| Full name: cyclin dependent kinase inhibitor 3 | Alias Symbol: KAP|CDI1 | ||
| Type: protein-coding gene | Cytoband: 14q22.2 | ||
| Entrez ID: 1033 | HGNC ID: HGNC:1791 | Ensembl Gene: ENSG00000100526 | OMIM ID: 123832 |
| Drug and gene relationship at DGIdb | |||
Expression of CDKN3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CDKN3 | 1033 | 1555758_a_at | 2.0231 | 0.0054 | |
| GSE20347 | CDKN3 | 1033 | 209714_s_at | 1.9787 | 0.0000 | |
| GSE23400 | CDKN3 | 1033 | 209714_s_at | 1.4910 | 0.0000 | |
| GSE26886 | CDKN3 | 1033 | 209714_s_at | 1.3129 | 0.0023 | |
| GSE29001 | CDKN3 | 1033 | 209714_s_at | 1.9265 | 0.0001 | |
| GSE38129 | CDKN3 | 1033 | 209714_s_at | 2.1322 | 0.0000 | |
| GSE45670 | CDKN3 | 1033 | 1555758_a_at | 1.6976 | 0.0000 | |
| GSE53622 | CDKN3 | 1033 | 65195 | 2.0707 | 0.0000 | |
| GSE53624 | CDKN3 | 1033 | 65195 | 2.2930 | 0.0000 | |
| GSE63941 | CDKN3 | 1033 | 1555758_a_at | 3.3864 | 0.0002 | |
| GSE77861 | CDKN3 | 1033 | 209714_s_at | 1.1216 | 0.0838 | |
| GSE97050 | CDKN3 | 1033 | A_23_P48669 | 2.1512 | 0.0631 | |
| SRP007169 | CDKN3 | 1033 | RNAseq | 1.5925 | 0.0005 | |
| SRP008496 | CDKN3 | 1033 | RNAseq | 1.4427 | 0.0001 | |
| SRP064894 | CDKN3 | 1033 | RNAseq | 1.8655 | 0.0000 | |
| SRP133303 | CDKN3 | 1033 | RNAseq | 1.9353 | 0.0000 | |
| SRP159526 | CDKN3 | 1033 | RNAseq | 1.3572 | 0.0042 | |
| SRP193095 | CDKN3 | 1033 | RNAseq | 1.0477 | 0.0000 | |
| SRP219564 | CDKN3 | 1033 | RNAseq | 2.1693 | 0.0033 | |
| TCGA | CDKN3 | 1033 | RNAseq | 1.3464 | 0.0000 |
Upregulated datasets: 18; Downregulated datasets: 0.
Survival by CDKN3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CDKN3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CDKN3 | 1033 | 8 | 3 | 19 | |
| GSE20123 | CDKN3 | 1033 | 8 | 3 | 19 | |
| GSE43470 | CDKN3 | 1033 | 9 | 1 | 33 | |
| GSE46452 | CDKN3 | 1033 | 16 | 3 | 40 | |
| GSE47630 | CDKN3 | 1033 | 11 | 10 | 19 | |
| GSE54993 | CDKN3 | 1033 | 3 | 8 | 59 | |
| GSE54994 | CDKN3 | 1033 | 19 | 4 | 30 | |
| GSE60625 | CDKN3 | 1033 | 0 | 2 | 9 | |
| GSE74703 | CDKN3 | 1033 | 8 | 1 | 27 | |
| GSE74704 | CDKN3 | 1033 | 3 | 2 | 15 | |
| TCGA | CDKN3 | 1033 | 33 | 13 | 50 |
Total number of gains: 118; Total number of losses: 50; Total Number of normals: 320.
Somatic mutations of CDKN3:
Generating mutation plots.
Highly correlated genes for CDKN3:
Showing top 20/2025 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CDKN3 | DLGAP5 | 0.882248 | 13 | 0 | 13 |
| CDKN3 | UBE2C | 0.863959 | 13 | 0 | 13 |
| CDKN3 | TPX2 | 0.861238 | 13 | 0 | 13 |
| CDKN3 | WDHD1 | 0.860905 | 13 | 0 | 13 |
| CDKN3 | CENPF | 0.853583 | 12 | 0 | 12 |
| CDKN3 | KIF20A | 0.851604 | 13 | 0 | 13 |
| CDKN3 | BUB1 | 0.850359 | 11 | 0 | 11 |
| CDKN3 | CDC20 | 0.843827 | 12 | 0 | 11 |
| CDKN3 | CEP55 | 0.843425 | 13 | 0 | 13 |
| CDKN3 | KIF4A | 0.839039 | 12 | 0 | 12 |
| CDKN3 | GINS1 | 0.834781 | 12 | 0 | 12 |
| CDKN3 | AURKA | 0.833528 | 13 | 0 | 13 |
| CDKN3 | CKS1B | 0.833091 | 13 | 0 | 13 |
| CDKN3 | CDK1 | 0.833003 | 12 | 0 | 12 |
| CDKN3 | CENPN | 0.830427 | 13 | 0 | 13 |
| CDKN3 | STIL | 0.830103 | 12 | 0 | 12 |
| CDKN3 | VRK1 | 0.828923 | 13 | 0 | 13 |
| CDKN3 | KIF2C | 0.828116 | 13 | 0 | 12 |
| CDKN3 | TRIP13 | 0.828091 | 12 | 0 | 12 |
| CDKN3 | UBE2T | 0.826748 | 9 | 0 | 9 |
For details and further investigation, click here
