EXOSC9

 

Full name: exosome component 9 Alias Symbol: PM/Scl-75|Rrp45p|RRP45|p5|p6
Type: protein-coding gene Cytoband: 4q27
Entrez ID: 5393 HGNC ID: HGNC:9137 Ensembl Gene: ENSG00000123737 OMIM ID: 606180
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of EXOSC9:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 EXOSC9 5393 205061_s_at 0.4037 0.0569
GSE20347 EXOSC9 5393 205061_s_at 0.2069 0.0210
GSE23400 EXOSC9 5393 205061_s_at 0.1967 0.0000
GSE26886 EXOSC9 5393 205061_s_at 0.3570 0.0488
GSE29001 EXOSC9 5393 205061_s_at 0.2939 0.2101
GSE38129 EXOSC9 5393 205061_s_at 0.3801 0.0360
GSE45670 EXOSC9 5393 205061_s_at 0.1401 0.2510
GSE53622 EXOSC9 5393 77123 0.3366 0.0000
GSE53624 EXOSC9 5393 77123 0.5129 0.0000
GSE63941 EXOSC9 5393 205061_s_at -0.1751 0.7149
GSE77861 EXOSC9 5393 205061_s_at 0.4441 0.0143
GSE97050 EXOSC9 5393 A_23_P81121 0.4172 0.2318
SRP007169 EXOSC9 5393 RNAseq 0.9867 0.0698
SRP064894 EXOSC9 5393 RNAseq 0.4765 0.0081
SRP133303 EXOSC9 5393 RNAseq 0.6427 0.0000
SRP159526 EXOSC9 5393 RNAseq 0.3556 0.1653
SRP193095 EXOSC9 5393 RNAseq 0.3651 0.0046
SRP219564 EXOSC9 5393 RNAseq 0.1852 0.4519
TCGA EXOSC9 5393 RNAseq 0.1885 0.0016

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by EXOSC9 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of EXOSC9:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 EXOSC9 5393 1 13 16
GSE20123 EXOSC9 5393 1 13 16
GSE43470 EXOSC9 5393 0 13 30
GSE46452 EXOSC9 5393 1 36 22
GSE47630 EXOSC9 5393 0 22 18
GSE54993 EXOSC9 5393 9 0 61
GSE54994 EXOSC9 5393 1 10 42
GSE60625 EXOSC9 5393 0 1 10
GSE74703 EXOSC9 5393 0 11 25
GSE74704 EXOSC9 5393 0 7 13
TCGA EXOSC9 5393 8 34 54

Total number of gains: 21; Total number of losses: 160; Total Number of normals: 307.  

 

Somatic mutations of EXOSC9:

 

Generating mutation plots.

 

Highly correlated genes for EXOSC9:

 

Showing top 20/943 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
EXOSC9RAPGEF40.669949404
EXOSC9PGM2L10.655827403
EXOSC9TMED60.654576303
EXOSC9MTRR0.65088504
EXOSC9ABCE10.64945911010
EXOSC9MS4A140.643099303
EXOSC9FBP10.642316303
EXOSC9CCDC180.64112606
EXOSC9ATF20.639785403
EXOSC9RPRD1B0.631696403
EXOSC9C4orf460.630457605
EXOSC9DCAF130.629622807
EXOSC9CYBB0.62825403
EXOSC9NUMBL0.626143303
EXOSC9CDKN30.6252361009
EXOSC9PFDN20.6216512010
EXOSC9DNAJB110.620136605
EXOSC9NEDD10.617766806
EXOSC9RARRES10.61714403
EXOSC9BZW20.613153604

For details and further investigation, click here