| Full name: proteasome subunit beta 8 | Alias Symbol: RING10|D6S216E|PSMB5i|beta5i | ||
| Type: protein-coding gene | Cytoband: 6p21.32 | ||
| Entrez ID: 5696 | HGNC ID: HGNC:9545 | Ensembl Gene: ENSG00000204264 | OMIM ID: 177046 |
| Drug and gene relationship at DGIdb | |||
Expression of PSMB8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PSMB8 | 5696 | 209040_s_at | 0.7928 | 0.1374 | |
| GSE20347 | PSMB8 | 5696 | 209040_s_at | 0.3081 | 0.2864 | |
| GSE23400 | PSMB8 | 5696 | 209040_s_at | 0.7355 | 0.0000 | |
| GSE26886 | PSMB8 | 5696 | 209040_s_at | 0.0465 | 0.9233 | |
| GSE29001 | PSMB8 | 5696 | 209040_s_at | 0.6903 | 0.0926 | |
| GSE38129 | PSMB8 | 5696 | 209040_s_at | 0.5520 | 0.0143 | |
| GSE45670 | PSMB8 | 5696 | 209040_s_at | 0.7750 | 0.0137 | |
| GSE53622 | PSMB8 | 5696 | 31271 | 0.6271 | 0.0000 | |
| GSE53624 | PSMB8 | 5696 | 31271 | 0.5864 | 0.0000 | |
| GSE63941 | PSMB8 | 5696 | 209040_s_at | -0.3568 | 0.8518 | |
| GSE77861 | PSMB8 | 5696 | 209040_s_at | -0.0452 | 0.9227 | |
| GSE97050 | PSMB8 | 5696 | A_23_P250629 | 1.0571 | 0.0903 | |
| SRP007169 | PSMB8 | 5696 | RNAseq | 0.8935 | 0.0664 | |
| SRP008496 | PSMB8 | 5696 | RNAseq | 0.4659 | 0.2526 | |
| SRP064894 | PSMB8 | 5696 | RNAseq | 0.8158 | 0.0007 | |
| SRP133303 | PSMB8 | 5696 | RNAseq | 0.5343 | 0.0070 | |
| SRP159526 | PSMB8 | 5696 | RNAseq | 0.0647 | 0.8895 | |
| SRP193095 | PSMB8 | 5696 | RNAseq | 0.1320 | 0.4963 | |
| SRP219564 | PSMB8 | 5696 | RNAseq | 0.9797 | 0.0107 | |
| TCGA | PSMB8 | 5696 | RNAseq | 0.2640 | 0.0010 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PSMB8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PSMB8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PSMB8 | 5696 | 5 | 0 | 25 | |
| GSE20123 | PSMB8 | 5696 | 5 | 0 | 25 | |
| GSE43470 | PSMB8 | 5696 | 5 | 1 | 37 | |
| GSE46452 | PSMB8 | 5696 | 2 | 10 | 47 | |
| GSE47630 | PSMB8 | 5696 | 8 | 4 | 28 | |
| GSE54993 | PSMB8 | 5696 | 3 | 1 | 66 | |
| GSE54994 | PSMB8 | 5696 | 11 | 4 | 38 | |
| GSE60625 | PSMB8 | 5696 | 1 | 0 | 10 | |
| GSE74703 | PSMB8 | 5696 | 5 | 0 | 31 | |
| GSE74704 | PSMB8 | 5696 | 2 | 0 | 18 | |
| TCGA | PSMB8 | 5696 | 16 | 16 | 64 |
Total number of gains: 63; Total number of losses: 36; Total Number of normals: 389.
Somatic mutations of PSMB8:
Generating mutation plots.
Highly correlated genes for PSMB8:
Showing top 20/957 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PSMB8 | PSMB9 | 0.82783 | 12 | 0 | 12 |
| PSMB8 | TAP1 | 0.789398 | 10 | 0 | 10 |
| PSMB8 | HLA-F | 0.772904 | 12 | 0 | 12 |
| PSMB8 | BTN3A2 | 0.743709 | 12 | 0 | 12 |
| PSMB8 | KTI12 | 0.742624 | 3 | 0 | 3 |
| PSMB8 | AZIN1 | 0.737307 | 3 | 0 | 3 |
| PSMB8 | BTN3A3 | 0.733697 | 10 | 0 | 10 |
| PSMB8 | UBE2L6 | 0.733571 | 12 | 0 | 10 |
| PSMB8 | CCDC15 | 0.725015 | 3 | 0 | 3 |
| PSMB8 | RNF213 | 0.723773 | 5 | 0 | 4 |
| PSMB8 | C8orf82 | 0.722408 | 3 | 0 | 3 |
| PSMB8 | NMI | 0.718706 | 13 | 0 | 10 |
| PSMB8 | PSMB10 | 0.717961 | 13 | 0 | 11 |
| PSMB8 | CMPK2 | 0.713633 | 6 | 0 | 6 |
| PSMB8 | FBXO6 | 0.712166 | 7 | 0 | 6 |
| PSMB8 | HLA-B | 0.711874 | 13 | 0 | 12 |
| PSMB8 | PARP14 | 0.707563 | 8 | 0 | 7 |
| PSMB8 | PARP9 | 0.704656 | 9 | 0 | 8 |
| PSMB8 | COMMD7 | 0.702882 | 3 | 0 | 3 |
| PSMB8 | HLA-A | 0.702177 | 13 | 0 | 12 |
For details and further investigation, click here
