ESR1

 

Full name: estrogen receptor 1 Alias Symbol: NR3A1|Era|ER-alpha
Type: protein-coding gene Cytoband: 6q25.1-q25.2
Entrez ID: 2099 HGNC ID: HGNC:3467 Ensembl Gene: ENSG00000091831 OMIM ID: 133430
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 6/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

ESR1 involved pathways:

KEGG pathway Description View
hsa04915Estrogen signaling pathway
hsa04917Prolactin signaling pathway
hsa04919Thyroid hormone signaling pathway
hsa04961Endocrine and other factor-regulated calcium reabsorption
hsa05205Proteoglycans in cancer

 

Expression of ESR1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ESR1 2099 205225_at 1.4285 0.1056
GSE20347 ESR1 2099 211234_x_at -0.0074 0.9412
GSE23400 ESR1 2099 211233_x_at -0.0396 0.3813
GSE26886 ESR1 2099 211234_x_at -0.0393 0.8245
GSE29001 ESR1 2099 205225_at -0.2634 0.6499
GSE38129 ESR1 2099 211234_x_at -0.1030 0.2342
GSE45670 ESR1 2099 211234_x_at -0.0457 0.5430
GSE53622 ESR1 2099 39250 0.1711 0.0508
GSE53624 ESR1 2099 39250 0.0302 0.6966
GSE63941 ESR1 2099 211235_s_at 0.3152 0.0238
GSE77861 ESR1 2099 211234_x_at -0.0574 0.5386
GSE97050 ESR1 2099 A_24_P383478 -0.0683 0.8269
SRP064894 ESR1 2099 RNAseq -0.3584 0.3392
SRP133303 ESR1 2099 RNAseq 0.0128 0.9696
SRP159526 ESR1 2099 RNAseq -0.8255 0.2145
SRP193095 ESR1 2099 RNAseq 0.3588 0.1415
SRP219564 ESR1 2099 RNAseq 0.1073 0.7565
TCGA ESR1 2099 RNAseq -0.2268 0.4038

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by ESR1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ESR1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ESR1 2099 1 4 25
GSE20123 ESR1 2099 1 3 26
GSE43470 ESR1 2099 4 0 39
GSE46452 ESR1 2099 3 10 46
GSE47630 ESR1 2099 9 4 27
GSE54993 ESR1 2099 3 2 65
GSE54994 ESR1 2099 8 8 37
GSE60625 ESR1 2099 0 1 10
GSE74703 ESR1 2099 4 0 32
GSE74704 ESR1 2099 0 1 19
TCGA ESR1 2099 11 21 64

Total number of gains: 44; Total number of losses: 54; Total Number of normals: 390.  

 

Somatic mutations of ESR1:

 

Generating mutation plots.

 

Highly correlated genes for ESR1:

 

Showing top 20/587 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ESR1DCDC10.785319303
ESR1BBC30.765119303
ESR1YY20.763912303
ESR1NKX6-30.756507303
ESR1KRTAP10-120.736982303
ESR1ABTB10.725456404
ESR1FAM131A0.724017303
ESR1STRC0.722678303
ESR1CGA0.721275303
ESR1SHISA80.719988403
ESR1PRSS380.718141303
ESR1TPH20.7163404
ESR1SERTM10.716252303
ESR1C1QL20.715512303
ESR1OR2T10.714813303
ESR1PLA2G2C0.712038303
ESR1OR2T270.711988303
ESR1KRTAP4-80.707672404
ESR1TCP100.707288303
ESR1PAX60.703119504

For details and further investigation, click here