 | NANS | 54187 | 129200 | -0.2954 | 0.0005 | |
| GSE53624 | NANS | 54187 | 129200 | -0.0294 | 0.6746 | |
| GSE63941 | NANS | 54187 | 218189_s_at | 0.3405 | 0.5146 | |
| GSE77861 | NANS | 54187 | 218189_s_at | -0.4712 | 0.0170 | |
| GSE97050 | NANS | 54187 | A_33_P3291776 | 0.3995 | 0.3157 | |
| SRP007169 | NANS | 54187 | RNAseq | -1.0497 | 0.0430 | |
| SRP008496 | NANS | 54187 | RNAseq | -0.8650 | 0.0154 | |
| SRP064894 | NANS | 54187 | RNAseq | -0.1012 | 0.7406 | |
| SRP133303 | NANS | 54187 | RNAseq | -0.0476 | 0.8048 | |
| SRP159526 | NANS | 54187 | RNAseq | -0.5385 | 0.0087 | |
| SRP193095 | NANS | 54187 | RNAseq | -0.4872 | 0.0084 | |
| SRP219564 | NANS | 54187 | RNAseq | -0.0806 | 0.8001 | |
| TCGA | NANS | 54187 | RNAseq | -0.1621 | 0.0058 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by NANS expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NANS:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NANS | 54187 | 7 | 8 | 15 | |
| GSE20123 | NANS | 54187 | 7 | 7 | 16 | |
| GSE43470 | NANS | 54187 | 6 | 3 | 34 | |
| GSE46452 | NANS | 54187 | 6 | 14 | 39 | |
| GSE47630 | NANS | 54187 | 1 | 17 | 22 | |
| GSE54993 | NANS | 54187 | 3 | 3 | 64 | |
| GSE54994 | NANS | 54187 | 8 | 11 | 34 | |
| GSE60625 | NANS | 54187 | 0 | 0 | 11 | |
| GSE74703 | NANS | 54187 | 5 | 3 | 28 | |
| GSE74704 | NANS | 54187 | 3 | 5 | 12 | |
| TCGA | NANS | 54187 | 27 | 22 | 47 |
Total number of gains: 73; Total number of losses: 93; Total Number of normals: 322.
Somatic mutations of NANS:
Generating mutation plots.
Highly correlated genes for NANS:
Showing top 20/362 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NANS | PPP4R2 | 0.79489 | 3 | 0 | 3 |
| NANS | CHCHD1 | 0.784756 | 4 | 0 | 4 |
| NANS | ERCC6 | 0.783511 | 3 | 0 | 3 |
| NANS | LAMTOR3 | 0.778487 | 3 | 0 | 3 |
| NANS | TMEM234 | 0.769498 | 3 | 0 | 3 |
| NANS | VPS26A | 0.762634 | 3 | 0 | 3 |
| NANS | NPAS2 | 0.761698 | 3 | 0 | 3 |
| NANS | HELQ | 0.760158 | 3 | 0 | 3 |
| NANS | PRPF38A | 0.757169 | 3 | 0 | 3 |
| NANS | TYSND1 | 0.753795 | 3 | 0 | 3 |
| NANS | COMMD8 | 0.751203 | 3 | 0 | 3 |
| NANS | ZNF613 | 0.747703 | 3 | 0 | 3 |
| NANS | ZNHIT6 | 0.74241 | 3 | 0 | 3 |
| NANS | BTRC | 0.738834 | 3 | 0 | 3 |
| NANS | SPIN4 | 0.73769 | 3 | 0 | 3 |
| NANS | EPS15 | 0.730577 | 4 | 0 | 3 |
| NANS | KLHDC10 | 0.724823 | 3 | 0 | 3 |
| NANS | PDZD8 | 0.721172 | 3 | 0 | 3 |
| NANS | ZACN | 0.718976 | 3 | 0 | 3 |
| NANS | OSBPL8 | 0.71773 | 3 | 0 | 3 |
For details and further investigation, click here
